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Coconut Oil, Butter and Saturated Fat Cause Fatty Liver and Insulin Resistance

“It doesn’t matter how beautiful your theory is, it doesn’t matter how smart you are. If it doesn’t agree with experiment, it’s wrong.”
― Richard P. Feynman

Saturated Fats From Palm oil Increases Fat in Liver

Figure 1

A recent study from Sweden shows that saturated fats (SFA) from palm oil, which is similar to coconut oil in saturated fat content, increases a person’s storage of fat in the liver, which markedly increases diabetes risk.

I’ve spoken about the harms of saturated fat before, but this study is a clinical trial that mimics the real world to a large degree.    What we see is a translation of mostly animal studies to well conducted human studies.

Thirty-nine young, normal-weight subjects were randomly assigned to eat large amounts of muffins made with either palm oil (high in saturated fats) or sunflower oil (high in omega-6 polyunsaturated fats) for seven weeks. MRI showed that those who ate the saturated fat from palm oil had double the amount of fat stored in their livers compared to the sunflower oil group. Interestingly, those who ate primarily omega-6 polyunsaturated plant fat (sunflower oil) had triple the gain in muscle, compared to the palm oil group.

The subjects in the study were overeating and gained on average 1.6kg  in both groups.  Overeating PUFAs caused half of that weight to be stored as fat and the other half was turned into muscle. On the other hand, overeating saturated fat lead people to 80% of those calories to be converted to fat and 20% muscle.

What we see is overeating is never a great idea, but overeating is a fact for most of the west, so it would be wise to choose what you should overeat.

It’s important to also note that the subjects in the study were eating fructose and fructose and saturated fat have an  additive effect on increasing liver fat (R).  I’ve mentioned on the blog before that I noticed this combination didn’t go well for me and the research supports this.  Realize that fructose is an almost necessary component of the modern lifestyle, though.

I would personally rather eat more fructose than saturated fat, if I had to choose one.  And this is what I do in practice.  This is because I don’t feel weak from fructose and I never was able to overdo it, as long as I didn’t consume oils with a high saturated fat content.

The study mentions that PUFA may not only be not harmful, but also beneficial in reducing liver fat.

These results vindicate my own personal experimentation or feeling very weak from coconut oil and other saturated fat oils.

I would go further and say that this study was done in people who probably adapted to a higher fat diet over the millenia, whereas those from non nordic ancestry probably have it worse.

Butter Also Causes Fatty Liver

In a different study done in 2012, they randomly assigned 67 abdominally obese subjects to a 10-wk isocaloric diet high in omega-6 PUFAs or a diet mainly from butter, without altering the macronutrient intake.  Liver fat was assessed by MRI and magnetic resonance proton (1H) spectroscopy (MRS).

The PUFA diet contained the same omega-6′s that drive the paleo world insane.

The PUFA diet lowered LDL cholesterol by decreasing a certain protein that increases LDL cholesterol (PCSK9).  The PUFA diet also lowered inflammation, as evidenced by lower TNF receptor-2.   Insulin tended to be higher during the SFA diet (not good). In the PUFA diet reduced insulin, total/HDL-cholesterol ratio, LDL cholesterol, and triglycerides compared to the SFA diet (all positive events).

The study also found that compared with SFA intake, omega-6 PUFAs reduced liver fat and modestly improve metabolic status, without weight loss.

Most important the results were that a high omega-6 PUFA intake does not cause any signs of inflammation or oxidative stress, contradicting the paleo/low carb bloggers.

This study flies in the face of some “bulletproof” fellows and company who claim that omega-6 PUFA are deadly and we should pound butter instead.

Coconut Oil is a Relatively Recent Invention: It’s Not Even Paleo

We didn’t evolve to eat oils, especially coconut oil.  Coconut oil is a recent invention, so it’s puzzling why paleo people support it.

To get the health benefits of coconut without the drawbacks, use coconut shreds like I do.  It’s very hard to go overboard when you eat the whole food.  It’s kind of like the difference between drinking fruit juice and eating whole fruit.  Fruit juices increase diabetes risk, while eating whole fruits decrease diabetes risk.

My advice: stick to the whole food, like our ancestors did.

How Different is Palm Oil From Coconut Oil?

The first study cited above discusses palm oil, but a commenter pointed out that there can be more than one palm oil.  There’s palm kernel oil and palm oil.  Palm kernel oil is almost identical in its fatty acid profile to coconut oil, while palm oil has less saturated fat than coconut oil.  Coconut oil is ~82% saturated vs palm oil which is ~51% saturated.   However, palm oil has more palmitic acid (43% vs 8%), which may be a bit different than other saturated fats.   However, there’s much more similarities than differences.

So palm kernel oil has a higher level of saturated fat but a lower level of palmitic acid compared to palm oil.  Palm oil contains oleic acid, which is probably the healthiest type of PUFA.  There’s good reasons to think that they could’ve used either one, but since the study mentions “palm oil” it probably means palm oil.

Let’s compare this to coconut oil.  It contains a whopping 91% saturated fat, beating out palm and palm kernel oils.

Let’s also look at the fatty acids in coconut oil and see the research on each one.

The most common fatty acids in coconut oil are lauric acid (52%), Myristic acid (19%) and palmitic acid (11%) (R).  All of these have been found to cause insulin resistance (Palmitic acid (R), Myristic acid (R), Lauric acid (R)).

Technical: All of the following associations are”bad.” Myristic acid was  associated with fasting insulin, 2 hour insulin and HOMA index (which measures insulin resistance). Palmitic acid was associated with 2 hour glucose and 2 hour insulin and stearic acid was associated with fasting glucose (R).

All 3 fatty acids also raise LDL cholesterol, with lauric acid raising it the most, followed by myristic and palmitic (R).

In a case controlled analysis, risk of high-grade prostate cancer was increased  by myristic acid intake (R).

Generally, the research is pretty clear that myristic acid and palmitic acid should be limited in the diet for optimal health, so I won’t speak more about this.

What about lauric acid?  I already mentioned how it can cause insulin resistance and raise LDL.  But wait, There’s more!  A study done on mice testing Lauric acid showed that it caused broad inflammatory effects.

Technical: In the study, lauric acid increased costimulatory molecules (CD40, CD80, and CD86), MHC class II, and cytokines (IL-12p70 and IL-6) in bone marrow-derived DCs, via activating TLRs (R).  See a primer on the immune system to understand this.

However, a Malaysian study found no difference in inflammatory markers with lauric, myristic of palmitic acid (R).  Whenever I read studies that are contradictory I take closer looks- so I read the full study.  I was mainly curious about the length of the study, the size and the level of saturated fat.  It turns out that it was only 3 weeks, was  small (15 subjects per a group) and had only 30% of the diet from fat.  The results then don’t surprise me, since this wasn’t a lot of fat in the diet.  Most paleo supporters advocated for anywhere from 50-80% and mostly saturated fats.  I think these people are crazy, absent a ketogenic diet.

Anyway, I emailed the author as to which he is referring to and am awaiting a reply.

See the fatty acid profiles of various fats.

Excess Fat Stored in the Liver Leads to Diabetes

When blood sugar levels rise, the pancreas releases large amounts of insulin. Insulin lowers high blood sugar levels by driving sugar from the bloodstream into the liver. However when your liver is full of fat, the fat prevents sugar from entering liver cells. The blood sugar levels remain high to make a person diabetic.

Counterpoints

The study deals with palm oil, so it might be a bit worse than coconut oil, but I think the outcome would be similar.  The fatty acid profile isn’t too different between them and my bad experience was with coconut oil.   Coconut oil may also have more/different phytochemicals than palm oil that counteract fatty liver, but the point is that we see a high level of saturated fat increases liver fat, which is the worst kind of fat in the body.

People on  high fat diets eat very little carbs, so the situation is better, but eating little carbs has its own drawbacks.

Keep in mind that if you are eating these oils but also restricting calories and exercising, these steps will counteract the effect to a very large degree and may not cause fatty liver.  However, I felt very weak doing this and I don’t recommend this approach unless it’s a last resort to lose weight.  Whenever I over-consume any saturated fat I feel weak.  Others, however, report that they feel more energy.

A commenter has pointed out that the people in the study were over-consuming calories.  But like I said in the previous paragraph, that if you restrict calories the fatty acid profile becomes less or not relevant and this study doesn’t apply to you.  However, in the real world most people eat an excess of calories.  And I’ve seen people get convinced that coconut oil is so healthy they should use it as a medicine, so they’d eat a meal and consume coconut oil after as a health food.

The point of this post is to show you that excess saturated fat even from coconut oil, a supposed superfood, can cause insulin resistance, fatty liver and inflammation and you should consume it in moderation (if at all).  As always, if your own experiments tell you otherwise, then do what works for you, no matter what any study says!  You have to listen to your own body.

Who Do I Think Should Use Coconut Oil?

I’m not dogmatic and I won’t say coconut oil is bad for everyone all of the time.  There are some cases where coconut oil is extremely useful.  The following are three scenarios which it can come in handy.

1) Candida. For one, it’s great if you have candida.  This is because it has antimicrobials that fight against candida (RR2), as well as Capric acid (R), Saturated Fat(R), Lauric acid(R), MCT (R), which all inhibit candida.  This makes it a powerful candida tool.

2) Lectin sensitivity. I also noticed that consumption of coconut oil decreased lectin sensitivity, even though it gave me other kinds of systemic inflammation that didn’t come from food.

I found a study that showed sialic acid content increased in the gut (specifically the brush border membranes) in response to coconut oil feeding [R].  This possibly decreases lectin sensitivity by providing a medium for which lectins can bind.  See the symptoms of lectin sensitivity.

3) Weight loss, as a last resort. Coconut oil decreases my appetite and therefore consumption of calories, so if you are overweight you can try it out, though be careful.  I would recommend trying a lectin avoidance diet if sensitive to lectins or a resistant starch diet if not before you try to lose weight with coconut oil. I suspect this is particularly true with lectin sensitive individuals. But use it in conjunction with limiting calories.  Don’t view it like vegetables, where you consume as much of it as you want.  It should be used to replace meals.  Pay attention to your body.

If you decide to consume coconut oil pay attention to your body and determine if it works for you.  If you can’t determine this, then use cognitive testing like Quantified Mind or Cambridge Brain Sciences.

Study From Sweden With Bolded Sections

….We investigated liver fat accumulation and body composition during overfeeding saturated (SFA) or polyunsaturated (PUFA) fat. LIPOGAIN was a double-blind, parallel-group, randomized trial. Thirty-nine young and normal-weight individuals were overfed muffins high in SFA (palm oil) or n-6 PUFA (sunflower oil) for 7 weeks. Liver fat, visceral (VAT), subcutaneous abdominal (SAT), and total adipose tissue (TAT), pancreatic fat, and lean tissue was assessed by MRI….. Both groups gained similar weight. SFA however markedly increased liver fat compared with PUFA and caused 2-fold larger increase in VAT than PUFA. Conversely, PUFA caused a nearly 3-fold larger increase in lean tissue than SFA. Increase in liver fat directly correlated with changes in plasma SFA and inversely with PUFA. Genes involved in regulating energy dissipation, insulin resistance, body composition and fat cell differentiation in SAT were differentially regulated between diets, and associated with increased PUFA in SAT. In conclusion, overeating SFA promotes hepatic and visceral fat storage whereas excess energy from PUFA may instead promote lean tissue in healthy humans.