Noopept is a potential cognitive enhancer that is significantly better than piracetam in dealing with emotional sensitivity after vascular or traumatic brain injuries. Studies in humans are lacking, however, noopept may help with sleep, irritability, drowsiness, headaches, anxiety, memory, and stress. Read on to find out more about noopept.
What is Noopept?
Noopept is around 1,000 times stronger than piracetam. Piracetam affects the early stage of memory processing, while noopept also improves the consolidation and retrieval stages of memory. It may also have anti-anxiety, antioxidant, anti-inflammatory, and neuroprotective properties from amyloid excess while also improving blood flow [R].
Potential Benefits and Uses of Noopept
1) Helps With Emotional Balance
In a clinical trial of 53 patients with emotional sensitivity (after vascular or traumatic brain injuries), noopept (10 mg 2 times per day) performed significantly better than piracetam (400 mg 3 times per day) [R].
Noopept improved anxiety, irritability, mood, energy, apathy, sleep disturbances, daytime drowsiness, and headache, some of it within the first week [R].
Within the 56 days for the trial, Noopept hasn’t improved mood, sleep, waking, and drowsiness [R].
Some of these patients had negative effects such as increased sleep issues, irritability, and an increase in blood pressure [R].
2) May Improve Memory And Cognition
Rats receiving Noopept improved one-session learning, while after repeated administration the number of successful learners increased among those who failed initial training. Thus, Noopept improves memory and prevents amnesia [R].
3) May Improves Anxiety
In rats, cycloprolylglycine (produced in the brain from Noopept) reduced anxiety, suggesting that anxiety and memory are regulated together [R].
4) May Prevent Stress
5) May Improve Alzheimer’s And Parkinson’s
In test tube-based studies, Noopept was neuroprotective and prevented cell death from amyloid toxicity, which is the cause of Alzheimer’s and Parkinson’s symptoms [R].
In rats with experimental type 1 diabetes, noopept improved the production of incretin, a hormone that stimulates insulin secretion in response to meals [R].
In rats with bacterial inflammation, noopept lowered IL-6 and TNF-alpha. While in mice, there are also other immune system benefits of noopept, such as an increased response to antigens and white blood cell growth [R, R].
Interestingly, noopept in white mice increased their movement into white rooms, and the opposite effect occurred in black mice [R].
In a group of 127 healthy volunteers, noopept improved adaptation to hot or cold environments and increased physical work capacity in hot climates [R].
How Does Noopept Work?
The exact mechanism of noopept is not fully understood. After chronic intake, noopept increases NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) in rat hippocampus and hypothalamus [R, R].
Its primary mechanism of action is increasing the activity of HIF1A, a DNA transcription factor [R].
Noopept increases nerve inhibition without increasing inhibitory neurotransmitters [R].
In some mice strains, the GABA-A receptor in the prefrontal cortex produced the anti-anxiety effect, while the hippocampus NMDA receptor was mainly responsible for the nootropic effects. However, other mice strains showed no improvements [R].
In snails, noopept suppressed the voltage-gated calcium and potassium channels used in calcium balance [R].
Also, in rats, noopept increased alpha/beta 1 brainwaves in all areas [R].
Risks and Side Effects
Noopept has side effects such as headaches, dizziness, and tiredness, which are usually associated with low blood pressure. But, in this case, high blood pressure is the cause of these negative effects
10 – 30 mg per day is what users often go with, while 20 mg was used in a clinical trial [R].
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