Myricetin is a natural substance found in many vegetables and fruits. It is a good antioxidant and anti-inflammatory with a range of potential benefits for the heart, brain, skin, and more. However, there isn’t a single clinical trial to confirm its effectiveness as a supplement. Read on to learn the benefits, food sources, and side effects of myricetin.
Myricetin, also known as myricetol, is a naturally occurring compound that belongs to the group of chemicals known as flavonoids. Flavonoids are known for their antioxidant properties. Myricetin stands out in this group as a particularly strong antioxidant .
A variant of myricetin (dihydromyricetin or ampelopsin) likely gives the oriental raisin tree its “anti-hangover” properties. The oriental raisin tree has been used as a hangover cure, as it reduces the alcohol levels in the blood .
Myricetin is also attached to many sugar storing molecules in plants (glycosides). Glycosides in flowers of Roselle are beneficial for patients with high blood pressure, as they reduce blood pressure.
- May protect the brain and heart
- May help with diabetes
- May have anticancer properties
- May improve skin health and eyesight
- Not a single clinical trial
- May interact with certain drugs
- Long-term safety unknown
Myricetin occurs naturally in many vegetables and fruits along with other edible parts of plants. Red wine also contains myricetin .
Good sources of myricetin include:
- Oranges 
- Blueberry leaves 
- Japanese raisin tree (oriental raisin tree) 
- Grapes (grape seeds) 
- Broccoli 
- Cabbage 
- Peppers (red chili, green chili, bell peppers) 
- Garlic 
- Cashew (shoots) 
- Guava 
- French beans 
- Tomato 
- Apple 
- Green and black tea 
Myricetin interacts with enzymes and suppresses their activities (enzyme inhibition).
It inhibits phosphodiesterase enzymes (PDE), which are involved in inflammatory responses against injuries or toxins .
Myricetin prevents human platelets (blood cells) from clotting, which is an important step in the inflammation process .
It also suppressed protein kinase enzymes, many of which act as signaling molecules during inflammation .
Based on these effects, scientists are researching myricetin for chronic inflammatory disorders like rheumatoid arthritis and atopic dermatitis .
No clinical evidence supports the use of myricetin for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based studies; they should guide further investigational efforts but should not be interpreted as supportive of any health benefit.
Myricetin was able to kill cancer cells and inhibit the growth of pancreatic cancer in lab animals .
However, it can also act as a pro-oxidant in the presence of certain ions such as copper. In this form (myricetin-copper complexes), myricetin is toxic to cancer cells causing cell death (apoptosis). Copper-myricetin complexes produce reactive oxygen species that break DNA in cancer cells [20, 21].
Cisplatin, in combination with myricetin, increased inhibition of cancer cell growth and increased cell death compared to cisplatin by itself .
The above research is promising, but it doesn’t tell us anything about the actual anticancer effects of myricetin in humans. At this point, it can’t be recommended for cancer prevention or treatment.
It also blocks β-amyloid aggregates formation, which is associated with Alzheimer’s disease .
In rats, myricetin treatment decreased high blood sugar by 50% within a couple of days of treatment .
In test tubes, myricetin-3-O-β-rhamnoside (myricetin with an added rhamnose sugar) boosted skin regeneration and wound healing .
Cataracts are one of the most common eyesight problems of the elderly. Due to its antioxidant and glucose-balancing properties, myricetin prevented cataract formation in rats .
Myricetin protects retinal cells. Its anti-inflammatory properties may also help in relieving retinal swelling (macular edema) .
In rats, myricetin was effective at relieving pain .
Myricetin acted as an anti-allergen in mice allergic to egg white .
The available myricetin studies were performed in test tubes, cells, or animals. In the absence of clinical evidence, myricetin can’t be recommended for any health condition.
Keep in mind that the safety profile of myricetin is relatively unknown, given the lack of clinical studies. The list of side effects below is not a definite one, and you should consult your doctor about other potential side effects, based on your health condition and possible drug or supplement interactions.
You should avoid inhaling myricetin because it may cause shortness of breath.
Protective gloves and goggles should be used when handling myricetin. It causes skin, eye, and respiratory irritation .
Children and pregnant women should avoid poorly researched supplements such as myricetin.
Supplement-drug interactions can be dangerous and, in rare cases, even life-threatening. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering.
Myricetin improved the uptake of tamoxifen (for cancer), doxorubicin (increased uptake only when taken orally to treat cancer), and losartan (to treat high blood pressure) .
The rate of increased uptake of drugs was directly related to the dose of myricetin.
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Most of the users are happy with the results they are getting. Users have shown satisfaction over the ability of myricetin to maintain blood pressure, weight, and blood glucose.
Some of the users had a neutral opinion after using myricetin as they weren’t sure if they were getting results specifically due to myricetin since they were using other supplements too.
No major side effects were reported.