Fisetin is great for reducing inflammation and all things related to brain function. There’s a variety of health-promoting and disease-preventing benefits.
What is Fisetin?
- Great for reducing inflammation
- Improves brain function and memory
- Great antioxidant
- Natural pain killer
- Increases the master antioxidant – Glutathione
- Maintains stable blood sugar
- Good for a diverse array of conditions
- It’s a relatively new supplement, and it doesn’t have a lot of research about negative effects. I personally take it, to good effect.
Health Benefits of Fisetin
Note that there are very few trials of fisetin with humans and nearly all of the studies listed here are done on animals.
1) Fisetin is Good For Your Brain
Fisetin Encourages New Brain Growth
Out of a number of studied flavanoids, fisetin was found to be the most effective at causing new brain growth .
One of the reasons fisetin possesses so many brain-boosting effects is because it is able to cross the blood-brain barrier .
Fisetin Improves Memory
Fisetin Protects Against Brain Degeneration
Fisetin has been shown to regulate a number of pathways (e.g. antioxidant & mitochondrial function) that are implicated in age-related decline in brain health .
One mechanism by which fisetin might protect against degenerative brain conditions is by activating certain transcription factors such as Nrf2 that increase the cellular levels of glutathione – a key cellular antioxidant that has protective effects on nerve cells [8, 91].
Moreover, Fisetin limits the accumulation of harmful compounds (phosphorylated tau) that accumulate in the brain and cause Alzheimer’s disease .
Fisetin is a potentially useful supplement for decreasing inflammation in microglia – immune cells that exert neurotoxic effects and are often activated in neurodegenerative conditions (see Dr. Younger speak about Microglia) .
Fisetin Decreases Brain Damage After Stroke
Another study confirmed that fisetin helps to protect whichever part of the brain is starved of blood flow during a stroke .
Ten flavonoids including fisetin were tested for their ability to protect brain cells against glutamate toxicity. Fisetin was one of four that were found to increase antioxidant defenses enough to limit toxicity .
Fisetin Minimizes Brain Damage From Injury
Traumatic epilepsy is a condition of repeated seizures after a head injury. One study showed that epileptic rats experienced less brain damage from their seizures when given fisetin – probably because Fisetin inhibits oxidative stress .
Rodents that were given a high dose of fisetin (50mg/kg of body weight) had a significantly better neurological function and reduced brain swelling after brain injury – maybe because fisetin inhibits TLR 4/NF-κB mediated inflammatory pathways .
Fisetin is Neuroprotective
Fisetin promotes nerve cell survival from trophic factor (helping molecules that allow neurons to develop and maintain connections with their neighbors) withdrawal by the enhancement of proteasomal activity .
2) Fisetin May Treat Depression
3) Fisetin Has Anti-Inflammatory Properties
Treatment with fisetin suppresses activation of mast cells, demonstrating its potential use as an anti-inflammatory .
High blood sugar in diabetics can cause inflammation of the blood vessels and lead to serious damage. These inflammatory processes are inhibited by treatment with fisetin (possibly via inhibition of the HMGB1 signaling pathway) [32, 33].
Fisetin was found to be an effective treatment for Eczema in animals as it reduced the presence of inflammatory cytokines, eosinophils, mast cells and T-cells (CD4+ & CD8+) that are typically found in atopic dermatitis skin lesions .
4) Fisetin May Prevent and Treat Cancer
The following studies are performed in animals and/or cells…Speak to your doctor if you have cancer.
Fisetin inhibits the pathways responsible for cell growth and survival that are overactive in cancer patients .
Fisetin inhibits the ability of cancer cells to invade healthy tissues .
Treatment with fisetin was able to kill acute monocytic leukemia cells by increasing levels of nitric oxide and Ca(2+) and activating pathways of apoptosis (cell death) .
Aflatoxin is one of the most potent carcinogens known to man. Fisetin was found to reverse oxidative damage in the livers of rats with aflatoxin-induced cancer .
Treatment with fisetin reduced tissue lesions and lipid peroxidation in the lungs of mice exposed to Benzo(a)Pyrene (a carcinogenic chemical) .
A diet rich in fisetin might help prevent and treat prostate cancer (by inhibiting urokinase plasminogen activator, altering genes that regulate cell cycles, and causing cancer cell death) [45, 46, 47].
Fisetin is such a promising anti-cancer agent because it appears to inhibit and kill cancers without severely affecting the surrounding normal cells – probably because it is able to identify the unique cell-signaling pathways used by cancer cells [49, 50, 51].
5) Fisetin Improves Blood Flow & Lowers Blood Pressure
Fisetin lowers the clumping together (coagulation) of blood cells in mice and, thus, lowers the chance of blockages 
By inhibiting Ca(2+) signaling, Fisetin helps reverse vasoconstriction caused by the release serotonin and phenylephrine .
Fisetin was able to reverse bad circulation in mice caused by a high-fat diet .
A rodent study found that Fisetin relaxes drug-induced contractions of blood vessels and, thus, lowers blood pressure. This action occurs regardless of blood vessel function .
6) Fisetin May Help Treat Diabetes
Diabetic mice fed a diet high in Fisetin stayed diabetic, but the kidney abnormalities normalized .
Fisetin administration normalized the increased levels of lipid content in blood, liver, and kidney in drug-induced diabetic rats .
In diabetic mice, Fisetin reduced the expected formation of cataracts .
Fisetin reduced anxiety-related behaviors in diabetic mice.
Fisetin improved mitochondrial function in diabetic rats .
Fisetin regulates carbohydrate metabolism by modulating the key regulatory enzymes in the liver and kidney tissues of diabetic rats .
7) Fisetin May Extend Lifespan
Dietary supplementation with a strawberry extract (which is said to have the highest levels of fisetin) improved the performance of rats in a rodent model of accelerated aging .
8) Fisetin May Lower Body Weight
In mice, fisetin supplementation reversed the weight gain caused by a high-fat diet .
Mice that underwent fisetin treatment had less weight increase than mice that did not undergo treatment .
9) Fisetin Lowers Pain
10) Fisetin Protects Bone
In mice with estrogen deficiency or inflammation, the consumption of fisetin resulted in less bone density loss. Bone mineral density and bone markers positively correlated with the amount of fisetin consumed .
Therefore, fisetin might be an effective tool for preventing age-related or inactivity-related (e.g. when injured) loss of bone density.
11) Fisetin Protects Skin From Sun Damage
Fisetin inhibits UVB-induced collagen degradation – a key factor in skin aging .
12) Fisetin Prevents Toxicity
As such, it might be a wise idea to take fisetin if you are taking any substance that affects the kidneys, such as pain medications, alcohol, antibiotics, and laxatives . (Speak to your doctor.)
13) Fisetin Helps Maintain Energy Levels
14) Fisetin Can Treat Infections
One study found that fisetin was antifungal and might be a useful therapeutic treatment for cryptococcosis infections .
Fisetin inhibits Listeria infection .
Fisetin inhibits arginase, a key enzyme in the Leishmania amazonensis infection and, therefore, could be used as a food supplement in Leishmaniasis treatment .
15) Fisetin is a Mast Cell Inhibitor and Can Help Histamine Intolerance
Natural Sources of Fisetin
As shown in the picture above, you can find small amounts of fisetin in many fruits and vegetables, with the highest natural source being strawberries. However, to get a truly therapeutic dose I recommend supplementation.