Evidence Based This post has 53 references
0

Manganese Deficiency Symptoms & Causes + Food Sources

Written by Puya Yazdi, MD | Last updated:
Ognjen Milicevic
Medically reviewed by
Ognjen Milicevic, MD, PhD | Written by Puya Yazdi, MD | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

All of our content is written by scientists and people with a strong science background.

Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

Manganese deficiency

Manganese deficiency is very rare because most people get plenty in their diets. However, it does rarely happen in people with certain gene mutations. Read on to find out more about manganese deficiency, the health effects of low manganese levels, and foods high in manganese that boost your levels safely.

What is Manganese?

Manganese is a trace mineral essential to all forms of life. It is required for the normal development, growth, and function of our bodies [1, 2, 3].

Manganese serves as an essential part of important enzymes, including mitochondrial superoxide dismutase [4, 2].

These enzymes play a role in:

  • Energy (ATP) production in mitochondria [4]
  • Fat, protein, and sugar metabolism [1, 2]
  • Brain development and function [5]
  • Bone and connective tissue production [2, 6]
  • Immune response [2]
  • Sex hormone production and reproductive function [2, 6]
  • Digestion [4]
  • Antioxidant defense [7]

Manganese is found pretty much everywhere: in the air, water, and soil. We readily ingest it through food and water. That’s why manganese deficiency is basically unheard of [8].

But while it is a required part of a healthy diet, exposure to excess levels can be toxic [8].

Want to learn more about the benefits and function of manganese in a healthy body? Check out our post here.

Normal Levels

Normal ranges of manganese for adults are [8]:

  • 4-15 μg/L in blood (that is equal to 72.8 – 273 nmol/L)
  • 0.4-0.85 μg/L in serum (the liquid component of blood)
  • 11-23 ug/L in red blood cells (RBC manganese)
  • 1-8 μg/L in urine

Seniors have slightly lower manganese levels compared to other age groups, likely due to lower gut absorption [9].

Blood, urine, and saliva levels are poor indicators of manganese exposure or of total manganese present in the whole body [10, 11, 12].

RBC (red blood cell) manganese levels are a better measure of the actual content of manganese in tissues. They can help estimate recent exposure to manganese, spanning a couple of months before the test [13, 14].

For those worried about toxicity due to long-term, low-dose manganese, hair, nail, and bone manganese content may give a more accurate exposure estimate [15, 10].

However, the uses of both hair and nail manganese tests are limited. People naturally have a large variation between them, and hair and nails are especially prone to contamination from shampoo, nail polish, dust, dirt, and other external factors [16].

Normal manganese levels in the blood are 4-15 ug/L. Red blood cell manganese helps estimate recent exposure, while bone testing may be more accurate for long-term exposure.

Manganese Deficiency

Manganese deficiency is very rare, as sufficient amounts of this nutrient are present in most diets [2, 17].

In fact, this condition is so rare that, for a long time, only a few vaguely described cases existed in the medical literature [18, 19].

That was until 2015, when a rare genetic mutation in a manganese uptake transporter gene (SLC39A8) was discovered [20, 21].

Possible Causes

Genetic Deficiency

SLC39A8 serves as a transporter for metals such as manganese, iron, zinc, and cadmium, meaning that it transports these metals into cells. People with mutations in this gene have low blood manganese levels. Zinc levels have been low in some patients, but normal in others [22].

Infants and children with these mutations experience [23, 22]:

  • Severe developmental delay
  • Short stature (dwarfism)
  • Low muscle tone (hypotonia)
  • A movement disorder resembling tremors (dystonia)
  • Seizures
  • Intellectual disability
  • Inability to align the eyes (strabismus)
  • Deafness
  • Failure to thrive

Mutations in this gene are associated with [23, 22]:

  • Leigh-like mitochondrial disease, because the enzyme MnSOD (manganese superoxide dismutase) stops working in the absence of manganese, which damages the mitochondria.
  • Type II congenital glycosylation disorder, because manganese is needed for the function of an enzyme that adds sugar residues to proteins and fats (β-galactosyltransferase).

In these cases, manganese supplementation normalized enzyme function and helps improve motor function, hearing, and other neurological issues. To avoid toxicity during treatment, doctors regularly monitor blood manganese levels and conduct MRI brain imaging to detect possible manganese buildup [24, 22].

Dietary Deficiency

When seven men were experimentally placed on a manganese-depleted diet for over a month, they experienced a transient skin rash and decreased blood cholesterol levels. In addition, blood calcium, phosphorus, and alkaline phosphatase (ALP) levels rose, possibly due to increased bone breakdown [25].

That said, most of what we know of dietary manganese deficiency comes from animal studies. In animals, low dietary manganese impairs growth, prevents proper bone formation and causes skeletal defects, decreases glucose tolerance, and impairs fat and carb metabolism [26, 27].

Manganese deficiency due to diet is extremely rare and has never been reported in humans. There are a handful of cases of deficiency due to genetic causes.

Symptoms

Potential symptoms of low manganese (not due to genetic reasons) include:

  • Weakness [2]
  • Skin lesions [19]
  • Increased susceptibility to seizures [2, 28, 29]
  • Defective insulin production [30]
  • Impaired fertility [31]
  • Weaker bones [2]

Because of the rarity of manganese deficiency, these symptoms are more likely to be produced by another underlying condition. If you suffer from symptoms like these, we strongly recommend talking to your doctor, who will order the appropriate tests and make an accurate diagnosis.

Conditions

Several studies have investigated the effects of low (but not deficient) manganese.

Lower manganese levels have been linked to:

However, it’s important to note that higher manganese levels are also associated with many of the same conditions. In fact, manganese levels often have a U- or inverse U-shaped relationship with many conditions: the highest and lowest levels are detrimental and the mid-range beneficial.

In addition, low manganese is may be an effect of certain diseases and disorders, rather than the cause.

Finally, low manganese levels have been observed in some people with:

  • Osteoporosis [19]
  • Epilepsy [19]
  • Perthes’ disease, a rare childhood condition [46]
  • Exocrine pancreatic insufficiency (lack of digestive enzymes made by the pancreas) [47]
  • Phenylketonuria [47]
  • Kidney disease undergoing hemodialysis [47]

But these are isolated cases. In other words, not all people suffering from these diseases have low manganese levels. Therefore, manganese deficiency in these diseases is not considered a health concern, but it may be worth asking your doctor about your manganese levels occasionally if you’re worried.

Ways to Increase Manganese

Because it’s very easy to overdo manganese, the best way to increase your levels is through a healthy, plant-based diet. Get more legumes, nuts, and whole grains like brown rice or whole wheat bread [48, 7].

Intake of higher amounts of iron, calcium, and phosphorus (from food or supplements) may prevent manganese absorption [49]. Be careful not to take excessive amounts of these other minerals [49].

Foods High in Manganese

We get most of our manganese through diet. The highest levels of manganese can be found in [48, 7, 2, 31]:

Food SourceManganese per 100 g
Legumes (lima beans)0.36 mg
Nuts (pine nuts)8.8 mg
Nuts (macadamia nuts)4.0 mg
Whole grains (wheat germ)20 mg
Whole grains (brown rice)1.0 mg
Whole wheat bread1.0 mg
Seafood (mussels)3.4 mg
Seeds (pumpkin seeds)0.5 mg
Chocolate (dark chocolate)1.5 mg
Tea (brewed black tea)0.2 mg
Leafy green vegetables (spinach)0.9 mg
Spices (cloves)More than 60 mg
Soybeans0.55 mg
Pineapple0.9 mg
Blueberries0.34 mg
Acai (acai berry drink)1.66 mg

 

The adult dietary intake of manganese is normally anywhere from 0.9 to 10 mg per day, while the US National Research Council has established an estimated safe and adequate dietary intake of 2–5 mg/day for adults [50, 5, 31, 51].

People eating vegetarian diets and Western-type diets may have manganese intakes as high as 10.9 mg/day, which is close to the upper safe limit from all sources [52].

You can get all the manganese you need through your diet. Foods high in manganese include legumes, nuts, and whole grains.

Manganese Supplementation

Most people already have more than an adequate intake of manganese and should be careful when supplementing this metal. There are various manganese supplements available on the market. Multivitamins, for example, often include it.

Manganese supplements usually contain 5-20 mg. Bear in mind that 11 mg/day is often cited as the upper limit for no observed adverse effects; this is one reason why it’s especially important to talk to your doctor before supplementing with manganese [50].

Around the web, manganese is discussed as a histamine-lowering and dopamine-increasing agent, although there is little research to support this. In fact, tissue and animal studies suggest that manganese may actually decrease dopamine in the long run [19, 53].

User Experiences

According to users, manganese supplements caused a short-term boost in energy, but people often report side effects such as emotional instability, mood issues, racing pulse, nausea, and fatigue.

As a plant-rich diet provides more than enough manganese for most of us, you may want to skip manganese and opt for other supplements that can provide the same benefits but without the toxic effects.

Most people have no need to supplement with this metal. If you do choose to supplement, talk to your doctor first and be wary of the toxic effects of high manganese levels.

Takeaway

Manganese deficiency is extremely rare, and most people get plenty from plant-based foods like legumes, leafy green vegetables, and whole grains. Rare genetic mutations in the manganese transporter can cause severe developmental delay, short stature, seizures, and other symptoms. Manganese supplementation can be used to manage this condition.

Very low or very high manganese are linked with cognitive deficits and metabolic problems, so it’s important to keep manganese consumption in balance. If you suspect your manganese is low, eating manganese-rich food is usually better than supplementation. When in doubt, talk to your doctor.

About the Author

Puya Yazdi

Puya Yazdi

MD
Dr. Puya Yazdi is a physician-scientist with 14+ years of experience in clinical medicine, life sciences, biotechnology, and nutraceuticals.
As a physician-scientist with expertise in genomics, biotechnology, and nutraceuticals, he has made it his mission to bring precision medicine to the bedside and help transform healthcare in the 21st century.He received his undergraduate education at the University of California at Irvine, a Medical Doctorate from the University of Southern California, and was a Resident Physician at Stanford University. He then proceeded to serve as a Clinical Fellow of The California Institute of Regenerative Medicine at The University of California at Irvine, where he conducted research of stem cells, epigenetics, and genomics. He was also a Medical Director for Cyvex Nutrition before serving as president of Systomic Health, a biotechnology consulting agency, where he served as an expert on genomics and other high-throughput technologies. His previous clients include Allergan, Caladrius Biosciences, and Omega Protein. He has a history of peer-reviewed publications, intellectual property discoveries (patents, etc.), clinical trial design, and a thorough knowledge of the regulatory landscape in biotechnology.He is leading our entire scientific and medical team in order to ensure accuracy and scientific validity of our content and products.

Click here to subscribe

RATE THIS ARTICLE

1 Star2 Stars3 Stars4 Stars5 Stars
(1 votes, average: 5.00 out of 5)
Loading...

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.