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3+ Benefits of Saccharomyces cerevisiae Probiotics

Written by Puya Yazdi, MD | Last updated:
Jonathan Ritter
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology) | Written by Puya Yazdi, MD | Last updated:

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S. cerevisiae, also known as brewer’s or baker’s yeast, is full of nutrients and is a promising probiotic for gut health, skin health, and wound healing. Read on to learn more.

What is Saccharomyces cerevisiae?

Saccharomyces cerevisiae is the yeast commonly referred to as brewer or baker’s yeast. This microorganism has been instrumental to winemaking, baking, and brewing since ancient times.

The commercial product known as “nutritional yeast” contains the inactivated S. cerevisiae. This product is high in protein, fiber, and B vitamins, especially folate.

S. cerevisiae is a veterinary probiotic widely used in animal nutrition [1]. Although several S. cerevisiae strains have proven probiotic potential in humans, only the related S. boulardii is currently licensed for use as a human probiotic [1].

Folate Source

S. cerevisiae is a rich dietary source of folate [2].

S. cerevisiae was shown to increase the folate contents of rye flour-water mixtures [3].

Potential Benefits of S. cerevisiae

S. cerevisiae probiotic supplements have not been approved by the FDA for medical use. Supplements generally lack solid clinical research. Regulations set manufacturing standards for them but don’t guarantee that they’re safe or effective. Speak with your doctor before supplementing.

Insufficient Evidence For

The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of S. cerevisiae for any of the below-listed uses. Remember to speak with a doctor before taking S. cerevisiae probiotics, and never use them in place of something your doctor recommends or prescribes.

1) Gut Health

Oral treatment with viable or heat-killed S. cerevisiae strain prevented bacterial translocation, protected intestinal barrier integrity, and stimulated immunity in mice with intestinal obstruction [4].

S. cerevisiae strengthened epithelial barrier function in a cell study [5].

IBS

In one clinical trial, S. cerevisiae reduced abdominal pain and discomfort in subjects with irritable bowel syndrome (IBS) [6].

In another trial, however, S. cerevisiae had no beneficial effect on IBS symptoms and wellbeing. However, it seemed to have some effect in the subgroup with constipation [7].

IBD

S. cerevisiae improved symptoms in mice with acute ulcerative colitis [8].

S. cerevisiae reduced inflammation, restored barrier function, and inhibited colitis in mice [9].

2) Skin Health

S. cerevisiae extract (SCE) is used in cosmetics, where it reduces oxidative stress and improves skin conditions. It was shown to enhance skin moisture and skin microrelief in volunteers [10].

3) Wound Healing

Topical treatment with a water-insoluble glucan from S. cerevisiae enhanced venous ulcer healing in humans. In a patient who had an ulcer that would not heal for over 15 years, this treatment caused a 67.8% decrease in the area of the ulcer [11].

Animal & Cell Research (Lacking Evidence)

No clinical evidence supports the use of S. cerevisiae for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.

4) Phytate Degradation

Phytic acid (phytate) is found in many cereal grains, oilseeds, legumes, flours, and brans. It forms insoluble complexes with minerals such as iron, zinc, calcium, and magnesium, and lowers their bioavailability. Humans lack the enzymes for phytate complex degradation [2].

By degrading phytate, S. cerevisiae may improve the absorption of iron, zinc, magnesium, and phosphorus [2, 12].

5) Mycotoxin Degradation

Agricultural products, food and animal feeds can be contaminated by mycotoxins, specific toxins produced by fungi. These toxins can lead to various diseases in humans and livestock.

Studies report that S. cerevisiae fermentation can degrade mycotoxins [2].

Furthermore, S. cerevisiae also possesses the ability to bind mycotoxins. S. cerevisiae improved weight gain and reduced genotoxicity of aflatoxin in mice fed with contaminated corn [13].

6) Infections

S. cerevisiae, when administered orally, colonized the bowel of healthy volunteers and competed with resident Candida species [14].

Vaginal administration of S. cerevisiae positively influences the course of vaginal candidiasis by accelerating the clearance of Candida [15].

Treatment with S. cerevisiae decreased proinflammatory cytokines, inhibited weight loss, and increased survival rate in mice with typhoid fever (caused by Salmonella enterica Typhimurium) [16].

S. cerevisiae beta-glucan reduced microscopic lung lesions and the virus replication rate in pigs with pneumonia caused by swine influenza virus (SIV) [17].

S. cerevisiae supplementation increased antibody titers and leucocyte counts and resulted in a decline in parasitemia in Trypanosoma brucei infected rats [18].

7) Dental Health

S. cerevisiae, as monotherapy or as an adjuvant, accelerated the tissue-repair process and ameliorated periodontitis in rats [19].

8) Pregnancy

Preeclampsia is associated with an impaired antioxidant defense that results in pregnancy complications. S. cerevisiae scavenged nitric oxide radicals and decreased oxidative stress in red blood cells and alleviates stress status in blood from a preeclamptic umbilical cord [20].

9) Mucositis

Gastrointestinal mucositis is a major and serious side effect of cancer therapy. S. cerevisiae reduced oxidative stress, prevented weight loss and intestinal lesions, and maintained the integrity of the mucosal barrier in mice with mucositis [21].

Safety & Interactions

S. cerevisiae is consumed on a daily basis worldwide. Although it is generally safe, in rare cases, S. cerevisiae may cause infections [22] and allergic responses [23].

Anti-S. cerevisiae antibodies (ASCA) have been found in many autoimmune diseases in which increased intestinal permeability occurs, including type 1 diabetes, coeliac disease, Crohn’s disease, and others [24, 25, 26]. High ASCA were also found in obesity [27].

To avoid any adverse effects or unexpected interactions, talk to your doctor before starting any new probiotic supplements.

Immune Interactions

In cell and animal studies, researchers have observed that S. cerevisiae:

About the Author

Puya Yazdi

Puya Yazdi

MD
Dr. Puya Yazdi is a physician-scientist with 14+ years of experience in clinical medicine, life sciences, biotechnology, and nutraceuticals.
As a physician-scientist with expertise in genomics, biotechnology, and nutraceuticals, he has made it his mission to bring precision medicine to the bedside and help transform healthcare in the 21st century.He received his undergraduate education at the University of California at Irvine, a Medical Doctorate from the University of Southern California, and was a Resident Physician at Stanford University. He then proceeded to serve as a Clinical Fellow of The California Institute of Regenerative Medicine at The University of California at Irvine, where he conducted research of stem cells, epigenetics, and genomics. He was also a Medical Director for Cyvex Nutrition before serving as president of Systomic Health, a biotechnology consulting agency, where he served as an expert on genomics and other high-throughput technologies. His previous clients include Allergan, Caladrius Biosciences, and Omega Protein. He has a history of peer-reviewed publications, intellectual property discoveries (patents, etc.), clinical trial design, and a thorough knowledge of the regulatory landscape in biotechnology.He is leading our entire scientific and medical team in order to ensure accuracy and scientific validity of our content and products.

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