Evidence Based This post has 47 references
4.6 /5
1

Potential Myricetin Benefits + Sources & Side Effects

Written by Aleksa Ristic, MS (Pharmacy) | Last updated:
Jonathan Ritter
Puya Yazdi
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology), Puya Yazdi, MD | Written by Aleksa Ristic, MS (Pharmacy) | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

All of our content is written by scientists and people with a strong science background.

Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

Myricetin is a natural substance found in many vegetables and fruits. It is a good antioxidant and anti-inflammatory with a range of potential benefits for the heart, brain, skin, and more. However, there isn’t a single clinical trial to confirm its effectiveness as a supplement. Read on to learn the benefits, food sources, and side effects of myricetin.

What is Myricetin?

Myricetin, also known as myricetol, is a naturally occurring compound that belongs to the group of chemicals known as flavonoids. Flavonoids are known for their antioxidant properties. Myricetin stands out in this group as a particularly strong antioxidant [1].

A variant of myricetin (dihydromyricetin or ampelopsin) likely gives the oriental raisin tree its “anti-hangover” properties. The oriental raisin tree has been used as a hangover cure, as it reduces the alcohol levels in the blood [2].

Myricetin is also attached to many sugar storing molecules in plants (glycosides). Glycosides in flowers of Roselle are beneficial for patients with high blood pressure, as they reduce blood pressure.

Snapshot

Proponents:

  • May protect the brain and heart
  • May help with diabetes
  • May have anticancer properties
  • May improve skin health and eyesight

Skeptics:

  • Not a single clinical trial
  • May interact with certain drugs
  • Long-term safety unknown

Sources

Myricetin occurs naturally in many vegetables and fruits along with other edible parts of plants. Red wine also contains myricetin [3].

Good sources of myricetin include:

  • Oranges [4]
  • Blueberry leaves [5]
  • Japanese raisin tree (oriental raisin tree) [2]
  • Grapes (grape seeds) [6]
  • Broccoli [7]
  • Cabbage [7]
  • Peppers (red chili, green chili, bell peppers) [7]
  • Garlic [7]
  • Cashew (shoots) [7]
  • Guava [7]
  • French beans [7]
  • Tomato [7]
  • Apple [7]
  • Green and black tea [3]

Mechanism

Myricetin interacts with enzymes and suppresses their activities (enzyme inhibition).

It inhibits phosphodiesterase enzymes (PDE), which are involved in inflammatory responses against injuries or toxins [8].

Myricetin also blocks aromatase, an enzyme that converts testosterone into estrogen. Due to this effect, scientists have studied it for breast cancer prevention [9, 10].

Antioxidant Effects

Myricetin, like all flavonoids, has strong antioxidant properties [11, 12].

In a test tube study, the antioxidant activity of myricetin increased in the presence of ascorbic acid and iron [13].

Anti-Inflammatory Effects

Myricetin prevents human platelets (blood cells) from clotting, which is an important step in the inflammation process [14].

It also suppressed protein kinase enzymes, many of which act as signaling molecules during inflammation [15].

Myricetin also inhibited snake venom PLA2, which causes inflammation and pain [16].

Based on these effects, scientists are researching myricetin for chronic inflammatory disorders like rheumatoid arthritis and atopic dermatitis [16].

Potential Health Benefits of Myricetin

Animal and Cellular Research (Lacking Evidence)

No clinical evidence supports the use of myricetin for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based studies; they should guide further investigational efforts but should not be interpreted as supportive of any health benefit.

1) Anticancer Properties

Myricetin was able to kill cancer cells and inhibit the growth of pancreatic cancer in lab animals [17].

Since myricetin is a good antioxidant, it protects DNA from oxidative damage, which greatly contributes to cancer development [18, 19].

However, it can also act as a pro-oxidant in the presence of certain ions such as copper. In this form (myricetin-copper complexes), myricetin is toxic to cancer cells causing cell death (apoptosis). Copper-myricetin complexes produce reactive oxygen species that break DNA in cancer cells [20, 21].

Cisplatin, in combination with myricetin, increased inhibition of cancer cell growth and increased cell death compared to cisplatin by itself [22].

In test tubes, myricetin suppressed cervical, brain, blood, prostate, colon, and other types of cancer cells [23, 24, 25, 26, 27].

The above research is promising, but it doesn’t tell us anything about the actual anticancer effects of myricetin in humans. At this point, it can’t be recommended for cancer prevention or treatment.

2) Brain Protection

The progression of Alzheimer’s disease has been associated with an increased phosphorylation of tau proteins. According to cellular research, myricetin may slow down this process [23].

It also blocks β-amyloid aggregates formation, which is associated with Alzheimer’s disease [28].

Myricetin improved spatial learning in mice subjected to stress. This improvement was associated with its ability to increase BDNF in the hippocampus [29].

In cell-based studies, it increased the activity of GABA-A receptors, which play a central role in brain functions and mental health [30, 31, 32].

3) Heart Disease

In test tubes, myricetin protects the heart from impaired blood flow by inhibiting the activation of STAT-1 [33].

Myricetin treatment caused a 27% decrease in cholesterol deposition in blood vessels of guinea pigs [34].

In rats, myricetin reduced oxidative damage and high blood pressure. It also slowed down the heart rate and reduced sodium in the urine [35].

4) Diabetes

In rats, myricetin treatment decreased high blood sugar by 50% within a couple of days of treatment [36].

Myricetin also increased glucose uptake by muscles and other cells [37, 38].

5) Skin Protection

Myricetin inhibits the Fyn protein, which is associated with skin cancer in the presence of UV rays [39].

It also suppresses RAF kinase enzyme, which is responsible for wrinkle formation in the skin [40].

In test tubes, myricetin-3-O-β-rhamnoside (myricetin with an added rhamnose sugar) boosted skin regeneration and wound healing [41].

6) Eyesight

Cataracts are one of the most common eyesight problems of the elderly. Due to its antioxidant and glucose-balancing properties, myricetin prevented cataract formation in rats [42].

Myricetin protects retinal cells. Its anti-inflammatory properties may also help in relieving retinal swelling (macular edema) [43].

7) Pain

In rats, myricetin was effective at relieving pain [44].

8) Allergies

Myricetin acted as an anti-allergen in mice allergic to egg white [45].

Limitations and Caveats

The available myricetin studies were performed in test tubes, cells, or animals. In the absence of clinical evidence, myricetin can’t be recommended for any health condition.

Myricetin Side Effects & Precautions

Keep in mind that the safety profile of myricetin is relatively unknown, given the lack of clinical studies. The list of side effects below is not a definite one, and you should consult your doctor about other potential side effects, based on your health condition and possible drug or supplement interactions.

You should avoid inhaling myricetin because it may cause shortness of breath.

Protective gloves and goggles should be used when handling myricetin. It causes skin, eye, and respiratory irritation [46].

Children and pregnant women should avoid poorly researched supplements such as myricetin.

Drug Interactions

Supplement-drug interactions can be dangerous and, in rare cases, even life-threatening. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering.

Myricetin improved the uptake of tamoxifen (for cancer), doxorubicin (increased uptake only when taken orally to treat cancer), and losartan (to treat high blood pressure) [47].

The rate of increased uptake of drugs was directly related to the dose of myricetin.

User Reviews

The opinions expressed in this section are solely from the users who may or may not have a medical background. SelfDecode does not endorse any specific product, service, or treatment. Do not consider user experiences as medical advice. Never delay or disregard seeking professional medical advice because of something you have read on SelfDecode.

Most of the users are happy with the results they are getting. Users have shown satisfaction over the ability of myricetin to maintain blood pressure, weight, and blood glucose.

Some of the users had a neutral opinion after using myricetin as they weren’t sure if they were getting results specifically due to myricetin since they were using other supplements too.

No major side effects were reported.

About the Author

Aleksa Ristic

Aleksa Ristic

MS (Pharmacy)
Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets. 
Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions—writing and health—and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.

Click here to subscribe

RATE THIS ARTICLE

1 Star2 Stars3 Stars4 Stars5 Stars
(11 votes, average: 4.64 out of 5)
Loading...

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.