Hydrocodone is one of the most commonly prescribed pain medications in the US. Although it is very effective for treating pain, it is also highly addictive, and widespread abuse of opioid prescriptions leads to thousands of overdoses per year. Read on to learn more about hydrocodone, the signs of abuse, and how to keep yourself safe.

Disclaimer: By writing this post, we are not recommending this drug. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the scientific and clinical literature. Please discuss your medications with your doctor.

What Is Hydrocodone?

Hydrocodone is an opioid invented in 1920 by two German scientists, originally developed to treat severe pain and cough.

Hydrocodone has adapted from codeine — another highly addictive opioid — in the hopes of creating a less-addictive alternative. Today, it is mostly sold in combination products that include additional substances (such as acetaminophen, aspirin, ibuprofen, or antihistamines) in order to further reduce the likelihood of abuse and addiction [1].

Common brand names of drugs that contain hydrocodone include Vicodin, Lorcet, and Lortab [2].

However, a study on the abuse potential of hydrocodone-based combination drugs found that these medications still have a significant potential for addiction. Therefore, one must take care when using any medication that contains hydrocodone [3].

Due to its high addiction potential, hydrocodone is classified as a schedule II narcotic by the FDA, and therefore requires a prescription for use [4].

Mechanism of Action

Hydrocodone is a central nervous system depressant that works mainly by binding to opioid receptors.

Opioid receptors are found in the brain, spinal cord, and gastrointestinal tract. They transmit pain signals to the brain and are also involved in coughing and breathing. The effects of opioids on the nervous system involve several different types of opioid receptors [5]:

  • Delta receptors (in the limbic regions)
  • Mu receptors (involved in pain signaling)
  • Kappa receptors (throughout cortex)
  • Sigma receptors

The peak effects of a single hydrocodone dose usually occur 60 to 90 minutes after ingestion. People who abuse hydrocodone often crush and snort the pills to speed up the effects, although this greatly increases the risks of negative effects [6].

The effects of hydrocodone typically last around 4 hours, with some “extended release” pills that can last for up to 12 hours. However, these estimates are based on the average person and vary between individuals [7].

Medical Uses of Hydrocodone

1) Pain Management

The effectiveness of hydrocodone in reducing and managing pain has been established by a large number of scientific studies.

Twenty patients with cancer experienced pain relief when given oral doses of hydrocodone every 4 hours. This study also showed similar pain relief effectiveness between hydrocodone and morphine, with older patients requiring smaller doses to achieve similar effects [8].

A study in patients with chronic pain found that daily use of hydrocodone significantly improved pain intensity and quality of life [9].

A comparative study indicated that hydrocodone reduced pain in chronic pain patients as effectively as oxycodone [10].

Hydrocodone was able to maintain pain management in chronic pain patients that had formerly taken a mix of hydrocodone and acetaminophen [11].

In a study on pain management, hydrocodone improved pain, sleep patterns, and ability to perform daily activities in a group of 728 patients with moderate to severe chronic pain [12].

Hydrocodone reduced pain in 19 out of 26 patients in a study on individuals with chronic pain who had recently stopped using morphine [13].

A study in patients dealing with severe chronic lower back pain found that hydrocodone significantly reduced pain [14].

2) Cough Suppressant

Hydrocodone reduced coughing frequency by an average of 70% in a study on patients with advanced stages of cancer [15].

Studies show hydrocodone in combination with either propofol or midazolam reduces coughing during medical airway exams [16, 17].

Recreational “Uses” of Hydrocodone

Hydrocodone is frequently abused for its “positive” (pleasurable) effects, which often lead many users to become addicted. These effects include [18]:

The addictiveness of the drug stems from its ability to activate the brain’s reward system, which causes the user to feel pleasure [18].

However, this effect can easily lead to addiction, because the euphoria felt from the initial use is temporary and becomes weaker over subsequent uses. The individual gradually develops a tolerance to the chemical, and continually chases a “high” that the medicine will never again provide for them [19].

Side Effects

Whether it is used for a medical purpose or abused recreationally, hydrocodone has many potential negative effects, including [20]:

  • Mood changes
  • Headaches
  • Dry mouth
  • Blurred vision
  • Constipation
  • Dizziness
  • Nausea
  • Drowsiness
  • Elevated blood sugar levels (hyperglycemia)
  • Shallow breathing (respiratory depression)
  • Slowed heart rate (bradycardia)
  • Impaired cognition
  • Impaired consciousness
  • Seizures (during overdose)


With hydrocodone being the main ingredient in the most commonly prescribed medications in the US, a large population of abusers suffering from opioid addiction is inevitable [18].

Addiction causes compulsive drug use, drug craving and obsession, and uncontrollable drug-seeking behavior. The addiction becomes more severe the longer the drug is used, and also makes the withdrawal process more unpleasant and difficult.

The most common symptoms of opioid withdrawal include [21]:

  • Anxiety
  • Depression
  • Vomiting
  • Fatigue
  • Irregular heart rate
  • A headache
  • Suicidal thoughts

Some ways to reduce the likelihood of addiction include [22, 23]:

  • Using hydrocodone for medical purposes only
  • Checking in with your doctor frequently
  • Paying attention to the details of your prescription (dose frequency, amount, etc.)
  • Avoiding hydrocodone if you have a history of addiction to alcohol or other drugs


Users of hydrocodone often develop tolerance to the drug, which causes the same dose to have smaller and less noticeable effects the longer it is used. This results in the individual having to increase their dosage over time to maintain the same level of effects.

Using opioids can also lead to “cross-tolerance,” where tolerance to one opioid results intolerance to other types as well. This makes it more difficult to achieve the original effectiveness of pain relief, even when switching to other opioid medications [19].


Due to its addictive nature, addiction and withdrawal can occur regardless of whether it is being used legally or illegally. For this reason, even individuals who take the drug purely for medical purposes can experience withdrawal after ending use and therefore have to be closely managed by a doctor when stopping treatment [19].

Medical professionals prescribing hydrocodone, therefore, prescribe a dosage frequency that slowly decreases toward the end of the treatment in order to avoid a sudden “cold turkey” scenario [24].

Common symptoms of hydrocodone withdrawal include [21]:

  • Anxiety
  • Headaches
  • Mood swings
  • Depression
  • Impaired attention/ability to focus
  • Fatigue
  • Inability to feel pleasure (anhedonia)
  • Agitation and restlessness
  • Night Sweats
  • Suicidal thoughts
  • Drug craving
  • Muscle aches
  • Sleep difficulties
  • Sweating
  • Chills/sudden changes in body temperature
  • Vomiting
  • Diarrhea
  • Elevated blood pressure
  • Irregular heart rate

Withdrawal can begin as soon as 6 to 12 hours after the last dose is taken, and withdrawal symptoms reach their peak at around 72 hours from the last dose. The withdrawal process can last anywhere from 1 week to several months, depending on how long the user was taking the drug, as well as the size of the doses they were taking [R].

The detox procedure typically lasts a week and is best done under direct medical supervision at a detox clinic to avoid severe medical side effects.

Detoxing frequently involves using other medications to manage the symptoms of withdrawal, such as naltrexone, buprenorphine, and methadone [25].

Buprenorphine is a partial opioid agonist, meaning it also has the possibility for addiction; this drug should be taken with caution [26].


Thousands of people die every year from opioid overdoses, which are most often caused by recreational abuse. People who abuse prescription opioids often crush the drug up in order to snort it. This causes the drug to be absorbed much more quickly, making the dose more potent, while also greatly increases the risk of overdose [27].

However, overdose is always a possibility, even when taking pills that were prescribed legally in a normal manner. This is why it’s always extremely important to follow your prescription instructions carefully.

Common signs of overdose include [21]:

  • Vomiting
  • Extremely small pupils
  • Low blood pressure
  • Dizziness/lightheadedness
  • Confusion/disorientation
  • Slow, shallow, or interrupted breathing (respiratory depression)
  • Cold, clammy skin
  • Pale skin (especially in the face)
  • Bluish lips and nails
  • Limpness
  • Unconsciousness or unresponsiveness
  • Seizures

If you think someone is overdosing, it is important to call 911 immediately. Meanwhile, make sure the individual is kept awake and in an upright position while waiting for help to arrive. Above all, the most important thing is to prevent the person from losing consciousness.

A common method of treating overdoses is giving the patient naloxone. Although it is not clear whether naloxone simply competes for the same receptors, or whether it actively removes opioids from occupied receptors, the drug nonetheless quickly reverses the effects of opioids when given to overdosing patients [28, 28].

If the medication involved in the overdose contained acetaminophen as well, acetylcysteine (Mucomyst) can also be effective [29, 30].


They include [31]:

  • Any past hypersensitivity to hydrocodone or any ingredients in the formulations
  • Past history of respiratory depression
  • Any current or past gastrointestinal obstruction (opioids can cause constipation)
  • Asthma (opioids can cause respiratory depression)

Pregnancy and Breastfeeding

Women who use opiates while pregnant are at risk of making their unborn baby addicted, which can cause their children to go into drug withdrawal after birth (a condition called neonatal withdrawal).

If taking opiates is absolutely necessary to manage pain during pregnancy, opiate doses should be kept as low as possible, and should only be used under ongoing medical supervision [32].

Hydrocodone can also be passed on to a child through breast milk. It was observed that babies received about 3% of the dose taken by the mother through breast milk. For this reason, nursing mothers should limit their dose to 30 mg/day or less [33].

Drug Interactions

Hydrocodone can interact negatively with many other drugs, making them highly dangerous when mixed.

Hydrocodone can interact with:

  • Sedatives: Taking hydrocodone together with sedatives (such as alcohol, Valium, or lorazepam) can prolong and strengthen the effects of the sedatives, and can also increase the negative effects of the opioid. This results in a much greater risk of overdosing [34].
  • Tryptophan: Tryptophan can increase serotonin production in the brain, which can cause serotonin syndrome [35].
  • St. John’s Wort: Taking this herbal medication with any opiate will reduce the effectiveness of the opioid. This can lead individuals to increase their dosage of the drug, which significantly increases the chances of overdosing [36].

Hydrocodone can also interact with pre-existing medical conditions, including:

  • Asthma/respiratory issues: Compared to regular asthma patients, those with opiate addictions have a higher frequency of sudden death [37].
  • Serotonin syndrome: Having too much serotonin in the brain can lead to symptoms such as agitation, confusion, and muscle breakdown. Serotonin syndrome can be caused by mixing opiates like hydrocodone with other substances that affect serotonin levels (such as tryptophan or SSRI antidepressant medications) [38, 39].

Hydrocodone and Alcohol

Alcohol and hydrocodone are both nervous system depressants that increase each other’s effects when taken together. This makes combining them extremely dangerous, and this combination should always be avoided [34, 34].

Because of their similar effects on the brain, a history of alcoholism or alcohol abuse is a strong risk factor for hydrocodone abuse and addiction. For this reason, people who have had problems with alcohol use should probably avoid opioids altogether [22].

Does Hydrocodone Harm the Liver?

There is no solid evidence that hydrocodone causes damage to the liver when it is taken alone. However, many popular forms of hydrocodone (such as Vicodin) include other compounds such as acetaminophen, and there is some evidence that these additives may contribute to liver damage [40].


A typical dose of hydrocodone is one 10 mg dose per day, combined with 100 mg of acetaminophen [41].

However, hydrocodone dosage varies from person to person, and patients should follow the advice of the prescribing physician.

Drug Testing

Hydrocodone can be detected by urine and blood tests for anywhere from 6 to 48 hours after ingestion. After that, it is in amounts small enough to be undetectable [42].

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The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.