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12 Amazing Lactobacillus Salivarius Benefits (Probiotic)

Written by Biljana Novkovic, PhD | Last updated:
Jonathan Ritter
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology) | Written by Biljana Novkovic, PhD | Last updated:

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Lactobacillus Salivarius

L. salivarius is great for your dental and overall health, relieves allergies and asthma, lowers cholesterol, and fights cancer.

What is Lactobacillus salivarius?

Lactobacillus salivarius is one of the most prevalent species in human saliva. It produces organic acids, such as lactic acid and acetic acid from carbohydrates, which can inhibit the growth of surrounding microorganisms, and produces hydrogen peroxide and other antimicrobial substances [1]. This bacterium stimulates the immune system, alleviates intestinal disease and promotes well-being [2].

Health Benefits of L. salivarius

1) Antibacterial

L. salivarius produces a bacteriocin, an antimicrobial substance, that can significantly protect mice against infection with the invasive foodborne pathogen Listeria monocytogenes [3].

2) Beneficial for Dental Health

L. salivarius beneficially changed the bacterial population of gum plaque in volunteers [4].

L. salivarius increases resistance to caries risk factors [5].

Oral administration of L. salivarius improved bad breath, showed beneficial effects on bleeding on probing from the periodontal pocket, and inhibited the reproduction of “bad” bacteria [6, 7, 1, 8].

Periodontal clinical parameters especially improved in smokers [9].

However, one study suggests that L. salivarius itself may possess an inherent cariogenic activity following adherence to the tooth surface [10].

3) May Combat H. pylori

L. salivarius suppresses H. pylori and reduces infection-induced inflammatory responses in mice [11].

This inhibition is strain specific, though, and a study showed that 9 out of the 28 L. salivarius strains tested inhibited H. pylori growth [12].

4) May Relieve GI Inflammation

L. salivarius facilitates the recovery of the inflamed tissue in rat colitis, by ameliorating the production of inflammatory mediators, such as cytokines, including TNF-α and NO [13].

5) Beneficial in Obesity

L. salivarius increases the ratio of beneficial bacteria (Bacteroides, Prevotellae, and Porphyromonas) to Firmicutes-belonging bacteria in obese adolescents [14].

6-week supplementation of L. salivarius along with fructooligosaccharide (FOS) significantly reduced total cholesterol, “bad” (LDL) cholesterol, and triglycerides, and increased “good” (HDL) cholesterol in humans. Blood inflammatory markers were also significantly reduced [15].

6) May be Beneficial in Diabetes

Treating diabetic mice with dead L. salivarius reversed gut microbial imbalance, restored mucosal antibacterial protein and lessened endotoxin levels [16].

7) Stimulates Liver Function

Pretreatment with L. salivarius improves acute liver injury in rats [17].

L. salivarius exerts a good health-promoting effect in acute liver failure [18].

8) Enhances the Immune Response

L. salivarius enhanced both natural and acquired immune responses [19].

Daily administration of L. salivarius to healthy adults is safe and improves gut microbiota and different parameters related to immune response [20].

9) Combats Dermatitis

L. salivarius improves symptoms in children [21, 22], and adults with atopic dermatitis [23].

10) Alleviates Asthma

L. salivarius decreases allergen-induced airway response in mice [24].

L. salivarius can alleviate the clinical symptoms, airway hyperreactivity and airway inflammation in mice with asthma [25].

L. salivarius decreases the secretion of proinflammatory cytokines and shows beneficial immunomodulatory activity in asthmatic subjects [26].

11) Combats Cancer

L. salivarius suppresses colon carcinogenesis in rats [27].

L. salivarius kills oral cancer cells and inhibits cancer growth in rats [28].

12) Prevents Breast Infection in Pregnancy

Oral administration of L. salivarius during late pregnancy appears to be an efficient method to prevent breast infection in pregnant women [29].


  • L. salivarius reduces inflammatory markers such as hs-CRP, interleukins IL-6, IL-1β, TNFα and TGF-β [15, 26].
  • L. salivarius reduces elevated ALT, AST and total bilirubin [17].
  • L. salivarius increases IL-10 and /or IFNγ [17, 26].
  • L. salivarius improves the Th1/Th2 balance in asthma mice [25].
  • L. salivarius reduces eosinophil influx, IgE and eotaxin in asthma [24].


L. salivarius was shown to be nonpathogenic for mice, even in doses 10,000 times higher than those normally consumed by humans [30].

A formula with L. salivarius was shown to be safe and well tolerated in human clinical trials [20], including a trial with 6-month-old infants [31].

Use in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms should be avoided as it can lead to infections.

Buy Lactobacillus salivarius

These probiotic products contain L. salivarius:

This section contains sponsored links, which means that we may receive a small percentage of profit from your purchase, while the price remains the same to you. The proceeds from your purchase support our research and work. Thank you for your support.

About the Author

Biljana Novkovic

Biljana Novkovic

Biljana received her PhD from Hokkaido University.
Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. She is passionate about releasing the most accurate science and health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. She believes that SelfHacked has the best science that is also layperson-friendly on the web.

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