L. johnsonii is a probiotic that is especially good for fighting H. pylori infections. Learn about its other health benefits & safety.
What is Lactobacillus johnsonii?
Lactobacillus johnsonii is a lactic acid bacterium that resides in the human gastrointestinal tract where it aids in polysaccharide and protein digestion and also generates a variety of nutrients, including vitamins and short-chain fatty acids. L. johnsonii also plays a role in the fermentation and preservation of various food items.
Health Benefits of L. johnsonii
1) Combats H. pylori
Fermented milk containing L. johnsonii co-administered with antibiotics was shown to have a favorable effect on H. pylori gastritis .
During the early infection stages, administration of L. johnsonii can attenuate H. pylori-induced gastritis in mice .
Both live and heat-killed L. johnsonii inhibit the growth of H. pylori in mice, where they also suppress gastric acid secretion .
2) Improves Gut Microbiota
Fermented milk with L. johnsonii increased total Bifidobacteria and Lactobacilli and decreased lecithinase-positive Clostridium in women .
L. johnsonii intake increased the populations of C. histolyticum, Lactobacilli, and Bifidobacteria, and decreased those of F. prausnitzii in healthy volunteers .
3) May Improve Diabetes
4) May Lower Blood Pressure
L. johnsonii lowers blood pressure in rats .
5) May Be Beneficial in Liver Disease
L. johnsonii protects mice with non-alcoholic fatty liver disease (NAFLD) from liver steatosis and liver cell death .
6) Boosts Immunity
Fermented milk containing L. johnsonii suppressed infections in the elderly .
L. johnsonii helps recover nutritional status and systemic immune responses in aged mice .
L. johnsonii inhibits the growth of Helicobacter pylori, Escherichia coli, Salmonella Typhimurium, and Clostridium difficile in laboratory experiments .
7) Improves Allergies
The addition of L. johnsonii to levocetirizine improved perennial allergic rhinitis in children 
8) Protects the Skin
L. johnsonii significantly inhibited the development of UVA-induced skin lesions in clinical studies .
L. johnsonii suppresses exacerbation of dermatitis and scratching and reduces epidermal hyperplasia and infiltration of inflammatory cells in mice .
L. johnsonii administered in the weaning period inhibits atopic dermatitis-like lesions in mice after maturation, by modulating or accelerating the gut immune response .
9) May be Beneficial in Urogenital Infections
L. johnsonii inhibits G. vaginalis-induced vaginosis in mice .
- Decreases IL-1β, IL-6 , IL-4  and IL-8 .
- Increases IL-10 .
- Increases Th17 .
- Increases COX2 [10, 20] and claudin .
- Decreases TNFα [20, 12, 14], C-reactive protein  and iNOS [10, 20].
- Inhibits NF-κB .
- Decreases GPX1, GR, CAT , ACACA, FAS, and PPAR-γ .
- Both increases  and decreases  IFN-γ.
- Increases blood Hb, serum albumin , and blood phagocytic activity .
- Increases IgA  and IgG  and decreases IgE .
- Increases CD8(+) T cells .
- Lowers CD86 .
Probiotics are generally considered safe but should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms.
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