Evidence Based

L. crispatus Health Benefits

Written by Biljana Novkovic, PhD | Last updated:

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L. crispatus

L. crispatus is a great probiotic for female urogenital health.

What is Lactobacillus crispatus?

Lactobacilli inhabiting the human vagina are the first line of defense in the female urogenital and reproductive tracts. Lactobacillus crispatus is prevalent in the healthy cervicovaginal microbiota, where it produces lactic acid, a potent broad-spectrum bactericide, and virucide, and acts as an immunomodulatory agent [1].

Health Benefits of L. crispatus

1) Promotes Female Urogenital Health

L. crispatus maintains normal vaginal microbiota and protects the genitourinary tract against pathological conditions [2].

L. crispatus reduces recurrent urinary tract infections in premenopausal women [3].

L. crispatus inhibits Chlamydia trachomatis, the most common sexually transmitted bacterial pathogen, in human epithelial cells and macrophages [2, 4].

L. crispatus promotes defense against Candida albicans infection [5,6].

L. crispatus inhibits E. coli activity [7].

Cervicovaginal mucus with high L. crispatus concentrations can trap the HIV virus [8].

2) May Alleviate Allergies

Oral ingestion of L. crispatus alleviates allergic rhinitis in mice via the adjustment of the Th1/Th2 balance [9, 10, 11].

3) Has Differential Effects on the GI Tract

L. crispatus can ameliorate colitis in mice [12], however, a specific strain, M206119, exacerbates intestinal inflammation [13].

4) May Have Anti-Cancer Properties

L. crispatus inhibits proliferation of breast cancer cells [14], human cervical and colon adenocarcinoma cells [15].


  • Increases [16, 17] and decreases IL-6 [2].
  • Decreases IL-8 [2, 5, 16] and IL-4 [9].
  • Increases IL-10 [2,18] and IL-12p70 [18].
  • Decreases TNF-α [2].
  • Induces NF-κB activation [16].
  • Increases IgA [17] and decreases IgE [9].
  • Increases CD4(+) CD25(+) FOXP3(+) Treg cells [18].


L. crispatus was shown to be safe in women treated for bacterial vaginosis [19, 20]. Mild inflammation of the urinary tract was noted in some women [21].

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About the Author

Biljana Novkovic

Biljana Novkovic

Biljana received her PhD from Hokkaido University.
Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. She is passionate about releasing the most accurate science and health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. She believes that SelfHacked has the best science that is also layperson-friendly on the web.

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