Top 21 Science-Based Health Benefits of Progesterone (and 4 drawbacks)

Progesterone has a lot of benefits. People often have an imbalance of their progesterone and estrogen ration – with too much estrogen and not enough progesterone.



Progesterone belongs to a group of hormones called progestogens and these are involved in the menstrual cycle, embryo creation, and pregnancy of humans and other species (R).

Progesterone is produced and released by the ovaries and maintains fertility in women (R).

Progesterone and Fertility


Progesterone prepares the uterus for egg attachment and maintains pregnancy and prevents further ovulation during pregnancy.

Progesterone is required for ovulation, fertilization and production of hormonal cells of endometrial glands (R).

Progesterone levels are low during the first stage of menstrual cycle. After ovulation, it goes up and if pregnancy occurs, it will slowly rise from the ninth week of pregnancy until the 32nd week. When progesterone is not produced enough by the body, the placenta begins to produce progesterone after 12 weeks (R).

During the menstrual cycle of a woman, the egg is released from the ovary at ovulation which is approximately at day 14, and remnants of ovarium follicle form a structure called the corpus luteum. This releases progesterone and a little estradiol. If the released egg is fertilized, progesterone prepares the body for pregnancy. However, if the egg is not fertilized, the corpus luteum breaks down and decreases the production of progesterone. Then new menstrual cycle begins (R).

When the egg is fertilized, progesterone causes the growth of blood vessels around the womb and enables the glands in the womb to secrete nutrients for early embryo.  Then progesterone leads to the thickening of the uterine lining so that the fertilized egg can attach, and maintains the womb throughout the pregnancy (R).

During the early stage of pregnancy, progesterone is essential for establishing the placenta. When the placenta is established, at around week 12 of pregnancy it takes over the production of progesterone. Therefore the progesterone is also produced by placenta during the pregnancy (R).


The Role in Breasts

Progesterone affects the development of breast during puberty and thereafter as well. It stimulates the growth of maternal breast tissue.  Breasts are composed of lobules and alveoli and progesterone helps them to develop.  It stimulates the formation of the milk glands (R).

Progesterone needs estrogen to affect the breasts since estrogen induces the production of the progesterone receptors in breast tissue to prime the breasts (R).

Progesterones Role in Milk Production

When the lobuloalveolar maturation is complete in the pregnancy (at the end of the fourth month), the breasts are fully prepared for lactation (R).

Progesterone, estrogen, prolactin and other hormones work together during pregnancy to prepare the breast for lactation (R).

Prolactin (the hormone associated with human milk production (R)) induces the onset of milk secretion (R), but estrogen and progesterone suppress the prolactin receptor production in breast tissue. Upon childbirth, estrogen and progesterone levels decrease immediately. This decrease results in the milk production and the milk production by prolactin (R).

Too Little Progesterone

According to research, low levels of progesterone cause definite abnormalities (R).

Low progesterone may be due to amenorrhea (no periods), failure to ovulate or possible miscarriage  (R).

Low progesterone prevents women from getting pregnant. Progesterone causes the uterus thickening in anticipation of receiving a fertilized egg. If the uterus cannot become thick enough, implantation cannot occur (R).

Even in the pregnant, progesterone is still required to maintain the uterus. If it is at low level, the uterus may not be able to carry the fetus (R). This may result in miscarriage (R).

Low progesterone level may result in ectopic pregnancy – or pregnancy that occurs outside of uterus (R).

Low progesterone may cause irregular or absent menstrual bleeding (R).

Too Much Progesterone

If the progesterone level is higher than normal level, this may be due to pregnancy, adrenal cancer, ovarian cancer, congenital adrenal hyperplasia (R).

Congenital adrenal hyperplasia is a disorder that affects the adrenal gland by lacking an enzyme which the adrenal gland needs to make the hormones (R).

Progesterone pills, either alone or in combination with estrogen, prevent the ovulation, as well as pregnancy (R).

Some evidence show that high levels of progesterone have a role in ovarian cancer since continuous ovulation could be involved in causing ovarian cancer (R).

Progesterone in Males

Although progesterone is thought as female sex hormone, it is also produced in the adrenal cortex in both sexes and in the testes of males (R).

The amount of progesterone is less in males than in females (R).

It balances against the overactivity of testosterone and estrogen (R).

Progesterone blocks the enzyme that converts testosterone into DHT, which helps prevent hairloss (R).

If progesterone level is lower than normal in the man, some symptoms appear, such as low libido, hair loss, depression, muscle loss, weight gain etc… (R).

In some research, a higher level of progesterone receptors was found in prostate cancer cells, suggesting that progesterone has a role in this cancer (R).

Progesterone in Hormone Therapy

Hormone therapy is used to treat certain symptoms of menopause. It works by replacing the estrogen that is no longer produced by the body (R).

Studies show that using synthetic progesterone (progestin) with estrogen increases the breast cancer risk compared to estrogen alone. By contrast using natural progesterone with estrogen does not affect breast cancer risk (R).

Before the menopause years, cells from the endometrium are shed during menstruation. When the endometrium is no longer shed, cells are overgrowth in the uterus by estrogen, which can lead to cancer (R).

Progesterone decreases the risk of endometrial cancer by making endometrium thin (R).


  • Longevity8.0/10
  • Inflammation9.0/10
  • Mood9.5/10
  • Cognition8.5/10
  • Energy8.0/10


  • Great for weight loss: helps the thyroid, reduces cravings, and reduces water retention.
  • Reduces stress & anxiety.
  • Improves energy and sleep.
  • Helps PMS and Menopause.


  • May cause headache and painful/tender breasts.
  • Prevents ovulation (causing missed periods), as well as pregnancy.
  • May increase risk for heart disease, and ovarian and prostate cancers.

Progesterone: The Good

1) Progesterone Boosts Energy Levels

Low progesterone causes low glucose supply to the brain, which may make us more mentally fatigued (R).

2) Progesterone is an Anti-Inflammatory


Progesterone has anti-inflammatory actions.

Progesterone inhibits production of the inflammatory cytokine IL-1 (R) and prostaglandins (R).

Progesterone inhibits T Lymphocyte mediated processes and reduces the formation of gap junctions (leaky gut) (R).

3-4) Progesterone Helps Lower Weight and Increases Free Thyroid Hormones

Excessive estrogen stores more food as fat (R).

Low levels of progesterone causes the liver to produce more thyroid binding globulin which binds to thyroid hormone and stops fat from being used (R).

Progesterone reduces inflammation and helps deliver leptin to your brain, which reduces appetite (R).

5) Progesterone Helps Lower Sugar Cravings

An increase in the ratio of progesterone to estrogen lowers release of insulin and lowers sugar cravings (R).

6) Progesterone is a Diuretic and Reduce Blood Pressure

Blood Pressure

Progesterone makes fluid leave the body and reduces bloating and swelling (R).

Progesterone reduces high blood pressure by acting as a natural diuretic (R).

7) Progesterone Stimulates Bone Growth

Progesterone stimulates bone growth (R).

Progesterone activates osteoblasts or bone forming cells (R).

8) Progesterone Protects Against Cancer


Progesterone stops cell division and helps prevent ovarian, endometrial, and breast cancer (R).

Progesterone also helps prevent prostrate cancer (R), fibrocysts (R), uterine fibroids (R) and endometriosis (R).

9) Progesterone Boosts Libido

Having high levels of estrogen may prevent a woman from having an orgasm (R).

Once estrogen is high, progesterone can help by increasing testosterone, which is important in experiencing desire (R).

10) Progesterone Reduces Stress and Anxiety

Progesterone has a calming effect (R) and reduces stress (R).

Progesterone works by activating GABA receptors in the brain (R).

Progesterone inhibits CRH (R).

11) Progesterone Helps Sleep


Progesterone leads to better sleep (R).

12) Progesterone Improves Mood by Increasing Serotonin and Dopamine

Progesterone is the material needed to produce serotonin and dopamine (R).

13) Progesterone Helps With Common Symptoms of Menopause

Estrogens levels fall by half during menopause. Progesterone levels reach zero (R).

The high ratio between estrogen and progesterone causes the problems of menopause.

Giving people progesterone cream can help with hot flushes, mood swings, insomnia, night sweats, vaginal dryness and restlessness (R).

14) Progesterone Causes Relief From Menstration and PMS Symptoms

Causes of PMS include cyclical changes in hormones, changes in the brain, and depression.

Symptoms include anxiety, depression, joint or muscle pain, and feeling tired.

Progesterone along with other drugs called diuretics, NSAIDS, and antidepressants can help with these conditions (R).

14 days after ovulation, if there is no pregnancy, the uterus presses in and this causes bleeding.

Low progesterone causes uncontrolled menstrual bleeding, so progesterone can limit uncontrolled bleeding (R).

15) Progesterone Helps Maintain Fertility

Progesterone helps avoid early miscarriage by maintaining the fetus and stopping the surface of the uterus from being lost to menstrual bleeding (R).

16) Progesterone Improves Muscle Mass

Progesterone improves muscle mass by promoting muscle protein synthesis (R).

17) Progesterone Helps Reverse Baldness


Progesterone inhibits the enzyme 5-alpha reductase,prevents the conversion of testosterone to dihydrotestosterone (DHT) (R).

DHT is considered to be responsible for damaging hair follicles and an important factor in hair loss (R).

18) Progesterone Improves the Skin

Progesterone moisturizes the skin (R).

Progesterone increases thickness and number of collagen, which makes skin stronger (R).

19-21) Other

Progesterone raises body temperature causing one to sweat more (R), which may help ‘detoxification’ and weight loss.

Progesterone improves the integrity and function of cell membranes (R).

Progesterone increases gut flow and speeds up the movement of the food through the digestive tract (R).

Progesterone supplementation greatly reduces preterm birth in some women (R).

Progesterone: The Bad

1) Progesterone Causes Headache


Progesterone increases headache related chemicals in the brain (R).

Progesterone increases chemicals that cause blood vessels to contract (R), which can lead a vasoconstrictive headache.

Estrogen increases chemicals that cause blood vessels to expand (R).

The increase in estrogen and decrease in progesterone can cause blood vessels to dilate then contract continuously and cause headaches (R).

2) Progesterone Causes Painful/Tender Breasts

Progesterone causes painful or tender breasts (R).

The breasts contain many hormone receptors (progesterone and estrogen) and are affected by small changes in hormone balance (R).

Each month, the ducts near the nipple fill with fluid, which causes the breast to swell and a feeling of fullness (R).

This can also cause breast tenderness (R).

This often diminishes once the menstrual cycle has started (R). 

3) Synthetic Progesterone May Increase Heart Disease Risk


Synthetic Progesterone is associated with congestive heart failure (R).

4) Progesterone Causes Missed Periods

Progesterone causes mice not to ovulate or have periods (R).

Progesterone stops cells at the surface of the uterus from dividing and causes sores on the surface of the uterus (R).

This causes the uterus to bleed (R).


Progesterone blocks the action of oxytocin (R).

Progesterone on SelfDecode

Buying Progesterone

Progesterone tablets can be taken orally.

Progesterone cream taken on the skin can be 5-7 times more powerful than progesterone taken orally.

Progesterone cream can be taken through vaginal or anal routes.

Preferred progesterone cream:

Other potentially good progesterone creams:



  1. carol close

    Where is the edit button after we have posted?
    Re: Every cell in the body has progesterone receptors. Correction: Most hormones circulate in blood, coming into contact with essentially all cells. However, a given hormone usually affects only a limited number of cells, which are called target cells. A target cell responds to a hormone because it bears receptors for the hormone.
    Forgot to add:
    .Reduces prolactin, reduces high follicle stimulating hormone which is catabolic, and reduces high luteinizing hormone which raises body temp waking you.
    • Suppresses MMPs
    •Strengthens collagen, increases cell turnover. 70% of the skin is collagen and 20% of the entire body is collagen, including arteries
    •Reduces spasm and relaxes smooth muscle. Bronchi are widened and mucus regulated. (Progesterone receptors are widely present in submucosal tissue. One reason kids sometimes outgrow asthma attacks when they start to produce progesterone after puberty).
    •Reduces gall-bladder activity.[74]
    • Normalizes blood clotting and vascular tone, zinc and copper levels, cell oxygen levels, and use of fat stores for energy.
    • May affect gum health, increasing risk of gingivitis (gum inflammation) during pregnancy when progesterone levels are highest.
    • May play a role in male behavior, such as in male aggression towards infants
    RE: *Adequate progesterone keeps women’s (Replace with:When progesterone drops, then estrogen and testosterone drop, then follicle stimulating hormone and luteinizing hormone rise, then more than 20 other hormones become unbalanced, including: gonatropin releasing hormone (rises), growth hormone (lowers), corticotropin releasing hormone ( rises), cortisol (rises), insulin (lowers), glucogon (rises), prolactin (rises), thyroid (lowers), somatostatin (rises), aldosterone (rises), calcitonin (rises), renin (rises), prostaglandins (rise), thyroxine (lowers), ghrelin (rises), leptin (lowers), melatonin (lowers), epinephrine (rises), norepinephrine (rises), adrenocorticotropic hormone (rises), antidiuretic hormone aka vasopressin (lowers), thyrotropin releasing hormone (lowers), oxytocin (lowers), parathyroid (lowers), adiponectin (lowers), glucocorticoids (rise)

  2. carol close

    Progesterone benefits for both men and women
    *Suppresses excess testosterone and estrogen.

    •Inhibits 5 alpha-reductase activity. 5 alpha-reductase participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism, and prostate cancer. There are three isoenzymes of 5-alpha reductase, which vary in different tissues with age.

    •Helps balance blood glucose. Improves insulin resistance. Plays an important role in the signaling of insulin release and pancreatic function, and may affect the susceptibility to diabetes or gestational diabetes.
    •Is calming, due to it’s action on the GABA receptor sites. GABA is a calming neurotransmitter, this prevents an excessive response to stress and reduces cortisol which is catabolic breaking down tissue.
    •Brain neurotransmitter and myelinator. Progesterones are neuromodulators and are neuro-protective, neurogenic, and regulate neurotransmission and myelination. Myelin sheaths are made of progesterone. There is also evidence that the addition of progesterone can also help remyelinate damaged axons due to trauma, restoring some lost neural signal conduction
    *Produces the neurotransmitters- dopamine and serotonin. Enhances serotonin. Increases gene expression for DNA repair mechanisms in serotonin neurons, thereby rendering them less vulnerable to stress-induced DNA fragmentation.
    •Has well-described protective effects against numerous insults in a variety of cell models, animal models and in humans, including strokes, concussions, and spinal injuries.
    •The key mediator of progesterone’s beneficial effects is on the family of growth factors called neurotrophins in the central nervous system.
    •Acts as an antiinflammatory agent and regulates the immune response.
    •Increases T cells synergistically with Vitamin D. Progesterone with vitamin D promotes generation of induced regulatory T cells with increased stability.
    • Is responsible for immune function in cooperation with vitamin D which fail with lowered progesterone and lowered vitamin D causing autoimmune disorders and other diseases.
    •Improves blood pressure. Is a vasodilator, thus enhancing blood flow which allows nutrients to reach the hair follicle (a reason for baldness. Estrogen on the other hand constricts the smooth muscle found in blood vessels.)
    •Acts as an antioxidant by increasing levels of superoxide dismutase, glutathione and catalase (which catalase is deficient in gray hair).
    •Inhibits lipid peroxidation (a high level of pro-inflammatory LDLs leads to increased lipid peroxidation). Progesterone protects against lipid peroxidation.

    •Inhibits mast cells responsible for the increase in histamine.
    •Maintains and lengthens telomeres and stabilizes DNA.

    •Inhibits Tumor Necrosis Factor-alpha.
    •Appears to prevent endometrial cancer (involving the uterine lining) by regulating the effects of estrogen.
    •Causes cancer apoptosis at progesterone levels comparable to the third trimester.
    •Suppresses the stress hormones. Cortisol uses up progesterone. Higher progesterone suppresses cortisol.
    •Suppresses the mTOR pathway. “Anti-tumor effects of progesterone in human glioblastoma multiforme: Role of PI3K/Akt/mTOR signaling” (Rapamycin does the job of decreased progesterone)
    • Increases the tumor suppressor p53 to suppress cancer “Progesterone inhibits growth and induces apoptosis in breast cancer cells: inverse effects on Bcl-2 and p53.”
    •Raises epidermal growth factor-1 (EGF-1) levels, a factor often used to induce proliferation, and used to sustain cultures, of stem cells.
    •Stimulates progenitor cells and promotes stem cell growth with estrogen/testosterone. “Progesterone stimulates progenitor cells in normal human breast and breast cancer cells.” “Hormones promote stem cell growth” Using our own stem cells with progesterone being a signal molecule is how our body renews itself.
    *Adequate progesterone keeps women’s
    *Progesterone is one of the anabolic hormones which stimulate connective tissue growth- including bone, cartilage, tendon ligaments, guts, cornea, liver, lymphatic organs, heart, vessels, lungs, adipose tissue, nervous systems, meninges, spinal cord, skin.
    *Every cell in our body has progesterone receptors.
    . *Men maintain higher progesterone levels slightly longer than women, so they are sometimes able to produce sperm for reproduction to impregnate women when they are advanced in age, whereas progesterone levels drop when women are in peri-menopause beginning in the mid 30’s. When women finally become menopausal, their progesterone production virtually stops. Women are not born with a finite supply of eggs causing menopause. Plus, even after menopause you still have many eggs left. Healthy ovaries nourished with progesterone which nourish egg producing stem cells will allow stem cells to keep replacing old eggs with new eggs over time unless progesterone levels drop. Once progesterone drops, then menopause means further hormone unbalancing and de-stabilization. Once progesterone drops in both men and women, this means the quality of the house/factory to build eggs and babies- testes/ovaries/endometrium in the uterus have weakened connective tissue. Ovaries/testes which produce eggs/sperm, become weakened with reduced progesterone, then egg/sperm production slows/ceases. Research shows progesterone keeps the endometrium healthy to implant an embryo and maintain a pregnancy. Also, eating the placenta stops apoptosis of ovarian germ-line stem cells (because the placenta is rich in progesterone).

  3. carol close

    I was wrong that they use synthetic progesterones in ovarian cancer mouse models. I have been looking for proof for my statement- however, synthetic progesterones increases cervical and breast cancer and they use synthetic progesterone in mouse models for breast cancer. “The MPA mouse breast cancer model: Evidence for a role of progesterone receptors in breast cancer.”

    “Effect of medroxyprogesterone acetate (synthetic progesterone) on the response of the rat mammary gland to carcinogenesis.” /

    Another experiment shows results that demonstrate that (real) progesterone at a concentration similar to that seen during the third trimester of pregnancy exhibited a strong antiproliferative effect on at least two breast cancer cell lines. Apoptosis was induced in the progesterone receptor expressing T47-D breast cancer cells. “Progesterone inhibits growth and induces apoptosis in breast cancer cells: inverse effects on Bcl-2 and p53.”

    It is suggested that androgens and progesterone might play an etiologic role in ovarian carcinogenesis [37]. Pregnancy results in increases in maternal circulating progesterone due to production from the placenta. Among cell lines of normal human ovarian surface epithelium and ovarian cancer epithelium, low doses of progesterone were shown to stimulate cell growth in both cell lines whereas high doses resulted in cell growth inhibition [38]. In contrast, among the same cell lines exposed to estrone and 17-β estradiol, there was continued cell growth stimulation with increasing levels of hormone [38]. While it has been suggested that estrone exerts limited effect on ovarian surface epithelium cells, the link between Hormone Therapy and ovarian cancer risk suggested in these and other data suggest that estrone, and perhaps synthetic components of Hormone Therapy, might enhance neoplastic changes in ovarian epithelium. “Estrogen, Progesterone and Epithelial Ovarian Cancer.”

    Our data have identified folicle stimulating hormone, luteinizing hormone, estrone, estradiol, testosterone, DHT, and low-dose progesterone as positive growth regulators for ovarian cancer cells. Conversely, progesterone at high concentrations has been shown to be a potent antiproliferative factor for ovarian cancer cells. (Doesn’t say if they used synthetic progesterone.) “Expression of Gonadotropin Receptor and Growth Responses to Key Reproductive Hormones in Normal and Malignant Human Ovarian Surface Epithelial Cells.”

    Progesterone lowers follicle stimulating hormone and luteinizing hormone (that climb with age) back down to normal levels.

    Estrone the carcinogenic form of estradiol common in older women and men,(reference: “Age Trends in Estradiol and Estrone Levels Measured Using Liquid Chromatography Tandem Mass Spectrometry in Community-Dwelling Men of the Framingham Heart Study.” may be converted in the liver back into estradiol by a NAD conversion, In my mind, an important reason to keep NAD levels up to normalize estradiol/estrone levels with age. .

    In enzymology, an estradiol 17beta-dehydrogenase (EC is an enzyme that catalyzes the chemical reaction.

    estradiol-17beta + NAD(P)+ (rightleftharpoons) estrone + NAD(P)H + H+

    The 3 substrates of this enzyme are estradiol-17beta, NAD+, and NADP+, whereas its 4 products are estrone, NADH, NADPH, and H+.

    This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is estradiol-17beta:NAD(P)+ 17-oxidoreductase. Other names in common use include 20alpha-hydroxysteroid dehydrogenase, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

    Estrone is known to be a carcinogen for human females as well as a cause of breast tenderness or pain, nausea, headache, hypertension, and leg cramps in the context of non-endogenous exposure.

  4. carol close

    RE: Too much progesterone. Some evidence show that high levels of progesterone have a role in ovarian cancer since continuous ovulation could be involved in causing ovarian cancer (R). No, That was an unproven theory. Real progesterone is anti-carcinogenic and activates the p53 tumor suppressor gene and inhibits mTor which synthetic progesterone does not activate the p53 tumor suppressor gene or inhibit mTor, and in fact synthetic progesterones are proven to cause cancer and are often used to induce ovarian cancer in mice models. Real progesterone in levels equal to the third trimester induces apoptosis of ovarian cancer cells “Protective Effect of Progesterone during Pregnancy against Ovarian Cancer”
    RE: Progesterone in males. The amount of progesterone is less in males than in females (R). No. Adult males have levels of progesterone similar to those in women during the follicular phase of the menstrual cycle. “NIH Clinical Center (2004-08-16). “Progesterone Historical Reference Ranges”. United States National Institutes of Health. Retrieved 2008-03-12.”
    RE: Progesterone raises body temperature causing one to sweat more (R), which may help ‘detoxification’ and weight loss. No. Luteinizing hormone increases body temperature. That is why when you are trying to get pregnant, you check to see if your temperature rises so you can tell when you are ovulating and fertile with the surge of luteinizing hormone. Progesterone lowers luteinizing hormone thus lowering body temperature which is why women go on hormone replacement therapy to relieve their hot flashes. “LH, FSH and skin temperature during the menopausal hot flash.”
    RE: Progesterone causes headaches. No. Normalizing all hormone (including cholesterol, pregnenolone, progesterone, estrogen, testosterone and DEA) levels with restorative therapy using bio-identical hormones gets rid of all migraines. “Is migraine a consequence of a loss of neurohormonal and metabolic integrity? A new hypothesis.”.: and here is the mechanism behind it. “A new horizon into the pathobiology, etiology and treatment of migraine.”
    RE: Progesterone causes painful/tender breasts. No. High prolactin levels cause painful/tender breasts and progesterone lowers prolactin levels. “Serum prolactin and oestradiol levels in women with cyclical mastalgia”. and estrogen and progesterone lower prolactin…
    RE: Progesterone causes missed periods. Progesterone stops cells at the surface of the uterus from dividing and causes sores on the surface of the uterus (R). This causes the uterus to bleed (R). No. A drop in estrogen and progesterone causes your period to start.
    RE: Preferred progesterone cream- Wild Yam Progesterone Cream. No. Buy bio-identical progesterone hormone cream because your body cannot convert diosgenin from wild yams into progesterone, DHEA (dehydroepiandrosterone) or any other sex hormone, and wild yam does not naturally contain any progesterone that your body can use. The progesterone that is made from wild yam is known as pharmaceutical progesterone because it only exists after a chemical conversion process has been performed in a lab. Many manufacturing companies prefer to use synthetic diosgenin or wild yam as primary ingredients in their products, though, simply because they’re nearly half the cost of real progesterone. Real progesterone can provide many health benefits for women, but only if it’s USP progesterone, the only type that’s bio-identical to the naturally occurring progesterone in your body.

  5. Sergio Quiñones

    Thank you Joseph. My wife (37) have serious PMS and gets very depress the last week of her menstrual cycle. I have been thinking for some time that hormone therepy could do her good. It was interesting reading your text, it is consistent with what my research in this topic.

  6. Flavio

    Some studies you referenced use synthetic progesterone, that explains side effects. Synthetic progesterone does not work like natural progesterone. Perhaps you should clarify that so people don’t get confused.

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