Horse chestnut trees originated from Greece and the Balkan Peninsula and are now cultivated worldwide. Horse chestnut seed extract may help with leg vein problems, swelling, and hemorrhoids. Packed with an abundance of antioxidants, horse chestnuts may protect against inflammation and cancer. Read on to learn more about the health benefits of horse chestnuts.

What is Horse Chestnut?

Horse chestnut trees (Aesculus hippocastanum) are recognized by their large, towering trunks and full branches that tout clusters of white flowers with chestnut-like seeds (also known as conkers or buckeyes). The raw seeds, barks, leaves, and flowers should not be ingested as they contain a poison called esculetin that may lead to increased risk of bleeding and DNA damage [1, 2].

Seeds from horse chestnut trees were traditionally used to reduce joint pain, soft tissue swelling, and fever as well as combat gut and bladder issues. Today, the properly processed horse chestnut seed extract holds promise for treating leg vein problems (chronic venous insufficiency), hemorrhoids, and swelling (edema) [3].

Other less common health benefits of horse chestnuts are to increase male fertility, relieve eczema, reduce menstrual pain, and heal skin sores [1].

Components of Horse Chestnut

The main active component of horse chestnut seeds is aescin, or escin (a mixture of triterpenoid saponins). Escin protects blood vessels, promotes blood circulation, and is anti-inflammatory [4, 5].

Escin shouldn’t be confused with esculetin – the poisonous ingredient in non-processed horse chestnuts [4].

Horse chestnut seed extract also contains antioxidant, cancer-fighting, and anti-inflammatory flavonoids and phenolic acids such as [6]:

Mechanism of Action

Escin in horse chestnut seeds acts by:

  • Reducing swelling by strengthening and narrowing blood vessels (via calcium channels) [3]
  • Strengthening blood vessels (increasing prostaglandin F2)
  • Reducing blood clotting and blood pressure (by reducing platelet aggregation) [7]
  • Reducing inflammation (by blocking Nitric Oxide)
  • Reducing allergies (by suppressing white blood cells) [8]
  • Fighting cancer by causing cancer cell death (apoptosis) and increasing autophagy [9]
  • Fighting cancer by decreasing cancer cell growth and spreading [10]

Health Benefits of Horse Chestnut

1) Treats Chronic Vein Problems

Leg vein problems can result in chronic venous insufficiency (CVI). Valves in veins help carry blood from the legs back to the heart. When the valves become weakened or damaged, you may experience swelling, pain, fatigue, tension, and itching in the legs.

Numerous human studies confirm the benefits of horse chestnuts for treating chronic vein problems. Horse chestnut seeds reduced the number of fluids in lower legs as well as ankle and calf swelling in people with chronic leg problems (Systematic Review of 17 studies) [11].

Compared to placebos, horse chestnut reduced leg swelling, pain, fatigue, and itching based on 21 clinical trials involving ~12,000 CVI patients (2-12 weeks, oral dosages 100-150 mg daily) [1].

2) Reduces Swelling

Edema is caused by the buildup of fluids under the skin, leading to swelling. It can affect the lower legs and feet, and symptoms include stiff joints, aching limbs, skin color changes, and weight gain [1].

In two clinical trials, 125 patients who received escin injections (5-10 mg twice a day) after surgery noticed reduced temperature and swelling 3-4 days after surgery [1].

Escin decreased the production of inflammatory compounds (suppresses neutrophil activation) and increased energy use (increases ATP) in human cells [12].

Escin also increased the contraction of veins, helping to push blood back to the heart and decrease swelling (via reducing calcium sensitivity) in rat muscle cells [13].

3) Strengthens Small Blood Vessels

Escin may strengthen small blood vessels (capillaries) that otherwise become swollen when weakened.

In a tissue study on human leg veins, escin increased the tone of veins (contracting them due to increased PGF-2) [3].

Escin also blocked enzymes that break down blood vessel walls, prevented leakage, and maintained the structure of capillaries. Daily escin (1 mg/kg) reduced breakdown of rat tissue over 3 weeks [3].

4) Improves Hemorrhoids

Hemorrhoids are also caused by swollen veins in the anus.

In a study of 80 patients with hemorrhoids, escin (40 mg) improved bleeding and swelling in over 80% of patients during two months [3].

5) Reduces Inflammation

In a human study, escin from horse chestnut (5 mg twice daily, intravenous, 2 weeks) reduced inflammation in 24 women with vein problems. It acts by blocking the release of inflammatory compounds and reducing the activation of immune cells that increase inflammation [3].

In one study, Kaempferol found in horse chestnut decreased inflammation in the breast cancer cells of mice (by reducing oxidative stress and the activity of immune cells) [14].

In dog models, the leaves of horse chestnuts have been used to reduce swelling in gum disease [15].

6) May Improve Male Fertility

In a study of 219 Chinese male patients with infertility (due to prostate vein swelling) 60 mg of escin for 2 months improved sperm quality, motility, and amount (by at least 30%) [16].

7) Has Anti-aging Effects

Clinical testing of 3% horse chestnut gel on 40 female volunteers (3 times a day, 9 weeks) diminished wrinkles around the eyes compared to the controls [17].

8) Improves Gut Health

Escin blocks the effects of serotonin, an important neurotransmitter in the gut [18].

In mice, escin increased gut flow and decreased inflammation. Gut flow in mice with paralyzed gut muscles improved with escin supplementation [19].

In a cell study, P-coumaric acid also helped beneficial gut microbiota detoxify the body [20].

9) May Reduce Blood Sugar

Escin from Japanese horse chestnut reduced blood sugar levels in mice given large amounts of sugar (glucose tolerance test). This could be important for treating both diabetes and obesity [21, 22].

10) May Protect the Kidneys in Diabetes

Diabetic complications can damage the kidneys. In diabetic rats with kidney damage, horse chestnut seed extract reduced inflammation and markers of kidney damage (blood urea nitrogen, and creatinine). Horse chestnuts were capable of restoring kidney function [23].

11) May Fight Cancer

Flavonoids and phenolic acids found in horse chestnut seeds may play a role in fighting cancer.

In a cell study, apigenin reduced human breast cancer tumor growth and spreading [24].

In pancreatic cancer cells, esculetin blocked the growth of pancreatic cancer. In a brain cell study, the flavonoids quercetin and kaempferol blocked the spreading of a brain tumor that affects children (medulloblastoma) [25, 26].

12) Is an Antioxidant

Antioxidants delay cell damage. Rat tissue studies have shown that p-coumaric acid from horse chestnut seed extract is an antioxidant [2720].

In cell studies, escin was a more powerful antioxidant than Vitamin E. The effect of escin is boosted by numerous other antioxidants in the plant [28].

13) May Fight Infections

Caffeic acid found in horse chestnut killed bacteria in a cell study [29].

14) May Protect the Skin

Horse chestnut seed extract protects cells and reduces inflammation, which is linked to anti-aging effects. These qualities, along with escin’s “gentle, soapy feel,” suggest the potential use of horse chestnuts in cosmetics [28].

Horse Chestnut in Combination with Other Compounds

In rat models, escin reduced arthritis in combination with a low dosage of prednisone (Deltasone, Rayos) [30].

In rats with colon cancer, horse chestnuts improved the activity of beneficial gut bacteria in combination with a prebiotic and flaxseed oil [31].

Side Effects & Precautions

Horse chestnut seeds need to be properly processed before use. Otherwise, the seeds contain the poison esculetin. Esculetin can cause a headache, nausea, coma, and paralysis [3].

When prepared correctly, horse chestnuts have few side effects. In some cases, the purified extract can still cause severe skin rash, dizziness, upset stomach, and headache. Horse chestnut damaged red blood cells in rabbits given a high dose for a month (about 10 times greater than the usual dose), but no other toxic effects have been recorded [4].

Limitations and Caveats

Although many studies proved the benefits of escin for leg vein problems, make sure to speak to a healthcare professional about treatment if you have a venous disease.

Other benefits of escin such as menstrual pain relief do not have studies to back them up. Long-term use has not been evaluated and is not recommended.

Due to lack of research, the use of escin in children, pregnant or breastfeeding women is not recommended.

Drug Interactions

Since horse chestnut can reduce blood clotting, it can interact with drugs that have a similar effect (ibuprofen, aspirin, naproxen, warfarin, and others) and increase the risk of bleeding [7].

Horse chestnut may lower blood glucose. In combination with antidiabetic drugs or insulin, this can raise the risk of very low sugar levels (hypoglycemia) [21].

Since horse chestnuts reduce fluids in the body, this could increase lithium levels [1].



Horse chestnut is a herbal supplement that can be purchased as a cream, capsule (dry) or liquid extract.

Today, most horse chestnut extracts are made from the seed as opposed to the leaf or bark since the seed contains the highest concentration of escin [32].


Horse chestnut dosage depends on the sought-after health benefit.

The maximum oral dose recommended for use in humans per day is 150 mg [4].

Standardized horse chestnut extracts contain around 20% of escin [1].

The studied dose for escin injections is 5-10 mg twice daily for up to 2 weeks [1].

Creams with horse chestnut contain 2% escin and are applied 3-4 times a day up to 2 months [17].

User Experiences

Some users said horse chestnut seed extract helped them with irregular fat distribution (lipedema) and reduced swelling. However, one user often had nausea and vomiting after taking the supplement.

Most users take horse chestnut with food to avoid stomach upset.

Many users mention that horse chestnuts are effective in reducing varicose veins and leg swelling. Some report leg cramping as a major side effect, as well as chest pain, and headaches.

Buy Horse Chestnut

This section contains sponsored links, which means that we may receive a small percentage of profit from your purchase, while the price remains the same to you. The proceeds from your purchase support our research and work. Thank you for your support.

About the Author

Ana Aleksic - MS (PHARMACY) - Writer at Selfhacked

Ana Aleksic, MSc (Pharmacy)

MS (Pharmacy)

Ana received her MS in Pharmacy from the University of Belgrade.

Ana has many years of experience in clinical research and health advising. She loves communicating science and empowering people to achieve their optimal health. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. She is a strong advocate of integrating scientific knowledge and holistic medicine.

Click here to subscribe


1 Star2 Stars3 Stars4 Stars5 Stars
(18 votes, average: 4.28 out of 5)

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.