L. johnsonii  is a probiotic that is especially good against H. pylori infections.

What is Lactobacillus johnsonii?

Lactobacillus johnsonii  is a lactic acid bacterium that resides in the human gastrointestinal tract where it aids in polysaccharide and protein digestion and also generates a variety of nutrients, including vitamins and short-chain fatty acids. L. johnsonii  also plays a role in the fermentation and preservation of various food items.

Health Benefits of L. johnsonii

1) L. johnsonii  Combats H. pylori

Fermented milk containing L. johnsonii  co-administered with antibiotics was shown to have a favorable effect on H. pylori gastritis (R).

L. johnsonii  inhibits H. pylori colonization in children (R,R). and in asymptomatic volunteers (R).

During the early infection stages, administration of L. johnsonii  can attenuate H. pylori-induced gastritis in mice (R).

Both live and heat-killed L. johnsonii  inhibit the growth of H. pylori in mice, where they also suppress gastric acid secretion (R).

2) L. johnsonii  Improves Gut Microbiota

Fermented milk with L. johnsonii  increased total Bifidobacteria and Lactobacilli and decreased lecithinase-positive Clostridium in women (R).

L. johnsonii  intake increased the populations of C. histolyticum, Lactobacilli, and Bifidobacteria, and decreased those of F. prausnitzii in healthy volunteers (R).

3) L. johnsonii  May Improve Diabetes

L. johnsonii  inhibited hyperglycemia, reduced the elevation of blood glucose and glucagon levels in diabetic rats (R).

L. johnsonii  delays or inhibits the onset of type 1 diabetes in diabetes-prone rats (R,R).

L. johnsonii  inhibits insulin resistance in mice (R).

4) L. johnsonii  May Lower Blood Pressure

L. johnsonii  lowers blood pressure in rats (R).

5) L. johnsonii  May Be Beneficial in Liver Disease

L. johnsonii  protects mice with non-alcoholic fatty liver disease (NAFLD) from liver steatosis and liver cell death (R).

6) L. johnsonii  Boosts Immunity

Fermented milk containing L. johnsonii  suppressed infections in the elderly (R).

L. johnsonii  helps recover nutritional status and systemic immune responses in aged mice (R).

L. johnsonii  inhibits the growth of Helicobacter pylori, Escherichia coli, Salmonella Typhimurium, and Clostridium difficile in laboratory experiments (R).

7) L. johnsonii  Improves Allergies

The addition of L. johnsonii  to levocetirizine improved perennial allergic rhinitis in children (R).

8) L. johnsonii  Protects the Skin

L. johnsonii  significantly inhibited the development of UVA-induced skin lesions in clinical studies (R).

L. johnsonii  suppresses exacerbation of dermatitis and scratching and reduces epidermal hyperplasia and infiltration of inflammatory cells in mice (R).

L. johnsonii  administered in the weaning period inhibits atopic dermatitis-like lesions in mice after maturation, by modulating or accelerating the gut immune response (R).

9) L. johnsonii  May be Beneficial in Urogenital Infections

L. johnsonii  inhibits G. vaginalis-induced vaginosis in mice (R).


  • L. johnsonii  decreases IL-1β, IL-6 (R), IL-4 (R) and IL-8 (R).
  • L. johnsonii  increases IL-10 (R).
  • L. johnsonii  increases Th17 (R).
  • L. johnsonii  increases COX2 (R,R) and claudin (R).
  • L. johnsonii  decreases TNFα (R,R,R), C-reactive protein (R) and iNOS (R,R).
  • L. johnsonii  inhibits NF-κB (R).
  • L. johnsonii  decreases GPX1, GR, CAT (R), ACACA, FAS, and PPAR-γ (R).
  • L. johnsonii  both increases (R) and decreases (R) IFN-γ.
  • L. johnsonii  increases blood Hb, serum albumin (R), and blood phagocytic activity (R).
  • L. johnsonii  increases IgA (R) and IgG (R) and decreases IgE (R).
  • L. johnsonii  increases CD8(+) T cells (R).
  • L. johnsonii  lowers CD86 (R).


Probiotics are generally considered safe, but should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms.

About the Author

Biljana Novkovic - PHD (ECOLOGICAL GENETICS) - Writer at Selfhacked

Dr. Biljana Novkovic, PhD


Biljana received her PhD from Hokkaido University.

Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. She is passionate about releasing the most accurate science & health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. She believes that SelfHacked has the best science that is also layperson-friendly on the web.

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