L. johnsonii is a probiotic that is especially good against H. pylori infections.
What is Lactobacillus johnsonii?
Lactobacillus johnsonii is a lactic acid bacterium that resides in the human gastrointestinal tract where it aids in polysaccharide and protein digestion and also generates a variety of nutrients, including vitamins and short-chain fatty acids. L. johnsonii also plays a role in the fermentation and preservation of various food items.
Health Benefits of L. johnsonii
1) L. johnsonii Combats H. pylori
Fermented milk containing L. johnsonii co-administered with antibiotics was shown to have a favorable effect on H. pylori gastritis (R).
During the early infection stages, administration of L. johnsonii can attenuate H. pylori-induced gastritis in mice (R).
Both live and heat-killed L. johnsonii inhibit the growth of H. pylori in mice, where they also suppress gastric acid secretion (R).
2) L. johnsonii Improves Gut Microbiota
Fermented milk with L. johnsonii increased total Bifidobacteria and Lactobacilli and decreased lecithinase-positive Clostridium in women (R).
L. johnsonii intake increased the populations of C. histolyticum, Lactobacilli, and Bifidobacteria, and decreased those of F. prausnitzii in healthy volunteers (R).
3) L. johnsonii May Improve Diabetes
L. johnsonii inhibited hyperglycemia, reduced the elevation of blood glucose and glucagon levels in diabetic rats (R).
4) L. johnsonii May Lower Blood Pressure
L. johnsonii lowers blood pressure in rats (R).
5) L. johnsonii May Be Beneficial in Liver Disease
L. johnsonii protects mice with non-alcoholic fatty liver disease (NAFLD) from liver steatosis and liver cell death (R).
6) L. johnsonii Boosts Immunity
Fermented milk containing L. johnsonii suppressed infections in the elderly (R).
L. johnsonii helps recover nutritional status and systemic immune responses in aged mice (R).
L. johnsonii inhibits the growth of Helicobacter pylori, Escherichia coli, Salmonella Typhimurium, and Clostridium difficile in laboratory experiments (R).
7) L. johnsonii Improves Allergies
The addition of L. johnsonii to levocetirizine improved perennial allergic rhinitis in children (R).
8) L. johnsonii Protects the Skin
L. johnsonii significantly inhibited the development of UVA-induced skin lesions in clinical studies (R).
L. johnsonii suppresses exacerbation of dermatitis and scratching and reduces epidermal hyperplasia and infiltration of inflammatory cells in mice (R).
L. johnsonii administered in the weaning period inhibits atopic dermatitis-like lesions in mice after maturation, by modulating or accelerating the gut immune response (R).
9) L. johnsonii May be Beneficial in Urogenital Infections
L. johnsonii inhibits G. vaginalis-induced vaginosis in mice (R).
- L. johnsonii decreases IL-1β, IL-6 (R), IL-4 (R) and IL-8 (R).
- L. johnsonii increases IL-10 (R).
- L. johnsonii increases Th17 (R).
- L. johnsonii increases COX2 (R,R) and claudin (R).
- L. johnsonii decreases TNFα (R,R,R), C-reactive protein (R) and iNOS (R,R).
- L. johnsonii inhibits NF-κB (R).
- L. johnsonii decreases GPX1, GR, CAT (R), ACACA, FAS, and PPAR-γ (R).
- L. johnsonii both increases (R) and decreases (R) IFN-γ.
- L. johnsonii increases blood Hb, serum albumin (R), and blood phagocytic activity (R).
- L. johnsonii increases IgA (R) and IgG (R) and decreases IgE (R).
- L. johnsonii increases CD8(+) T cells (R).
- L. johnsonii lowers CD86 (R).
Probiotics are generally considered safe, but should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms.