The phenolic compounds present in olive leaves, especially oleuropein, have been suggested to have therapeutic effects for many conditions. Olive leaf extract may help with high blood pressure, diabetes, obesity, Alzheimer’s, or heart disease. It’s even claimed to prevent genetic damage and cancer growth. If you suffer from any of these conditions, find out how olive leaf extracts may help you
Olive phenols and their derivatives are associated with many therapeutic properties. The health benefits gained from these polyphenols depend on both how much is consumed and how much the body can absorb .
- Antioxidant and anti-inflammatory
- May reduce the risk of heart disease
- May lower blood sugar
- May promote bone health
- May interact with blood pressure and antidiabetic medication
- Insufficient evidence for several benefits
- Reduced expression of fat-promoting genes: PPARy, lipoprotein lipase, fatty acid-binding protein 4 
- Enhanced differentiation of osteoblast (increased production of osteoblastogenesis markers RUNXII, osterix, collagen type 1, osteocalcin, and alkaline phosphatase) 
- Increased blood vessel development (VEGF production) 
- Reduced and normalized MDA and blood glucose levels 
- Reduced left ventricular developed and systolic pressures, stroke volume, ejection fraction and cardiac output, and blood superoxide dismutase and glutathione reductase 
- Prevented increase of serum malondialdehyde, interleukin-1β, TNF-α, creatine kinase-MB, troponin I, lactate dehydrogenase, and infarct area 
- Increased production of proteins that prevent cell death (Bcl-2, Bcl-XL, Bim, and p53) 
Similarly, extra virgin olive oil reduced oxidative damage to the DNA in a small trial on 10 postmenopausal women .
As previously mentioned, the blood sugar-lowering effects of oleuropein were due to its ability to block free radical production by Nox2 in a small trial on 20 healthy people .
In an experiment with mice poisoned by arsenic, oleuropein reduced oxidative damage in blood, liver, kidney, and brain tissues .
The existing evidence suggests that olive leaf extract has antioxidant activity. You may discuss with your doctor how it may help your antioxidant status.
In another trial on 232 patients with high blood pressure, taking 500 mg of oleuropein 2x/day for 8 weeks was as effective as a diuretic (captopril, 12.5-25 mg 2x/day) at lowering both systolic and diastolic blood pressure .
The blood pressure-lowering effects of olive leaf extract are possibly due to its ability to preserve blood vessel function, as seen in a small trial on 13 people with mildly high blood pressure .
In 4 clinical trials on almost 150 people with high blood cholesterol levels, olive polyphenols (taken as virgin olive oil, olive pomace-enriched biscuits, and a dietary supplement) lowered blood fat (total cholesterol, LDL cholesterol, and triglyceride) levels [26, 27, 28].
To sum up, the evidence suggests that olive leaf extract may help prevent heart disease by lowering blood pressure and preventing artery clogging. Note, however, that it’s not approved by the FDA to treat or prevent these conditions. You may use it to improve your cardiovascular health if your doctor determines that it may help in your case.
In a small trial on 18 healthy volunteers, olive leaf extract (standardized to 51 mg oleuropein and 9 mg hydroxytyrosol) reduced the production of a pro-inflammatory cytokine (IL-8) and improved blood vessel function .
Hydroxytyrosol also reduced inflammatory pain in a small trial on 25 people with joint disease (gonarthrosis) .
In colon samples isolated from 14 people with ulcerative colitis, treatment with olive leaf extract reduced the production of pro-inflammatory molecules (the enzyme COX-2 and the cytokine IL-17) and infiltration of immune cells (CD3, CD4, and CD20), resulting in decreased inflammatory damage 
In a study of mice injected with cisplatin to induce kidney damage, oleuropein reduced inflammation and prevented kidney cell death .
In mice with skin injuries, oleuropein reduced inflammation and sped up wound healing .
All in all, limited evidence suggests that olive leaf extract and its components have some anti-inflammatory activity. Further clinical research should confirm these findings and establish how to use them therapeutically.
In another trial on 46 middle-aged overweight men (and thus, at risk of developing type 2 diabetes), supplementation with olive leaf extract for 12 weeks improved insulin sensitivity and the activity of the pancreatic cells that produce this hormone (beta-cells) .
In diabetic rabbits, oleuropein lowered and restored normal blood glucose levels and reduced a marker of oxidative damage (MDA) .
In a clinical trial on 64 women with bone loss (osteopenia), consuming olive leaf extract for 12 months maintained bone mineral density and increased the blood levels of a bone-forming cell production marker (osteocalcin) .
A study in human bone marrow stem cells found that oleuropein increased bone cell production .
In a clinical trial on 32 high-school athletes, taking olive leaf extract (equivalent to 20 g olive leaves and 100 mg oleuropein) for 9 weeks slightly reduced the number of sick days due to upper respiratory illness. However, it had no effect on the incidence of the illness .
Toxoplasmosis was inhibited by oleuropein treatment in kidney cells and in mice. Oleuropein effectively prevented cell death and tumor formation in the spleens and livers of infected mice .
No clinical evidence supports the use of olive leaf extract for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies should not be interpreted as supportive of any health benefit.
Preliminary research suggests that olive leaf extract may help fight obesity by preventing the body from generating more fat cells .
Amyloid diseases, such as Alzheimer’s, are partly caused by the buildup of misfolded proteins in tissues, which triggers inflammation and tissue damage .
Olive leaf extracts can prevent these misfolded proteins from entering the brain. This effectively reduced toxicity and tissue damage in mouse studies .
Even in the late stages of Alzheimer’s, mice experienced improved brain cell function after being treated with oleuropein aglycone .
In rats with Parkinson’s disease, olive leaf extract reduced brain cell damage and death .
Oleuropein reduced spatial memory impairment and improved cognition in rats with anesthesia-induced oxidative stress .
This list does not cover all possible side effects. Contact your doctor or pharmacist if you notice any other side effects.
Call your doctor for medical advice about side effects. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada, you may report side effects to Health Canada at 1-866-234-2345.
Olive oil and its extracts may lower blood pressure and blood sugar levels. Taking olive oil extracts in addition to medication for diabetes or high blood pressure may cause blood sugar levels or blood pressure to drop too low [57, 58, 59].
If you’re interested in natural and more targeted ways of lowering your inflammation, we at SelfHacked recommend checking out this inflammation wellness report. It gives genetic-based diet, lifestyle and supplement tips that can help reduce inflammation levels. The recommendations are personalized based on your genes.
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