Autoimmunity

Emerging Health Benefits of L. lactis

L. lactis is a commonly used probiotic whose health benefits we are just beginning to understand. This bacterium boosts the immune system, may combat allergies, hypertension, and IBD, and has beneficial effects on the skin.

Introduction

Lactococcus lactis is a lactic acid producing Gram-positive bacterium used extensively in the production of buttermilk, cheese, pickled vegetables and other fermented products.

L. lactis is often studied as a genetically modified organism for the treatment of animal (R,R,R,R,R,R) and human disease (R). Its health benefits as a probiotic, however, are less known and researched.

Note that this post is about Lactococcus lactis. For more information about Lactobacillus lactis check out the post about L. delbrueckii.

Health Benefits of L. lactis

1) L. lactis Boosts Immunity

Autoimmunity

Yogurt fermented with L. lactis activates plasmacytoid dendritic cells (pDC), that are important for both innate and adaptive immune responses (R,R), and lowers the risk of common cold in human subjects (R).

L. lactis activates natural killer (NK) cells and enhances their cytotoxic activity (R).

L. lactis improves resistance against pneumococcal infection by improving pathogen lung clearance, reduces lung injuries and increases survival of infected mice (R,R).

L. lactis-fed mice have drastically improved survival rate, reduced weight loss, and reduced lung damage when infected by murine parainfluenza virus (mPIV1) (R) the influenza  virus (H1N1) (R).

Kefir-isolated L. lactis protect cells from C. difficile toxins (R).

2) L. lactis May Alleviate Allergies

shutterstock_311618567

Both live and heat-killed L. lactis ameliorate the allergic response in mice (R,R,R).

L. lactis decreases the Th2 response (R) and induces a Th1-polarizing program in dendritic cells in mice (R).

L. lactis significantly attenuates atopic esophageal and bronchoalveolar eosinophilic inflammation in mice (R).

Ethanol can increase the allergic response. L. lactis was shown to restore oral tolerance in mice, by reducing local and systemic allergic outcomes such as IL-4 and IgE (R).

Oral treatment of newborn pigs with L. lactis significantly reduced the subsequent frequency of allergy, by dampening the Th-2 immune response (R).

3) L. lactis May be Beneficial in IBD

Soy milk fermented with L. lactis exhibits anti-inflammatory effects and prevents IBD in mice (R,R).

Administration of heat-killed L. lactis suppressed IBD symptoms, such as shortening of colon length, damage to the colon mucosa, and spleen enlargement in mice (R).

L. lactis reduced inflammatory cytokine production and nitric oxide expression in mice with colitis (R).

4) L. lactis is Beneficial for the Skin

shutterstock_297804983

L. lactis increased sebum content, thereby potentially reinforcing the skin barrier in healthy young women (R).

L. lactis strain maintained skin hydration, and improved subjective skin elasticity in middle-aged Japanese women (R).

5) L. lactis exhibits Antioxidant Properties

Exopolysaccharide (EPS) of L. lactis increased catalase , superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, and decreased malondialdehyde (MDA) levels in mice (R).

6) L. lactis May Lower Blood Pressure

L. lactis reduces blood pressure, LDL cholesterol and triglyceride contents in hypertensive rats (R).

Milk fermented by L. lactis exhibits systolic and diastolic blood pressure- and heart-rate-lowering effect in rats with hypertension (R).

7) L. lactis May be Beneficial in Aging

Long-term oral intake of L. lactis suppressed the reduction of bone density and body weight in senescence-accelerated mice (R).

L. lactis May Prevent Age-Related Hearing Loss

Intake of heat-killed L. lactis altered the intestinal flora, affected plasma metabolite levels, including fatty acid levels, and slowed down age-related hearing loss in mice, by inhibiting the loss of neurons and hair cells in mouse inner ear (R).

8) L. lactis May Combat Cancer

L. lactis inhibits the proliferation of lung cancer cells, colorectal cancer cells, gastric carcinoma cells and breast cancer cells (R).

Cytoplasmic fraction of L. lactis inhibits human stomach cancer cell proliferation and induces cancer cell death (R).

Technical

  • L. lactis decreases IL-4 in allergy (R,R,R) and increases IL-4 in infection (R).
  • L. lactis decreases IL-8 (R,R), IL-13 (R), and IL-18 (R).
  • L. lactis can both increase (R,R) and decrease IL-6 (R).
  • L. lactis increases IL-10 (R,R,R) and IL-12 (R).
  • L. lactis decreases IFN-γ (R) in inflammation and increases IFN-γ in allergy and infection (R,R,R).
  • L. lactis decreases  TNF-α in inflammation (R,R)  and increases TNF-α in infection and anti-tumor response (R,R,R).
  • L. lactis can increase CD4+ T Tregs bearing surface TGF-β (R).
  • L. lactis decreases NO (R) and iNOS (R) in inflammation (a study where iNOS was increased: R).
  • L. lactis decreases and MIP-2 (R).
  • L. lactis decreases IgE (R,R) and increases IgA, IgG (R), and IgG2 (R).
  • L. lactis decreases NOD-1, NOD-2, TLR-4 (R), CCL11 (eotaxin-1), CCL17 (TARC) (R) and COX-2 (R).
  • L. lactis inhibits the activity of angiotensin I-converting enzyme (ACE) (R).

Safety

L. lactis is mostly nonpathogenic in humans, however, a number of cases of infection with L. lactis have been reported over the years (R).

Some strains of L. lactis increase biogenic amines putrescine and tyramine (R).

Probiotics should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms, where they may cause infections.

Buy L. lactis

Product containing L. lactis:

Leave a Reply