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5 Factors that May Decrease Insulin Resistance

Written by Puya Yazdi, MD | Last updated:
Nattha Wannissorn
Medically reviewed by
Nattha Wannissorn, PhD | Written by Puya Yazdi, MD | Last updated:

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Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

Insulin resistance

Insulin resistance disrupts the body’s ability to effectively regulate sugar levels. It is one of the symptoms of metabolic syndrome and an early stage in developing type 2 diabetes. Read on to uncover five factors that may help decrease insulin resistance.

Insulin Resistance and Poor Health


You may hear doctors say that the problem isn’t insulin, but rather insulin resistance. Insulin resistance is when the body is using more insulin than normal to keep blood sugar in balance.

Research suggests that in most “healthy” people, insulin resistance is mainly caused by two factors: overeating and lack of physical activity. Eating too much and being inactive can cause a buildup of fat in the liver and muscles, which makes these tissues less responsive to insulin [1].

Other causes of insulin resistance include stress, pregnancy, and various disorders and diseases.

Scientific Theories

Scientists think that, in insulin resistance, the brain will not get the message that insulin is trying hard to convey (that blood sugar levels are high) [2].

In line with this theory, insulin resistance is thought to promote hunger. As people eat, insulin is released. But the body senses as if it needs more food despite, bypassing insulin’s satiety hormone action. Hence why obesity has been linked to brain insulin resistance, though more human research is needed to verify this [2].

Disease Associations

The majority of studies covered in this section deal with associations only, which means that a cause-and-effect relationship hasn’t been established.

Researchers have proposed a correlation between insulin resistance and fat accumulation in the liver. In a literature review, insulin resistance was suggested to be directly correlated to non-alcoholic fatty liver disease [3, 4].

In another study, elevated blood free fatty acids (FFA) were associated with insulin resistance [5].

In diabetics, insulin resistance was shown to inhibit glycogen synthesis and uptake [6]. Also, waist and thigh circumference (predictors of insulin resistance) were negatively correlated with the percentage of type 1 muscle fibers [7].

In prediabetic subjects, insulin resistance was linked to atherogenic changes [8].

TNF-a levels were linked to the development of insulin resistance in obese patients. TNF-a was suggested to inhibit the ability of insulin to exert its effects on the insulin receptor [9].

In adults with human growth hormone (HGH) deficiency, rHGH lowered insulin sensitivity [10].

Another study suggested a correlation between insulin resistance and chronic kidney disease pathology [11].

Animal Research

Animal findings can’t be applied to humans.

The research outlined here should guide further investigational efforts. However, it should not be interpreted as supportive of any health effects in people.

When rats had their brain insulin receptors removed, they ate more, developed insulin resistance, and became obese [12].

Rats fed a high-fat diet insulin resistance occurred first in fat and liver tissue than in muscle tissue [13].

IKKB (a mediator of inflammatory cytokine Nf-kb production) has been linked to the development of insulin resistance in lab animals [14].

Scientists are investigating the following mechanisms in cells and lab animals:

  • Whether an anti-inflammatory cytokine (IL-10) can counter insulin resistance caused by an inflammatory cytokine (IL-6) in cells [15].
  • If insulin can induce the secretion of an inflammatory marker (MCP-1), which may contribute to many diseases associated with hyperinsulinemia [16].
  • Whether leptin worsens insulin sensitivity [17] by preventing insulin from stimulating glucose uptake and fat synthesis in fatty tissue [18].

These pathways have yet to be explored in humans.

Factors that May Decrease Insulin Resistance

When to See a Doctor

If you’re struggling with insulin resistance, it’s important to schedule a visit with your doctor.

He or she should diagnose, treat, and monitor any underlying conditions causing your insulin resistance.

Your doctor may also order some blood tests. HOMA-IR is one important measure of insulin resistance. It is not measured directly in the blood but is calculated from your fasting blood sugar and insulin levels.

You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for your metabolic health.

Read through and discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.

Top Tips

The best approach to decreasing insulin resistance is to change your lifestyle. The two most important steps you can take are [19, 1]:

  • Improving your nutrition: reduce the amount of overall calories in your meals, eat more fiber and less processed carbs
  • Becoming more active: get plenty of exercise and takE regular active breaks from prolonged sitting. Be persistent, but don’t overdo it!

1) Weight Loss

Weight loss in people who are overweight has been shown to improve insulin sensitivity [20].

If you have extra pounds, the single most important thing you can do is lose weight by eating less, i.e. consuming fewer calories [21, 22, 23]!

2) Exercise

According to a meta-analysis of 11 studies with 846 diabetics, exercise was effective in decreasing insulin levels and lowering insulin resistance [24].

But does the type of activity matter?

According to a study in 1229 people, leisure-time physical activity is beneficial for reducing markers of insulin resistance, while occupational and household physical activities are not. Strenuous eccentric exercises like running downhill do more harm than good [25].

3) Fiber and Resistant Starch

Whether it’s whole grains, insoluble cereal fibers, resistant starch, or soluble fibers – studies generally agree that more fiber is good for your sugar balance [26, 27, 28, 29, 30, 31].

High intake of dietary fiber (>25 g/d in women and >38 g/d in men) has been consistently associated with 20-30% reduced risk of developing type 2 diabetes [26, 30, 32].

In two studies with over 11k people in total, those with higher dietary fiber intake had lower markers of insulin resistance (HOMA-IR) [33, 34].

In another study with almost 5,5k people, those who ate more whole grains had lower insulin resistance, less inflammation, and lower chances of getting diabetes [35].

Additionally, in ten healthy people, resistant starch was able to increase insulin sensitivity [36].

4) Sleep

Get enough good-quality sleep. Studies suggest this may support insulin and blood sugar balance. In a study of 245 high school students, shorter sleep was associated with higher HOMA-IR–the main marker of insulin resistance [37].

Similarly, in 280 adolescents, poor sleep quality was related to a greater HOMA-IR [38].

5) De-stress

Take time to deal with stress in your life. Research suggests that any activity that helps you unwind and decreases your cortisol levels may have a beneficial effect on your insulin levels – whether it’s a relaxation technique, meditation, yoga, exercise, a hobby, or simply having fun.

Several studies found that relaxation techniques such as yoga and meditation may have beneficial effects on insulin resistance [39, 40, 41].

Dietary Supplements & Specific Foods/Spices

The following foods, spices, or supplements helped lower insulin resistance in limited studies:

However, proper evidence is lacking to rate their effectiveness and safety in people with insulin resistance.

Dietary supplements have not been approved by the FDA for medical use. Supplements generally lack solid clinical research. Regulations set manufacturing standards for them but don’t guarantee that they’re safe or effective.

Speak with your doctor before supplementing.


Some genetic variations have been linked with Insulin resistance [82]. Go to SelfDecode to explore your own genetic makeup.

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About the Author

Puya Yazdi

Puya Yazdi

Dr. Puya Yazdi is a physician-scientist with 14+ years of experience in clinical medicine, life sciences, biotechnology, and nutraceuticals.
As a physician-scientist with expertise in genomics, biotechnology, and nutraceuticals, he has made it his mission to bring precision medicine to the bedside and help transform healthcare in the 21st century. He received his undergraduate education at the University of California at Irvine, a Medical Doctorate from the University of Southern California, and was a Resident Physician at Stanford University. He then proceeded to serve as a Clinical Fellow of The California Institute of Regenerative Medicine at The University of California at Irvine, where he conducted research of stem cells, epigenetics, and genomics. He was also a Medical Director for Cyvex Nutrition before serving as president of Systomic Health, a biotechnology consulting agency, where he served as an expert on genomics and other high-throughput technologies. His previous clients include Allergan, Caladrius Biosciences, and Omega Protein. He has a history of peer-reviewed publications, intellectual property discoveries (patents, etc.), clinical trial design, and a thorough knowledge of the regulatory landscape in biotechnology. He is leading our entire scientific and medical team in order to ensure accuracy and scientific validity of our content and products.

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