Vitamin B2 is effective for riboflavin deficiency, migraine headaches, lowering the risk of developing cataracts and cardiovascular diseases.

What is Vitamin B2?

Vitamin B2, also known as Riboflavin, is a vitamin that plays an integral role in the body as it helps with B6 metabolism and can help combat different disorders.

It plays a vital role in the human body by working with other micronutrients.

Health Benefits of Vitamin B2

1) Anti-inflammatory 

Riboflavin significantly reduces the expression of HMGB1 (high-mobility group protein B1), which is one of the factors responsible for inflammation in systemic inflammatory response syndrome (sepsis) in mice (R).

Under various circumstances, it shows anti-inflammatory properties (R).

2) Cognitive Function

Riboflavin is associated with improved cognitive test scores in primary school children in rural Kenya (R).

Higher dietary intake of riboflavin is associated with better abstract performance (R).

Riboflavin is a safe and well-tolerated option for treating migraines in adults (R). It reduced the number of times migraines occur (R1, R2).

Riboflavin treatment in a 16-year-old boy with L-2-hydroxyglutaric aciduria (LHGuria), a rare neurometabolic disorder improved his cognitive function (R).

3) Depression 

In many depressed subjects, there was a concurrent Riboflavin deficiency (R).

In elderly, depressed patients, B vitamins (B1, B2, and B6) improved depression (R).

In a Japanese cross-sectional study, increased dietary intake of Riboflavin meant decreased symptoms of depression in girls but not for boys (R).

Consumption of Riboflavin prevents depression after childbirth (R).

4) Eye Health

Increased dietary consumption of Riboflavin leads to a significant decrease in age-related cataracts (R).

Consumption also leads to less age-related opacity in the eyes (R).

Combined use of Riboflavin and UVA photochemical therapy has a positive effect in patients with eye inflammation (R1R).

5) Cardiovascular Disease

In a patient with a certain genotype, Riboflavin effectively reduces blood pressure (R, R2).

Elderly who had oral Riboflavin supplementation had reduced homocysteine, which causes heart disease (R).

Riboflavin and folate work together to reduce homocysteine levels (R).

6) Cancer 

Riboflavin consumption (in addition to vitamin B6) reduces colorectal cancer risk in postmenopausal women (R).

B2 consumption also reduced the risk of colon cancer among women (RR).

There is little association between B2 intake and prostate cancer prevalence (R), breast cancer (R), and lung cancer (R).

7) Bone Health

B2 and other B vitamin play a protective role in bone health (R).

In a study of people withMTHFR C677T “AA” genotype, those who had the lowest intake of Riboflavin had a 1.8-2.6X increased risk of getting fractures (R).

Increased intake of Riboflavin leads to more bone mass density in the neck (R).

8) Liver Health

Riboflavin may be used as a liver-protective agent from liver toxins (R).

Riboflavin also reduces liver injury following liver ischemia and reperfusion in mice (R).

9) Autoimmune Disorders

In a case study, B2 treatment was effective in treating a progressive neurological disorder (Brown–Vialetto–Van Laere syndrome 2) (R).

In mice, B2 helped suppress a motor disability model after the autoimmune disorder, multiple sclerosis (R).

10) Nightly Leg Cramps

B2 (along with other B vitamins) helped reduce the length, pain intensity, and frequency of nocturnal leg cramps in the elderly (R).

11) Pregnancy

In mice, vitamin B2 supplementation leads to more pregnancy, increased weight of the pups, and increased hemoglobin (R).


The recommended allowance of Vitamin B2 is 1.3mg/day for men and 1.1mg/day for women (R).

Looking for a more comprehensive multivitamin? Joe’s partnered with VitaminLab to create a custom multivitamin blend for optimal health!

The daily recommended dietary allowances (RDAs) of riboflavin (Vitamin B2) are (R):

  • Infants 0-6 months, 0.3 mg
  • 7-12 months, 0.4 mg
  • children 1-3 years, 0.5 mg
  • 4-8 years, 0.6 mg
  • 9-13 years, 0.9 mg
  • men 14 years or older, 1.3 mg
  • women 14-18 years, 1 mg
  • women over 18 years, 1.1 mg
  • pregnant women, 1.4 mg; and breastfeeding women, 1.6 mg.

Vitamin B2 Deficiencies

When iron intake is low, deficiency in B2 may facilitate the development of anemia (R).

A deficiency in vitamin B2 and B6 can leave lesions on the mucous areas of skin because of defective collagen maturation (R1, R2).

Vitamin B2 is a cause of severe allergic reactions (anaphylaxis) (R).

In elderly men with diabetes mellitus, cognitive decline is associated with low intakes of B2 (R).

B2 deficiency is related to a rise in lactate (indicative of a problem in metabolism) (R).

Side Effects

Riboflavin is Likely safe when taken by mouth. In some people, it can cause the urine to turn yellow-orange in color. When taken in high amounts it may cause diarrhea and increased urine (R).

Irregular Vitamin B2 (Riboflavin) Levels?

If you have not yet tested your riboflavin levels, I recommend that you ask your doctor to do it. If you already have your blood test results and you’re not sure what to make of them, you need to check out Lab Test Analyzer. It does all the heavy lifting for you. No need to do thousands of hours of research on what to make of your various blood tests.


1 Star2 Stars3 Stars4 Stars5 Stars
(18 votes, average: 4.00 out of 5)

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.