I’ve been taking Vitamin K2 for over 5 years now, and it’s one of the most stable supplements in my regimen. I really like how it makes me feel and it has a great safety profile.
Introduction to Vitamin K2
Vitamin K2, also known as the menaquinones, is involved in blood clotting, bone health, and the regulation of some cellular functions in the human body [R].
Vitamin K2 is also important for regulation of cell growth, and maintenance of the arterial wall [R].
Vitamin K2 is also known as menaquinones [R].
There’s two main type of Vitamin K2: MK-4 and MK-7 [R].
Vitamin K2 in the form of MK-7 has a much longer half-life than the synthetic K1, which means it stays in your system for longer [R].
Humans can partly convert Vitamin K1 to K2 in the body [R].
Vitamin K2 is preferred by the liver tissues and this may be produced as MK4 by the animal from K1 or may be of bacterial origin [R].
Note that there aren’t many clinical trials on K2, but nevertheless, it’s a good supplement to “Selfhack” with.
How Vitamin K2 Works
Vitamin K is a cofactor for γ-glutamylcarboxylase, which increases the rate of the carboxylation of glutamic acid to γ-carboxyglutamic acid.
The carboxylation of glutamic acid makes it possible for proteins to be able to bind with calcium, which in turn is important in blood clotting (coagulation). Calcium binding is also an integral part of bone health and strength [R].
The K2 That I Use
Benefits of Vitamin K2
1) Vitamin K2 Helps Prevent Osteoporosis and Improves Bone Health
Osteocalcin needs K2 to become fully activated and bind to calcium [R].
Vitamin K2 maintains and improves bone mineral density. In a study done on post-menopausal women, participants with a higher level of Vitamin K2 helped prevent bone fractures [R] and improve bone strength [R].
If the bone isn’t taking in the calcium, then more of it is getting stuck in your arteries, which cause them to harden.
Studies have found up to an 80% reduction in fractures in osteoporosis patients with K2 supplements [R].
Low levels of Vitamin K were linked to increased inflammation, fractures, and bone pain [R].
2) Vitamin K2 Helps Prevent Heart Disease
Drugs that block vitamin K accelerate the hardening of the arteries in mice [R].
People with the highest intake of Vitamin K2 were 52% less likely to develop calcification of the arteries and had a 57% lower risk of dying from heart disease, over a 7-10 year period [R].
In a 3 year, double-blinded randomized controlled trial, 500μg/d of K1 supplementation was associated with reduced calcification of the heart arteries [R].
3) Vitamin K2 Makes Your Teeth Stronger
As mentioned, K2 is important for osteocalcin to work fully.
If I ever floss and start to get pain in my gums, K2 takes it away pretty fast.
4) Vitamin K2 Decreases Inflammation
Vitamin K2 is also involved with inflammatory cytokines.
Poor levels of Vitamin K are associated with a high level of cytokines, which cause bone loss. However, even when patients took Vitamin K2 supplements, their cytokine concentration did not change [R].
5) Vitamin K2 May Help Autoimmune Conditions
6) Vitamin K2 Boosts Mitochondrial Function
Vitamin K2 helps transport electrons in the mitochondria, similar to ubiquinone, which helps boost mitochondrial function and create energy.
However, in mice liver cells, it wasn’t able to replace all the functions ubiquinone (R).
In a fly model of Parkinson’s, K2 was able to help by improving the mitochondria (R).
7) Vitamin K2 May Help Some Cancers
Meta-analyses failed to find any benefits regarding recurrence of liver cancer after a year of supplementation, but slight benefits in years 2 and 3 (3-year study) [R].
Vitamin K2 goes well with other treatments such as chemotherapy, where it was shown to help prevent the growth of tumors and cancerous cells [R].
Technical: Growth arrest-specific gene 6 (Gas6) is a protein that is dependent on Vitamin K. Gas6 kills cancer cells and stops cancer growth. Without Vitamin K, Gas6 would not be able to function [R].
8) Vitamin K Helps the Brain
Vitamin K2 is the principal form of vitamin K that the brain uses.
Vitamin K2 (MK-4) was found to represent greater than 98% of total vitamin K in the brain, irrespective of age [R].
Vitamin K’s effects are hypothesized as a result of “sphingolipid metabolism” [R].
Vitamin K2 (MK-4) was found to be positively correlated with sulfatides and sphingomyelin [R].
It’s not clear precisely what these do in the brain [R], but when I first took vitamin K2, it helped my brain function.
9) Vitamin K2 Lowers the Risk of Dying From All Causes
10) Vitamin K2 Lowers Insulin Resistance
A different study found insulin resistance to decline in older men, but not women [R].
11) Vitamin K2 MAY Prevent Some of the Negative Effects of Statins and Vegetable Oils
Vegetable oils, Statins and warfarin share, in part, a common mechanism to inhibit vitamin K2-dependent processes, which is interpreted to lead to increased onset of Cardiovascular Disease, Diabetes, Chronic Kidney Disease, bone fractures and even mental disorder (R).
Therefore, taking K2 can help with the side effects of these drugs and oils.
Vitamin K2 and Varicose Veins
Some hypothesize that vitamin K can help with varicose veins (R).
Based on what I’m reading, the study that people are citing doesn’t say vitamin K2 helps.
On the other hand, MGP is a strong inhibitor of vascular calcification, but only when it’s carboxylated (R).
Vitamin K2, but not K1, is needed to carboxylate MGP, which helps avoid calcification in the arteries (R).
It could be that by shunting calcium to the bones instead of arteries, it can reduce varicose veins. But given the MGP is involved in causing varicose veins, it might be a net value of zero or less.
Bottom line: I don’t see sufficient evidence that K2 will help varicose veins. You can infer based on the evidence that is available that it can make varicose veins better or worse.
Any issue that is worsened by calcification may be helped by K2. For example, kidney stones, heel spurs or even skin health, but I haven’t seen studies for these.
Increasing Vitamin K2 Naturally
K2 is generally higher in the fat of animals, especially those that are grass fed. K1 is found in plants.
Dietary intake of vitamin K2 accounts for up to 25% of total vitamin K intake [R].
Humans can partly convert vitamin K1 to K2 in the body, but the conversion process is inefficient.
Vitamin K2 is also produced by gut bacteria in the large intestine [R].
Specifically, Lactic Acid Bacteria produce K2, in the form of MK4 [R].
Here are the levels of K2 from animals in the US that aren’t grass fed. Japan has higher values for all of these foods, while the Netherlands is mixed.
- Ghee from grass fed animals
- Chicken: 13.6–31.6 micrograms/100g [R]
- Pork: 0.2–9.9 micrograms/100g [R]
- Beef: 1.1–9.3 micrograms/100g [R]
- Egg yolks: 15.5 micrograms/100g [R]
- Salami: 9 micrograms/100g [R]
- Milk: 0.8–1.0 [R]
- Cheese: 4.7–10.2 micrograms/100g [R]
- Sauer Kraut: 0.4 micrograms/100g [R]
- Natto (fermented soy beans): 939-998 micrograms/100g of MK7 [R].
Other general categories of food:
- Fermented foods [R]
- Liver and other organs [R]
- Dairy products from grass-fed animals (cheese, curds, yogurt, milk) [R] [R] [R].
Interesting fact: Small Intestinal Bacterial Overgrowth (SIBO) causes a leaky gut and an increase in vitamin K1 [R].
Vitamin K2 Deficiency Risks
When I take retinol (vitamin A), it makes me become deficient in K2.
This is because vitamin A competes with Vitamin K2 and Vitamin D3, both of which are important for bone health.
Broad-spectrum antibiotics can contribute to K2 deficiency as a result of killing bacteria that produce K2 [R].
- Liver disease [R].
- People with inflammatory bowel disease or cystic fibrosis [R].
- Babies who are exclusively breastfed [R].
Bacteria Which Produce Vitamin K2
|Lactococcus lactis subsp. lactis||Cheese, buttermilk, sour cream, cottage cheese, cream cheese, kefir||√||√||√||√√|
|Lactococcus lactis subsp. cremoris||Cheese, buttermilk, sour cream, cottage cheese, cream cheese, kefir||√||√||√√|
|Staphylococcus xylosus||Dairy, sausage||√||√√||√|
|Staphylococcus equorum||Dairy, meat||√||√√||√|
|Bacillus subtilis “natto”||Natto||√√|
Safety of Vitamin K2
There is no known toxicity associated with this vitamin [R].
Buying Vitamin K2
I currently take this vitamin K2, as it allows to take a good dosage of K2/MK4. I take about 3-5 drops, which equals about 3-5mg of K2.
My favorite K2/MK4 supplement (what I take):
My favorite K1/2 Mix:
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