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Quercetin is the “master flavonoid”, a strong antioxidant and one of the best natural antihistamines. It can powerfully stabilize mast cells and reduce inflammation. Its health benefits have been recognized since ancient times. Read to understand the latest science about quercetin, its potential benefits, and how to increase its otherwise poor bioavailability.
I personally don’t take quercetin because it has poor absorption. I’ve tried doses as high as 2000mg and didn’t notice anything.
- Natural Antihistamine
- Increases antioxidant protection against a wide range of health conditions
- Bioavailability is not good for most supplements
- May alter thyroid function
- Inhibits COMT
What is Quercetin?
Most people have heard of flavonoids, plant-based antioxidant pigments that are being touted for many amazing health benefits. Flavonoids give plants their color and belong to the class of polyphenols. Polyphenols became a hot topic recently for their benefits in preventing heart disease, caner, and other chronic diseases [R, R].
Well, quercetin can be viewed as the “master flavonoid”. It’s the most well-researched and most abundant flavonoid of all [R].
Many vegetables, fruits, nuts, honey, and medicinal herbs are rich in it. Raw capers have the highest amount of quercetin, while apples are the most common food source. In fact, quercetin makes about 75% of all flavonoids consumed through diet [R].
Ever since antiquity, people put great value on the quercetin, consuming pomegranate juice rich in it as an elixir for good health and longevity.
Quercetin is a strong antioxidant flavonoid that can scavenge free radicals and reduce tissue and DNA damage. Quercetin boosts antioxidant defense against a wide range of health conditions linked to oxidative stress. In fact, most chronic health problems in the modern world are caused by increased oxidative stress and free radicals [R, R, R].
Nowadays, Quercetin supplements are widely available and affordable. Quercetin has many benefits for those wanting to heal or optimize their health.
A PubMed search returns almost 17k studies about Quercetin. And although clinical trials are less common, over 200 have been carried out so far. So what’s so special about it?
- Neutralize free radicals and ROS, protecting tissues and organs in the whole body
- Reduce oxidative damage to fats, which reduces cholesterol and protects against artery clogging, heart disease, and neurodegenerative diseases
- Boost levels of glutathione, the master antioxidant
- Increase the blood’s overall antioxidant power
- Reduce inflammation by blocking important inflammatory substances and pathways (including COX-2 and CRP)
- Fight bacteria and viruses
- Block the release of histamine, reducing allergies and mast cell activation
Benefits of Quercetin
1) Quercetin Protects the Brain
Quercetin protects the brain from toxic substances in mice. It increased an antioxidant enzyme, superoxide dismutase (SOD) and decreased markers of oxidative stress. It also improved cognition, learning, and memory [R].
It has an epigenetic effect in mice, increasing the expression of genes that boost the function of existing brain cells and regenerate old or damaged brain cells [R].
Flavonoids, including quercetin, block inflammatory molecules linked to serious brain disorders like Alzheimer’s disease, meningitis, AIDS dementia, and stroke [R].
Quercetin reversed cognitive deficits in aged mice with Alzheimer’s disease. It also prevented disease worsening, but had the strongest beneficial effect in the early-middle stages of the disease [R].
2) Quercetin Might Heal Leaky Gut
Chronic stress can over-activate mast cells in the gut, which leads to increased inflammation and permeability of the gut lining (leaky gut). Quercetin has dual action: it helps rebuild a healthy gut barrier and prevents mast cells from flooding the gut with histamine [R, R].
In rat studies, it blocked histamine release and stabilized gut mast cells. This may help both prevent and heal leaky gut [R].
Quercetin reversed leaky gut in mice and helped rebuild the gut barrier. Once the gut lining was restored, inflammation decreased as well [R].
Quercetin tightened the junctions between gut cells in a cellular study. It increased the activity of genes that make the gut lining and reduce gut inflammation.This may help strengthen the gut barrier and prevent unwanted food particles from entering the bloodstream in the long run [R].
3) Quercetin Reduces Inflammation
Some men use quercetin to reduce prostate inflammation and enlargement. In an initial small study, it reduced symptoms of prostate inflammation in men by 75% [R].
In the next study of 30 men, quercetin (1000 mg/day) reduced prostate inflammation and pain in 67% of them after 1 month. Then 17 men also received bromelain and papain as an add-on to enhance quercetin absorption, along with palmetto and cranberry. This combination improved symptoms in over 80% of the men [R].
Quercetin can reduce the expression of inflammatory genes. It turned off pro-inflammatory genes, such as those that make TNF-alpha, in human immune cells. As a result, TNF-alpha levels dropped, preventing an inflammatory response [R].
Quercetin blocks the production of prostaglandins, key mediators in the inflammatory response. It also blocks a very important inflammatory enzyme, COX-2, similar most NSAID drugs like Advil. These are findings from cellular and animal studies [R, R+].
4) Quercetin May Be Anti-Aging
Researchers suggest that quercetin may work as a natural anti-aging supplement.
Senescence is a process during which cells lose the ability to regenerate with aging. These become “senescent” cells, they lose their function, produce inflammatory substances, and damage other cells. Senescence is thought to underlie aging [R].
Quercetin is considered a “senolytic”, a natural compound that may stop the aging process. In studies on human skin cells, it eliminated harmful, aging senescent cells [R+].
Quercetin extended the lifespan and increase stress resistance in worms. Another study confirmed that it increases the ability of worms to handle stress while increasing their average lifespan by 15% [R, R].
However, it is unclear how these cellular and worm studies translate to mammals. A recent study found that Quercetin does not extend the lifespan of animals. More research is needed [R].
5) Quercetin May Prevent Cancer
Scientists have long considered Quercetin and other flavonoids from in fruits and vegetables important in cancer prevention. People who eat more fruits and vegetables tend to have a lower risk of certain types of cancer [R].
Frequent intake of Quercetin-rich foods leads to a lower risk of developing lung cancer, according to an observational study of almost 10,000 people. The association was stronger in those under 50 years of age [R].
In fact, smokers who consume lots of antioxidant-rich phenols have enhanced protection against bladder cancer [R].
Quercetin lowers TNF-a and, which lowers the cancer risk; TNF-a encourages the growth and spreading of most tumor cells. In fact, mice with TNF-a deficiencies are resistant to skin cancer. Quercetin led to a 5-fold increase in the lifespan of mice with leukemia
Other cellular studies confirmed the anti-cancer properties of TNF-a-lowering flavonoids. Quercetin specifically [R]:
- Stops quickly-dividing cancer cells in an early phases of the cell cycle. This freezes tumor growth and initiates the mitochondria to kill the cancerous cell (via apoptosis) [R, R]
- Triggers cell death in human colon cancer cells (by blocking the NF-κB pathway) [R]
- Slows the growth and Induces the death of leukemia cells (by inhibiting Cox-2 expression and initiating apoptosis) [R, R]
- Reduces the spreading of tumors in the brain and liver in cell studies [R, R]
- Enhances the efficacy of conventional chemotherapeutic drugs, like doxorubicin in colon cancer cell studies [R].
- Quercetin killed leukemia and breast cancer cells without any harmful effects on normal, healthy cells [R].
Scientists think Quercetin may be a useful for rare cancers resistant to conventional drugs [R].
6) Quercetin Reduces the Histamine Response
Quercetin has a profound effect on histamine release. It acts to:
- Reduces the release of histamine and other inflammatory substances like leukotrienes, and prostaglandins [R].
- Epigenetically reduce inflammation in cells, which may help control the histamine response long term. Quercetin turns off the histamine receptor gene (H1R), making the body less sensitive to histamine [R].
7) Quercetin Fights Bacteria
Quercetin kills various types of bacteria, based on cellular studies. It reduced Staphylococcus infections, including antibiotic-resistant S. aureus (MRSA). Plus, Quercetin increased the susceptibility of MRSA to other antibacterial compounds [R, R, R].
Quercetin may also boost oral health. It blocked the growth of a wide range of oral bacteria in cellular studies. Quercetin may be a useful for dental cavities, gum infections, and mouth infections [R].
The antibacterial activity of Quercetin is partially due to its ability to block an important enzyme bacteria need to survive (DNA gyrase) (R).
With increased antibiotic use and the global spread of antibiotic resistance, Quercetin may be an effective and safe alternative [R].
8) Quercetin Protects Against Obesity
Quercetin (1000 mg/day) improved the metabolic profile in 78 obese women with PCOS in one clinical trial. It was used over 12 weeks and reduced an obesity marker (resistin), and well as testosterone and LH [R].
In mice, Quercetin supplementation reduced body weight by nearly 40%, reduced inflammatory cytokines increased in obesity, and boosted fat burning. It also increased anti-inflammatory defense (IL-10) [R].
In rats, it reduces obesity-triggered skeletal muscle wasting by blocking inflammatory receptors and their activity [R].
High dose Quercetin reduced blood glucose levels, improved blood lipids and reduced high blood pressure in obese rats. Quercetin enhanced the sensitivity of fat tissues to glucose (via GLUT4 translocation and AKT signaling), which causes fats to take more glucose from the blood and use it [R, R].
In cell studies, it reduced fat accumulation and inflammation from obesity [R].
Its effect on harmful genes may explain these benefits. Quercetin turned off obesity genes linked to inflammation (AMPK and MAPK pathways), which stops tissues from storing new fats and triggers the destruction of existing fat cells [R].
9) Quercetin May Prevent Diabetes
Mice fed a Quercetin-rich diet had lower blood glucose levels and HBA1c. Quercetin blocks the enzymes that degrade complex sugars in the gut after meals. As a consequence, less glucose is absorbed from foods and glucose levels don’t spike [R].
In rats with type 1 diabetes, Quercetin significantly lowered blood sugar levels [R].
Quercetin also improved insulin levels in diabetic mice and reduced the activity of liver and pancreas genes that can trigger diabetes. It may improve pancreas and liver function by preventing damage and recovering normal tissue regeneration [R].
Quercetin increases glucose uptake into fat cells by increasing the number and activity of important glucose transporters. It also sensitizes a pathway that controls insulin release in response to glucose (ERK1/2) (GLUT4) [R, R, R].
One cell study analyzed the effects of ten compounds from berries on glucose uptake. Two forms of Quercetin had the strongest effect on glucose uptake into tissues via the AMPK pathway (sugar-bound Quercetin-3- O-glycoside and the free Quercetin aglycone) (R, R1).
10) Quercetin May Help with Arthritis
In one study, people with Rheumatoid Arthritis who consumed lots of raw berries, fruits, vegetables, nuts, roots, seeds, and sprouts rich in Quercetin and other antioxidants had fewer symptoms [R].
Quercetin supplements (500 mg/day) had no effect on some inflammatory markers (CRP), but did reduce others (TNF-alpha and IL-6) in an 8-week study of 51 women. But in a later 8-week follow up study in 50 women, the same dose did greatly reduce joint stiffness, morning pain, after-activity pain and the inflammatory marker TNF-alpha [R, R].
In a cellular study, Quercetin triggered the death of inflammatory joint cells that contribute to the development of rheumatoid arthritis. In another study, it also stopped these cells from dividing and prevented neutrophil activation, which worsens the autoimmune response [R, R+].
Since conventional arthritis drugs (such as methotrexate and paclitaxel) are quite toxic for the whole body, quercetin may be a safe alternative [R].
11) Quercetin is Good For the Heart
Quercetin (730/day) lowered blood pressure in a trial of 41 people with high blood pressure after 28 days [R].
In a trial of 72 women with type 2 diabetes, Quercetin (500 mg/day) reduced systolic blood pressure after 10 weeks [R].
Lower dose quercetin (100 mg/day) from onion peel extract improved blood lipid profiles, glucose, and blood pressure in a study of 92 smokers. It reduced total and LDL cholesterol while lowering HDL, all of which are important factors for heart health [R].
12) Quercetin May Improve Circulation
Quercetin’s effects on circulation are closely tied to its heart-protective effects. By its antioxidant action, it protects and expands blood vessels. Healthy blood vessels can relax better and faster to improve blood flow.
In a clinical trial of 10 healthy men, a combination quercetin supplement (200 mg quercetin with EGCG and epicatechin) increased the nitric oxide status. Nitric oxide helps expand the blood vessels to deliver more blood to the body. It also reducing endothelin-1, which narrows blood vessels and counteracts nitric oxide [R].
In one observational study of 120 healthy people, a multivitamin supplement with quercetin increased blood quercetin levels, reduced homocysteine and GGT — all of which are important for heart health and circulation [R].
Quercetin improves the health of cells that line blood vessels and smooth muscles, which helps reduce blood pressure and keep blood vessels elastic [R].
13) Quercetin May Reduce Allergies
Lactose, eggs, peanuts, fish, wheat, shellfish, tree nuts, and soy can all trigger an immunoglobulin E (IgE) allergic responses [R].
Quercetin is a potent suppressor of IgE allergic responses and may used as an alternative remedy for IgE-mediated food allergies. It reduced allergies and balanced the immune response in several cellular and animal studies [R, R].
Mast cells are activated during an allergic response or in people with mast cell activation syndrome. Overactive mast cells promote inflammation by releasing molecules such as histamine, leukotrienes, cytokines, and other harmful products. Quercetin blocks human mast cell activation [R+].
Some people with allergic hay fever have an over-expression of the histamine H1 receptor (H1R) gene. The more this gene is expressed, the allergic symptoms become severe. Quercetin reduces the expression of this gene [R].
14) Quercetin Fights Viruses
Quercetin may reduce illness after intensive exercise. Endurance athletes are more likely to catch a cold since they frequently stretch their bodies to exhaustion. Quercetin (100 mg/day) reduced the incidence of upper respiratory infections such as the common cold in a trial of 40 trained athletes. It was given after 3 days of intense exercise over the 2-week exercise recovery period [R].
However, quercetin alone (1000 mg/day) for three weeks before, during, and for two weeks after the 160-km Western States Endurance Run didn’t lower flu incidence in another study [R].
15) Quercetin May Post-Exercise Recovery
In one trial, Quercetin (1000 mg/day) reduced inflammation in a trial of 30 cyclists following heavy training. It had a stronger effect combined with other antioxidants and anti-inflammatories: EGCG, isoquercetin, EPA, and DHA [R].
Combining several flavonoids may increase their bioavailability immune benefits.
Quercetin (1000 mg/day) reduced post-exercise inflammation and oxidative stress after 2 weeks in young untrained men [R].
16) Quercetin May Improve Athletic Endurance
Quercetin (1000 mg/day) increased endurance and reduced fatigue even without exercise training after just 7 days in a clinical trial of 12 untrained people [R].
In another trial of 10 young men, a single dose of quercetin (1000mg/day) improved muscle performance during and after resistance training [R].
17) Quercetin May Protect the Liver
Quercetin given before toxic amounts of alcohol, protected the liver of rats against oxidative stress. It neutralized harmful products of fat breakdown and increased the production of the master antioxidant Glutathione [R].
Quercetin protected the liver, limited damage and oxidative stress in rats exposed to toxins (alfatoxin) [R].
Acetaminophen can cause serious liver damage in high doses, and overdoses in humans are not rare. Quercetin can reduce liver damage from acetaminophen by neutralizing free radicals. It protected both the kidneys and liver in rats and improved mitochondria health [R].
In rats with liver damage, Quercetin improved liver health, decreased liver scarring, oxidative stress and DNA damage. It also lowered overall inflammation, which helps in liver recovery [R].
Quercetin protected against obesity-induced fatty liver disease in mice by activating the mitochondria and improving energy use in the liver [R].
18) Quercetin May Protect the Kidneys
Quercetin reduces kidney damage from toxic substance. In rats given the chemotherapy drug cisplatin, quercetin protected the kidney tissue [R].
Quercetin reduces kidney damage and restored kidney antioxidant enzymes in another rat study [R].
Quercetin injections were used in these animal studies, which good bioavailability.
19) Quercetin Might Improve Sexual Function
Oxidative stress is a primary cause of the inability to get or maintain an erection, also known as erectile dysfunction. Quercetin improved erectile dysfunction by reducing levels of oxidative stress and increasing blood-vessel-relaxing nitric oxide in diabetic mice [R].
20) Quercetin May Help with Asthma
Tightly linked to its balancing effects on Th2 dominance, Quercetin may improve allergic asthma. Quercetin relaxed smooth muscles that line the airways in a tissue study, which improves airway flow. It may provide relief of asthma symptoms and decrease the use of conventional, short-term asthma treatments if the same holds true in humans [R].
21) Quercetin May Protects Your Eyes
In rats with cataracts, Quercetin reduced eye damage and enhanced lens clarity (R).
Retinal cells found at the back of the eyes act as light receptors and play an important role in setting the color, resolution, and brightness of your vision. Quercetin had a protective effect on retinal cells and increased their survival [R, R, R].
22) Quercetin May Protect Against Radiation
In rats exposed to X-ray radiation, Quercetin reduced skin damage and prevented skin scarring [R].
23) Quercetin May Protect from Ulcers
In a trial of 40 men, quercetin applied directly to mouth ulcers relieved pain and completely healed the ulcers in half of the cases within 7–10 days [R].
Quercetin protected against stomach ulcers and acid reflux in animal studies. In cells it also blocked the growth of Helicobacter pylori, the main cause of stomach ulcers. In guinea pigs with H. pylori, high doses of quercetin reduced the infection and the inflammatory response [R+].
Quercetin lowers TNF-a, based on both clinical, animal, and human studies. High TNF-a levels are associated with the following diseases:
… and others.
TNF-a is a target of many drug therapies. Antibodies raised against TNF-a are now commercially available under prescription and are proving to be beneficial for many patients.
Since quercetin has a significant impact on TNF-a, it is likely that future will explore its benefits for a whole range of health conditions linked to increased inflammation and TNF-a.
Quercetin Dosage & Bioavailability
- The dosage in clinical trials varied between ~100-1000 mg/day. The most common dose was 500-1000 mg/day [R].
The main problem with Quercetin is its poor bioavailability. Quercetin bioavailability in typical oral supplements is ~2%.
It’s important to remember that Quercetin is available in many forms: free quercetin (the aglycone) or quercetin bound to various sugar molecules. Rutin from apples, for example, is a sugar-bound quercetin. Not all of these types of quercetin have the same bioavailability. For example, Quercetin from onion powder is better absorbed than quercetin from apple peel powder [R]
Once quercetin is ingested through food, the sugar bound forms are degraded and free quercetin is releases. Free quercetin is metabolized very quickly in the small intestine, the kidneys, the large intestine, and the liver, giving rise to numerous metabolites that are probably not active [R].
Once quercetin is in the gut, its bioavailability also depends on how well it’s modified to be made more soluble [R+].
Children and Pregnancy
A safe quercetin dose for children and pregnant women has not been established or studied.
Quercetin is likely safe if taken through a diet of quercetin-rich foods during pregnancy and childhood. Caution is advised with Quercetin supplements.
Quercetin was mostly safe during pregnancy in animal studies. However, in one study Quercetin increased leukemia risk in pregnant mice. In another study on female mice, Quercetin reduced fertility [R, R, R].
Quercetin for Dogs
Quercetin is sometimes added to commercially-available dog food. Similar to humans, dogs metabolize quercetin very quickly. Its bioavailability in dogs is also low. Unlike for humans, dogs absorb the rutin form of Quercetin found in apples better than humans [R].
Some people use Quercetin to reduce allergies in dogs. In one study, dogs fed antioxidant- and Quercetin-rich diets had better metabolism and less free radicals [R].
The human dosage could be adapted to dogs if using Quercetin supplements, although the bioavailability remains uncertain.
Based on the dog size, the dosage may need to be reduced. For example, very small dogs would need only 1/10 of a typical human dose (if the dog is 1/10 the size and weight of an average person). Talk with your vet if you’re unsure how to dose quercetin for your dog.
What Increases Quercetin Absorption?
The following may increase quercetin absorption and bioavailability:
- Quercetin combined with fats or oils. The oils stimulate bile production, which can make quercetin soluble in the gut and easier to absorb [R]
- Liposomal or nano-quercetin [R, R, R]
- Quercetin added to foods, such as cereal bars (possibly) [R]
- Quercetin from onion powder as opposed to quercetin from apple peel powder [R]
- Quercetin 3-glucose as opposed to the free quercetin (in rats) [R]
- Quercetin mixed with alcohol was estimated to be ~40% bioavailable [R+].
- Bromelain may increase the bioavailability of Quercetin. Bromelain can additionally lower inflammation and allergies [R]
Quercetin + Resveratrol and ECGC Synergy
The combination of quercetin and resveratrol, a polyphenol from grapes may have added health benefits. In rats, only the combination of both reduced fat deposits, while each resveratrol or quercetin alone did not have any effects [R].
In cells, the combination blocked colon cancer and increase cancer cell death [R].
All flavonoids act in synergy to increase antioxidant defense. Quercetin increases the bioavailability of ECGC and other antioxidant flavonoids [R+].
It also blocks a drug transporter in the gut (pgp) that helps eliminate many drugs from the body.
It’s possible that Quercetin can affect the levels of commonly used drugs that are eliminated through these pathways, although no clinical studies have confirmed this.
Rutin may also reduce the effects of warfarin, so caution is advised for people on this anticoagulant.
On the positive side, it may increase the bioavailability of ECGC and other antioxidant flavonoids [R+].
Overall, Quercetin is a safe supplement that doesn’t cause any serious side effects in typical doses [R].
The side effects mentioned below were observed in animal or cellular studies. More clinical studies would need to determine the side effects of quercetin in different formulations and doses.
Quercetin Side Effects
Quercetin Has Toxic Effects on Neurons
Quercetin was toxic to rat brain cells. Higher quercetin concentrations caused more brain cells to die [R].
It’s uncertain how cellular effects and doses could translate to humans.
Quercetin Increases Homocysteine Levels
In human liver cancer cells, quercetin significantly increased homocysteine levels [R].
The same effect has not been observed in clinical trials.
High doses of quercetin and other flavonoids acted as thyroid disruptors in animal studies. People with thyroid problems should use caution [R].
Dietary Sources of Quercetin
Quercetin is found in a large number of foods. How the food was grown and transported will impact the concentrations of Quercetin. It’s possible that organic food is higher in Quercetin. In one study, organically-grown onions were higher in Quercetin and other flavonoids [R].
Food sources of quercetin include [R]:
- Vegetables such as capers (highest concentration), onions, eggplant, celery, asparagus
- fruits, especially berries, but also apples and oranges
- Black and green tea
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Caveats and Limitations
Most of the studies mentioned here were done in animals, although some clinical trials have been carried out too. All of the listed benefits rely on quercetin being absorbed, so it’s questionable if the benefits that lack clinical trials can be applied to humans.
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