Evidence Based
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Grapefruit Benefits (incl Weight Loss) + Side Effects

Written by Biljana Novkovic, PhD | Last updated:
Puya Yazdi
Medically reviewed by
Puya Yazdi, MD | Written by Biljana Novkovic, PhD | Last updated:

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Grapefruit Juice

Grapefruit is recognized as a superfood with many health benefits, but has it been studied scientifically? Are these perceived health benefits real? Read on to discover 5 health benefits of including grapefruit in your diet.

What is Grapefruit?

Grapefruit is a citrus hybrid known for its bitter taste. It originated as a cross between sweet orange and pomelo, probably sometime in the 17th century.

Grapefruit is used in traditional (folk), Chinese, holistic, herbal, nutritional, and Ayurvedic medicine. You can take it as whole fruit, juice, seed extract, or essential oil.

It provides a wide range of health benefits, due to the antioxidant and detoxifying properties of its many flavonoid compounds (naringenin, narirutin, naringin, hesperidin, neohesperidin, didymin, and poncirin) [1, 2].

Grapefruit has been traditionally used for a variety of health issues, including candida, cold, diabetes, high cholesterol, infection, insomnia, nervousness, and rheumatism [3]. Read on to find out which of these benefits are supported by science.

Grapefruit Components

The biologically active components of grapefruit include:

  • Flavonoids (e.g. naringenin, naringin, hesperidin)
  • Furanocoumarins (bergamottin, 6′,7′-dihydroxybergamottin -the CYP3A4 inhibitors responsible for ‘the grapefruit effect‘)
  • Nootkatone
  • Quercetin
  • Apigenin

These components are unique to grapefruit and likely related to the effects of grapefruit, unlike quercetin or apigenin, which are flavonoids present in many plants, including grapefruit [3].

Flavonoids have antioxidant properties. Antioxidants are required to prevent the damage caused by ‘free radicals’ [4, 5].

Grapefruit chemicals vary in concentration according to species, but also to handling methods [6].

Blending rather than squeezing produces higher levels of some beneficial chemicals (such as naringenin, limonene, citric acid, and bergamottin), whilst juicing and hand squeezing results in higher levels of others (ascorbic acid and dihydroxybergamottin, respectively) [6].

Other beneficial grapefruit components include [7, 3, 8]:

Grapefruit is also high in beneficial soluble fiber. It is low in both sodium and cholesterol, and very low in calories and saturated fat.

Grapefruit Health Benefits

Possibly Effective For

1) Weight Loss

Grapefruit is possibly effective for weight loss, due to yet unknown mechanisms [9].

It is low in calories, so the substitution of higher-calorie foods may be one of the ways to improve weight loss.

According to the data collected from over 12.7k people in the National Health and Nutrition Examination Survey (NHANES) 2003–2008, consuming grapefruit regularly (grapefruit juice or fresh, canned, or frozen grapefruit) was associated with lower body weight, waist circumference, and body mass index (BMI). However, the effect was seen only among women [8].

A study (RCT) of 85 obese adults showed that consuming grapefruit (whole or juiced) before each meal, suppressed appetite by causing a feeling of fullness. This is termed ‘to preload’ (with low-calorie food) before meals [10].

In another study of 91 obese people, those taking fresh grapefruit or grapefruit juice lost significantly more weight than people taking placebo. Grapefruit also helped improve Insulin resistance [11].

An initial study in 20 people found that a citrus-based polyphenolic dietary supplement (SINETROL) containing grapefruit was effective for weight loss. However, it’s impossible to tell if the effect was due to grapefruit or other citruses [12].

A meta-analysis of 3 clinical trials with a total of 250 overweight and obese participants found that grapefruit didn’t have a significant effect on weight loss, but it did improve blood pressure [13].

Mice studies show that nootkatone, found in grapefruit, activates AMPK. This significantly increases energy metabolism and prevents obesity caused by diet [14].

Grapefruit diets are not based on proper science and can be considered to be ‘fad’ at present [15, 16].

Insufficient Evidence For

2) Insulin Resistance

One study of 91 obese people showed that after 12 weeks of supplementation, both grapefruit juice and fresh grapefruit improved insulin sensitivity [9].

Rat studies suggest that grapefruit decreases high blood sugar levels [17, 18, 19].

In mice, grapefruit juice decreased blood sugar, similar to metformin [20].

In diabetic rats, grapefruit juice increased the activity of the enzyme glucokinase, which transformed glucose into glycogen in the liver and caused blood sugar levels to decrease [21].

Another possible mechanism for whole or pulped grapefruit reducing fasting blood sugar is due to its fiber content. Increasing consumption of dietary fiber can reduce fasting glucose [22].

Naringin, a grapefruit flavonoid, didn’t decrease blood sugar in rats but reduced the effects of ketoacidosis and oxidative stress. Thus, naringin supplements could alleviate the complications of diabetes [18, 9].

Note: Grapefruit may interact negatively with metformin. One study in rats showed that grapefruit juice increases metformin-induced lactic acidosis by increasing metformin uptake by liver cells [23].

3) Blood Pressure

A meta-analysis of 3 trials with 250 participants found that grapefruit significantly decreased systolic blood pressure. However, there was a low number of clinical trials and short durations of studies, which limited the conclusions that could be drawn about the effects of grapefruit on the metabolism [15].

The polyphenol flavonoids present in grapefruit may increase nitric oxide (NO) in the blood. NO widens blood vessels reducing blood pressure [24, 1, 25].

Further clinical trials evaluating the effects of grapefruit are needed.

4) Heart Disease

A study of 74 overweight adults showed that grapefruit lowered LDL-cholesterol, which, when high, increases the risk of heart disease [1].

A double-blind study of 27 people showed that grapefruit pectin decreased cholesterol levels in people at risk of heart disease [26].

In another study of 57 adults with high cholesterol, grapefruit lowered total and LDL-cholesterol and triglycerides, which are implicated in the hardening of the arteries. Red grapefruit proved to be more effective than white [27].

According to the data collected from over 12.7k people in the National Health and Nutrition Examination Survey (NHANES) 2003–2008, consuming grapefruit regularly (grapefruit juice or fresh, canned, or frozen grapefruit) was associated with higher good cholesterol (HDL). However, the effect was seen only among women [8].

A study of 85 obese adults showed an increase in good cholesterol (HDL) in groups taking grapefruit or grapefruit juice before meals. However, the difference was not statistically significant [10].

Larger, well-designed studies are needed to confirm the beneficial effect of grapefruit when it comes to heart disease.

5) Kidney Stones

A small study of 7 patients showed that drinks containing grapefruit juice increased urinary flow and increased urinary excretion of citrate. Scientists suggest that grapefruit juice could be effective as a natural alternative to potassium citrate in the management of kidney stones (nephrolithiasis) [28].

However, larger studies are needed to confirm this.

6) Boosting Immunity

There is evidence that vitamin C, beta-carotene, lycopene, and the flavonoids present in grapefruit all help boost the immune system [29].

Grapefruit can probably boost the immune system due to its high vitamin C content [30].

However, studies looking at the immune-boosting effect of grapefruit, in particular, are missing.

Animal Research (Lacking Evidence)

No clinical evidence supports the use of grapefruit for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.

Inflammation

Grapefruit decreased inflammation in obese rats with increased production of inflammatory markers [31].

Quercetin, found in grapefruit, had an anti-inflammatory effect in mice with allergic asthma [32].

Depression

Hesperidin, present in grapefruit, has antidepressant-like properties in mice. The mechanism involves nerve endings that release and are stimulated by serotonin (serotonergic) at the 5-HT1A receptors [33].

Parkinson’s

In mice, naringin causes dopamine-releasing nerve cells to produce GDNF, which improves Parkinson’s disease [34].

In mammal cells affected by nervous system diseases (e.g. Parkinson’s), naringin decreased a specific protein (EGFP-polyQ97) from clumping. This protein can initiate cell death (apoptosis) [35].

Risks and Side Effects

Grapefruit compounds are not toxic as such, only when taken in conjunction with any of a large number of popular medications (this is the so-called “grapefruit effect”) [36].

More than 50% of drugs that interact with grapefruit are used to treat heart conditions [23, 3, 37].

Side effects may include flushing (from the widening of veins), fast heart rate, or low blood pressure [23].

Interaction with Medication

Grapefruit compounds can interact with a variety of medication, making some less and others more effective. If you’re taking any drugs, discuss your grapefruit consumption with your doctor.

Read more about the effect grapefruit has on medication here.

Melanoma (Skin Cancer)

Two 25-year prospective studies of large groups of adults showed that citrus consumption may be associated with an increased risk of malignant melanoma (skin cancer). Citrus products are high in psoralen, which absorbs ultraviolet light. Animal studies and long-term use of the drugs in people have shown it may increase the risk of melanoma [38].

Breast Cancer

An observational study in 50k postmenopausal women found that grapefruit intake was associated with an increased risk of breast cancer for those who consumed one-quarter grapefruit or more per day, likely due to grapefruit increasing estrogen [39].

About the Author

Biljana Novkovic

Biljana Novkovic

PhD
Biljana received her PhD from Hokkaido University.
Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. She is passionate about releasing the most accurate science and health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. She believes that SelfHacked has the best science that is also layperson-friendly on the web.

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