Noopept is a cognitive enhancer that performs significantly better than Piracetam in dealing with emotional sensitivity after vascular or traumatic brain injuries.
It helps with a good night’s sleep, irritability, drowsiness, headaches, and to have the necessary energy to take on the day. It also helps with anxiety, memory, and stress.
Note: By writing this post, we are not recommending this drug. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the scientific literature. Please discuss your medications with your doctor.
The cognitive enhancer Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is around 1000 times stronger than piracetam [R]. Piracetam improves the early stage of the process of memory, while Noopept also improves the consolidation and retrieval stages of memory. It’s anti-anxiety, antioxidant, anti-inflammatory, and prevents neurotoxicity from amyloid excess while also improving blood flow.
Noopept crosses the blood-brain barrier and is then broken down into cycloprolylglycine, which reaches peak concentrations within 7 minutes in rats [R, R]. In humans, no cycloprolylglycine has been found, and it takes longer to hit the peak [R].
Benefits of Noopept
1) Noopept Improves Memory And Cognition
Rats receiving Noopept improved one-session learning, while after repeated administration the number of successful learners increased among those who failed initial training. Thus, Noopept improves memory and prevents amnesia [R].
2) Noopept Improves Anxiety
In rats, cycloprolylglycine (produced in the brain from Noopept) reduced anxiety, suggesting that anxiety and memory are regulated together [R].
3) Noopept Helps With Emotional Balance (after vascular or traumatic brain injuries)
In a clinical trial of 53 patients with emotional sensitivity (after vascular or traumatic brain injuries) over 56 days, Noopept (10 mg x2 per day) performed significantly better than piracetam (400 mg x3 per day).
Noopept improved anxiety, irritability, mood, energy, apathy, sleep disturbances, daytime drowsiness, and headache, some of it within the first week.
Within the 56 days for the trial, Noopept hasn’t improved mood, sleep, waking, and drowsiness.
Some of these patients had negative effects such as increased sleep issues, irritability, and an increase in blood pressure [R].
4) Noopept Prevents Stress
5) Noopept Improves Alzheimer’s And Parkinson’s
In test tube-based studies, Noopept was neuroprotective and prevented cell death from amyloid toxicity, which is the cause of Alzheimer’s and Parkinson’s symptoms [R].
Other – Uncertain
In rats with experimental type 1 diabetes, Noopept improved the production of incretin, a hormone that stimulates insulin secretion in response to meals [R].
In rats with bacterial inflammation, Noopept lowered IL-6 and TNF-alpha [R]. While in mice, there are also other immune system benefits of Noopept, such as an increased response to antigens and white blood cell growth [R].
Interestingly, Noopept in white mice increased their movement into white rooms, and the opposite effect occurred in black mice [R].
In a group of 127 healthy volunteers, Noopept improved adaptation to hot or cold environments and increased physical work capacity in hot climates [R].
Its primary mechanism of action is increasing the activity of HIF1A, a DNA transcription factor [R].
Noopept increases nerve inhibition without increasing inhibitory neurotransmitters [R].
In some mice strains, the GABA-A receptor in the prefrontal cortex produced the anti-anxiety effect, while the hippocampus NMDA receptor was mainly responsible for the nootropic effects. However, other mice strains showed no improvements [R].
In snails, Noopept suppressed the voltage-gated calcium and potassium channels used in calcium balance [R].
Also, in rats, Noopept increased Alpha/beta 1 brainwaves in all areas [R].
10-30 mg per day is what users often go with, while 20 mg was used in a clinical trial [R].
It completely prevents memory loss from scopolamine (datura) in mice [R].
Noopept Experience Reports
West-en, 30mg per day:
“[A friend] did say that the experience was like the “cognitive improvements from LSD without the hallucinations”
… memories I thought were long lost suddenly appears in a vivid fashion
… There’s one clear side effect though, and that is the irritability. I as many others, have noticed an irritability especially directed at other people
… If being drunk is a low level of existence (I actually feel like it is), this is the exact opposite.” [R].
Noopeptisgood, 20mg per day:
“I used the better part of a gram in the spring, and when I ran out of the product, I got some bad headaches.
Those faded and the positive changes in my brain persisted.
But I never experienced any withdrawal symptoms other than that.” [R].
Protoject, 30mg per day:
“Certain parts of the mind are in the ON position that was OFF before, but it isn’t overbearing, nor is it yet a super strong mind clearing effect or anything- it is a mild effect but definite.” [R].
“As for reversing marijuana induced brain damage or for reversing brain fog, I suppose you can try Noopept, but I don’t think you’d want to rely on it alone, not by a long shot. Consider piracetam too.” [R].
“Been taking it every day since Friday. Overall increase in mental energy and motivation.
If you get a headache, it is because you are taking too much and/or do not have enough acetylcholine in your brain.
With caffeine, it makes me feel like I am on a high dose of Adderall and strengthens the appetite suppression.” [R].
“Update: the effects of Noopept are certainly cumulative, though I don’t know when it actually starts to hit a peak and stay there.
At the moment its a bit too good to be true, my motivation and focus has drastically increased.
I managed to get my ass off and construct a website over the weekend (something i’ve been putting off a while), I also seem to be much more able to do unpleasant things that require doing.
My vision/focus seems enhanced, my memory is slightly better but not a drastic improvement.
Also, my sleep has normalized which is a dream come true, again I have a feeling this gravy train won’t last, it’s just too good to be true.
My energy level is much more stable, instead of it suddenly going up then crashing down. I am hoping I will reap more benefits as more days go by.
On the other hand my verbal fluency has decreased as has my creativity and ability to day dream, my personality is colder, whilst my visual recall and imagination seems to be slightly improved it seems to come at a cost of not being able to be emotional/emotive, there is definitely a sexual side effect of being less stimulated and less semen production” [R].
“I had to stop taking Noopept after 20 days of dosing at just 2x10mg per day as I was getting that pulsing feeling and a random medical check up showed elevated blood pressure of 149/99, after a week off from Noopept my blood pressure returned to normal” [R].
Noopept has side effects such as headaches, dizziness, and tiredness, which are usually associated with low blood pressure. But, in this case, high blood pressure is the cause of these negative effects.
“I’ve been taking noopept & alpha-gpc for nearly two years. It’s a delicate balance I have to feel my way into the correct dose for the day. Sometimes I know to take more alpha-gpc, other times I know to take half dose of noopept.” [R]
A 6-month treatment in rabbits at 100 mg/kg body weight found no toxic effects [R]. Although, reports in humans include headaches, dizziness, sleep, and high blood pressure. It varies from person to person.
One vendor lists Noopept with the risk that overdosing may lead to glutamate toxicity. I think it’s more to do with acetylcholinesterase inhibition [R].