Disclaimer: By writing this post, we are not recommending this drug. Some of our readers who were already taking the drug requested that we commission a post on it and we are simply providing information that is available in the scientific and clinical literature. Please discuss your medications with your doctor.
What is DMT?
DMT (N,N-Dimethyltryptamine) is a psychedelic compound belonging to the tryptamine family of molecules. It is structurally similar to serotonin and is considered one of the most intense psychedelic experiences.
DMT is found in numerous plants and animals, including humans. It is found in trace amounts in the mammalian brain, lungs, and spinal cord and is a byproduct of normal metabolism. DMT levels increase in the rodent brain during periods of extreme stress [1, 2, 3].
Pure DMT is ineffective when consumed orally. For DMT to be orally active, it must be co-administered with an MAO-A inhibitor. MAO-A is an enzyme found in the gut that is responsible for breaking down (through oxidation) different neurotransmitters (dopamine and serotonin) as well as DMT [4, 5].
Historically, South American tribes would prepare a brew called ayahuasca, which contains DMT and an MAO-A inhibitor. The combined effect of both compounds allows for DMT to be absorbed into the bloodstream before being broken down. This results in a longer and more intense high than smoking or intravenous delivery of DMT .
They consumed these drinks in spiritual and religious ceremonies. It induces euphoria and hallucinations that are believed to have mystical and healing powers .
DMT was first synthesized in 1931 by Canadian chemist Richard Manske, and was first isolated in 1946 from Mimosa hostilis, a plant that was used by indigenous Brazilians in a sacred beverage called jurema .
Internationally, the trade of DMT is monitored closely and its use is restricted to scientific research and medical use. In the US, it is classified as a Schedule I drug, meaning it has no medical use and has a high potential for abuse.
Although a number of different roles for DMT in the body have been hypothesized, it’s purpose is not fully understood. The earliest studies predicted that DMT played an important role in dreams and in death, but these have not been proven. Current research suggests DMT may act as a neurotransmitter involved in sense perception [9, 10, 2].
Mechanism of Action
- DMT binds to and activates the sigma-1 receptor (Sig-1R), which protects against inflammation and cell death .
- DMT binds to and activates receptors of the serotonin system (5-HT1A, 5-HT2A, and 5-HT2C) [12, 13, 14].
- Activation of serotonin receptors causes the release of glutamate, which activates glutamate receptors .
- Additionally, the psychedelic effects of DMT are attributed to the activation of the trace amine associated receptor (TAAR6) .
How DMT is Used
In the 1960s, DMT became known in the United States for its rapid onset and short duration, earning the name “the businessman’s trip” .
In recent years, recreational use of DMT has been increasing, with 31% of users reporting its psychotherapeutic benefits as the main reason for consumption .
Pure DMT is a white, crystalline substance that is most often vaporized at doses ranging from 20-70 mg or injected at doses of 10-30 mg, depending on the intensity of the experience desired. This can range from a mild psychedelic state to a profound and immersive experience, in which the user may feel as if they have communicated with alternative life-forms in a separate dimension [16, 17].
When vaporized or injected, the effects are rapid and begin within seconds and peak within 2 minutes. In less than half an hour, users return to baseline (with few residual effects) .
DMT is thought to play a role in relieving anxiety and improving mood. This is due to its activation of serotonin receptors (5-HT1A, 5-HT2A, and 5-HT2C), a site of action for many modern antidepressants and antianxiety medications [7, 2].
It is also thought to relieve anxiety by activating the trace amine (TA) receptors, which are involved in emotions and mood .
Psychological Effects of DMT
Although the psychological effects of DMT vary amongst users, there is generally some consistency in them. A number of effects can occur, most notably :
- Emotional arousal
- Visual hallucinations
- Perceptions of autonomous entities
- Time distortion
- Spiritual enhancement
- Ego death
Physiological Effects of DMT
The effects of DMT on the body include :
- Increased blood pressure
- Increased heart rate
- Dilated pupils
- Increased levels of the hormones beta-endorphin, cortisol, prolactin, growth hormone.
How is DMT Different From Ayahuasca?
Although ayahuasca contains DMT, the effects of ayahuasca and vaporized and intravenous DMT differs greatly. Vaporized and intravenous DMT are short-lived experiences (15 min) in which effects peak quickly (within 2 minutes) and then quickly taper off [21, 20].
Ayahuasca contains a mixture of plants that have other active compounds in addition to DMT, such as harmala alkaloids .
Ayahuasca also contains small compounds called β-carbolines. These compounds inhibit the enzyme MAO-A, which is responsible for breaking down DMT and the neurotransmitters dopamine, serotonin, and noradrenaline. MAO-A inhibition increases the levels of these neurotransmitters in addition to prolonging the effects of DMT. This combination modifies the feelings of euphoria and arousal of pure DMT [9, 7].
Beta-carbolines may be responsible for the anti-addictive, anti-cancer, and antidepressant aspects of ayahuasca. They are also the reason why ayahuasca may interact negatively with different drugs such as modern antidepressants (MAO inhibitors), SSRI’s, and St. John’s Wort [7, R, R].
The antidepressant role of ayahuasca has been documented and studied in clinical settings, but DMT alone has not. However, improvements in depression seen with ayahuasca use are attributed to DMT activity in combination with the action of the β-carboline compounds .
Because ayahuasca is brewed from different plants, drink composition may be different each time it is prepared. Therefore, there may be less consistency in the subjective feelings that users get. Users may feel different effects each time they try ayahuasca [9, 23].
DMT is a globally regulated substance and, therefore, there are limited studies regarding the potential health effects of vaporized or intravenous DMT in humans . The clinical studies that do exist are dose-response studies that are unable to establish any benefits for DMT.
1) May Reduce Aggression
2) May Protect Against Hypoxia
DMT has been shown to activate the Sig-1R, which is a receptor that protects against cell death and inflammation. In a cell study, DMT activated the Sig-1R and increased the survival of neurons and immune cells that were deprived of oxygen (hypoxia) .
3) May Be Anti-Inflammatory
Sigma receptors (including Sig-1R) are found on many immune cells, suggesting they may play a role in immune function .
In immune cells (dendritic cells) that were exposed to toxins, DMT activated the Sig-1R, and reduced production of the inflammatory cytokines IL-1β, IL-6, and TNFα and increased production of the anti-inflammatory cytokine IL-10. This research suggests DMT may play a role in immune regulation and has the potential to treat autoimmune or chronic inflammatory diseases .
4) May Be Anti-Cancer
Indolethylamine N-methyltransferase (INMT) is the enzyme that synthesizes DMT. The activity of the INMT gene that makes this enzyme is greatly reduced in certain forms of cancer 
Lower INMT activity is linked to more aggressive forms of prostate cancer .
Adverse Effects And Side Effects
DMT is generally considered a safe, non-toxic drug without too many adverse effects. Due to a lack of studies, long-term adverse effects are not known.
There have been no deaths reported from the use of pure DMT. However, in people with a history of psychiatric illness, DMT can be potentially toxic and detrimental to mental health .
- Increased blood pressure, heart rate, and body temperature
- Nausea and vomiting
- Prolonged psychotic states. Some people may be more susceptible to a DMT-induced psychotic episode. The user’s current mental state and the setting they are in play a significant role in the outcome of the “trip”.
- Structural changes in the brain from prolonged use, which can lead to changes in personality.
- Panic, especially in users with a history of mental illness. However, because DMT does not last more than 20 minutes, the negative feelings of paranoia and anxiety that may be associated with a “bad trip” are typically overcome quickly.
There have been 3 reported cases in which patients suffered a long psychotic break that required hospitalization after experimenting with DMT. In all 3 cases, DMT was taken in combination with other substances and the patients had a history of psychotic symptoms [33, 36].
In the two dose-response clinical trials that have been conducted, intravenous DMT between 0.2 and 0.4 mg/kg was found to cause hallucinatory effects, while doses below 0.2 mg/kg only produced relaxation without any perceptual changes. Commonly used dosages for vaporized DMT are 20 – 50 mg .
A number of genetic variations can influence a user’s reaction to DMT. Depending on the type of variation, your genes could either increase or decrease the overall effectiveness of DMT. These genes include:
- MAO-A (Monoamine oxidase A) codes for an enzyme that breaks down DMT in the body.
- HTR2A: A gene that codes for the serotonin receptor, 5-HT2A.
- HTR2C: A gene that codes for the serotonin receptor, 5-HT2C.
- HTR1A: A gene that codes for the serotonin receptor, 5-HT1A.
- GRM2: A gene that codes for the metabotropic glutamate receptor 2. mGluR2
- SIGMAR1: A gene that codes for the sigma receptor 1.
- TAAR6: A gene that codes for the trace amine associated receptor 6.
Want to understand your variants in these genes and how they affect your mood and tendency to respond to DMT? Check out the mood DNA Wellness Report here.
“I was transported to that extremely alien-like realm that I had been to so many times before. I felt like I was being schooled on existence.”
“I did it all in one hit; before I could exhale, I was racing through a diamond geometric tunnel. I went to heaven. I went to hell. I lived every moment that has ever happened and will ever happen. I experienced life from every being. I am you and you are me; we are just living in separate meat sacks experiencing life from different perspectives. I saw colors that can’t be imagined. I experienced the most terrifying moments of my life and also the most pleasurable.”
“It is, as they say in Spanish, bastante, it’s enough – so much enough that it’s too much. Once smoked, the onset of the experience begins in about 15 seconds. One falls immediately into a trance. One’s eyes are closed and one hears a sound like ripping cellophane, like someone crumpling up a plastic film and throwing it away…At that point, one arrives in a place that defies description, a space that has a feeling of being underground, or somehow insulated and domed.”
Some users strongly disliked the experience and had bad trips:
“I cannot recall the transition to the void. There were no colors or visions, in the traditional sense. I realized immediately that I had actually poisoned myself, and this was not a DMT trip at all, this was death”
“I can still picture the entire thing in my head, and while I may not like DMT, I respect it. I went to church that Sunday for the first time in years. I feel somewhere inside now that I want to connect with God. I guess it could be that DMT awakened something inside of me, or maybe it just scared my disbelief of God out. In any case, I won’t use DMT again.”