Disclaimer: By writing this post, we are not recommending this drug. Some of our readers who were already taking the drug requested that we commission a post on potential benefits, and we are simply providing information that is available in the clinical and scientific literature regarding its potential benefits.
What is Nicotine?
Nicotine, a potent nootropic, is a naturally occurring liquid alkaloid found in many plants of the nightshade family.
Tomatoes, potatoes, eggplant, and tobacco all contain nicotine; although, for humans, tobacco is the only plant containing significant enough quantities to have an effect.
Nicotine has recently been under the scope of research examining its beneficial role in ADHD, anxiety disorders, depression, Alzheimer’s, Parkinson’s, dementia, and even cognitive performance in the general population.
**This post is not suggesting to take up smoking or using tobacco as a means for nicotine consumption.
Nicotine Mechanism of Action
Nicotine is a monoamine oxidase inhibitor (MAOI) .
MAOIs prevent the breakdown of neurotransmitters like dopamine, serotonin, and norepinephrine in the brain, effectively increasing their levels.
Nicotine mimics the effects of acetylcholine in the brain. Acetylcholine is an excitatory neurotransmitter capable of carrying out electrical impulses, making it possible for nerves to communicate.
Nicotine acts upon a series of subsets of the nicotinic transmitters, specifically alpha-4, beta-2, and alpha-7.
It is through these receptors that nicotine is able to act upon the brain and parasympathetic nervous system (rest and digest part).
Through the alpha-7 receptor specifically, nicotine is able to influence 55 genes.
Nicotine increases blood flow in the thalamus, occipital cortex, and cerebellum .
Benefits of Nicotene
Contrary to common opinion, nicotine is not a carcinogenic substance, but it may be a ‘tumor promoter’ for some kinds of tumors .
Nicotine stimulates the growth of new blood vessels and increases the number of red blood cells .
Growing new blood vessels can help your health and brain function, but it can also promote tumors, even if it doesn’t cause cancer itself. Therefore, when it comes to cancer, nicotine is somewhat like IGF-1.
1-4) Increases Wakefulness, Motivation, Alertness, and Creativity
Nicotine also increases wakefulness, mood, and motivation via activating orexin.
Nicotine increases activity across both hemispheres of the brain, also known as bilateral neocortical activation (this is a good thing) .
Nicotine improves brain activity in users by enhancing activation in areas associated with visual attention, arousal, and motor activation .
Nicotine increases activity in the following regions of the brain: parietal cortex, thalamus, caudate, and occipital cortex .
5-7) Improves Attention, Memory, and Fine Motor Skills
Nicotine has been proven to benefit the brain in the following areas :
- Fine Motor Skills
- Alerting attention – accuracy and response time
- Orienting attention – accuracy and response time
- Short-term memory – accuracy
- Long-term memory – accuracy
- Working memory – accuracy and response time
Nicotine helps to consolidate learned information in the brain .
It improves immediate and long-term memory in human and animal models .
Nicotine improves multitasking ability by enhancing executive function, through its modulation of multiple brain networks and transmitter systems .
8) Can Help with ADHD
Nicotine can significantly reduce the severity of clinical symptoms in patients with ADHD .
Nicotine has been shown to increase vigor, quicken reaction time, increase attention and accuracy in non-smoking ADHD patients .
Nicotine caused a significant decrease in self-reported depression in ADHD .
A nicotine patch may be helpful for ADHD patients with anxiety and depression who are going through withdrawal and wanting to stay tobacco-free .
There are several mechanisms through which nicotine is neuroprotective:
- Through estrogen blocking (“anti-estrogenic effects”).
- Reducing inflammation (regulates prostaglandin production: prostanoids promote or restrain acute inflammation).
- Stimulation of nicotinic cholinergic receptors in the brain .
10-11) Preventative and a Treatment for Alzheimer’s and Parkinson’s
Nicotine has the potential in treating patients with Alzheimer’s .
When taking nicotine, Parkinson’s patients show an increased processing speed of more complex tasks .
Animal research models showed nicotine protected against brain damage in dopaminergic pathways typically associated with Parkinson’s .
Nicotine, acting on Nicotinic receptors has a beneficial influence on the brain which plays a role in the development of movement and degenerative disorders such as Alzheimer’s, Parkinson’s, and Tourette’s [17, 26, 27, 24].
Nicotinic receptor activators are being explored for the treatment of rheumatoid arthritis .
Bacterial lipopolysaccharides (LPS) decrease nicotinic receptors (α7 nAChRs) in the mouse brain, exacerbating chronic inflammation, beta-amyloid accumulation and episodic memory decline, which mimics the early stages of Alzheimer’s .
This is perhaps why people who get infections (like CIRS people) often suffer from symptoms that resemble low levels of acetylcholine.
13) May Reduce Pain
In one small study of women conducted after gynecological surgery, those given access to morphine + nicotine scored their pain at much lower levels than women who were given morphine + placebo .
14) Helps the Gut
Smoking decreased susceptibility to Crohn’s disease, ulcerative colitis, and other inflammatory bowel diseases. Clinical evidence suggests that nicotine is responsible for this difference .
Nicotine is protective in ulcerative colitis by reducing inflammation in the gut barrier, which is a hallmark of inflammatory bowel disease .
The use of Nicotine patches for 4-6 weeks resulted in clinical improvement in ulcerative colitis .
Nicotine enhances the protection of the intestinal mucosa by increasing the thickness of mucus in the colon .
Another study showed that Nicotine can slow the transit time from ingesting food to bowel movements . But my experience is that it makes me go to the bathroom.
Another study mentions that nicotine delays the emptying of contents in the stomach .
An increase in nicotine blood levels is directly related to a decrease in blood flow in the rectum (this can be a good thing) .
15-16) Helps in Weight and Insulin Control
Through anti-inflammatory pathways, nicotine indirectly decreases obesity by reducing chronic low-grade inflammation – a key feature of obesity .
17) Helps Repair Tissue
This can be done with a nicotine patch.
Nicotine stimulates the systems in the body that increases the growth of tissues and blood vessel capillaries (vasculogenesis and angiogenesis) .
In some cases, nicotine is able to repair damage to blood vessels and increase blood circulation, speeding up healing .
18) Can Help with Schizophrenia
Nicotine can improve cognitive related symptoms in those suffering from schizophrenia .
If you are schizophrenic, you will be more likely to smoke than not. 80% of schizophrenics smoke compared to 25% of the general population .
Schizophrenics may be more genetically predisposed to the beneficial effects of nicotine on the brain, and it has been suggested that smoking in schizophrenia may be a form of self-medication in an attempt to treat the underlying disease [51, 3, 38].
Nicotine gum was found to enhance the efficacy of Tourette’s treatment drugs by reducing involuntary-movement symptoms of Tourette’s syndrome .
Nicotine patches were superior to placebo in reducing behavioral symptoms of Tourette’s syndrome when used in combination with treatment drug haloperidol .
Administration of 2 mg nicotine gum or 7 mg nicotine patches enhances the therapeutic properties of neuroleptic drugs .
This effect of reducing behavioral symptoms continues even after the drug doses are halved, and the nicotine patch had been discontinued .
Nicotine patches improve attention and behavior in children and adolescents with Tourette’s syndrome .
20-28) Other Interesting Information About Nicotine
Those who take in nicotine tend to have a lower incidence of:
- Uterine fibroids 
- Canker sores 
- Endometriosis and endometriosis cancer  – nicotinic activators are being explored to treat endometriosis 
- High blood pressure
- Vomiting during pregnancy 
- Venous thrombosis (probably not causal) 
- Fatality in heart attacks (probably not causal) 
Chronic nicotine treatment enhances the relaxation of blood vessels in rats (via activation of the PKG pathway) .
The Negatives of Nicotene
There are some potential downsides to nicotine.
If you don’t do it in moderation, it can become a problem.
- First, it should only be used if your brain has fully developed.
- Second, if you have or had cancer, it might not be smart to use nicotine.
- Third, if you have an H. pylori infection, you shouldn’t use nicotine until you get rid of it.
1) It’s Addictive, and Quitting is Difficult
Trying to quit a nicotine (more specifically tobacco/smoking) habit may cause strong cravings for the substance, increased appetite, sleep disturbances, gastrointestinal problems, anxiety, anger, frustration, depression, irritability, and restlessness.
Nicotine is not a sedative or a relaxant. Studies have shown that the “sedative” or “calming” effect from cigarettes is only due to relieving the symptoms of withdrawal .
While short-term use of nicotine can have anti-anxiety and anti-depressant effects, chronic use can actually result in increased anxiety and depression following withdrawal .
2) Can Increase Tumor Growth
Nicotine is a very strong promoter of increased capillary blood vessel growth.
This new growth is usually considered a good thing except in the case of tumors, where nicotine has been shown to increase tumor growth in colon, pancreas, breast, larynx, and lung cancers [49, 63, 64, 65, 66].
Nicotine increases the progression and growth of tumors initiated by tobacco carcinogens.
Mice treated with nicotine had a nearly 40% higher tumor recurrence after initial tumors were successfully removed .
3) Adolescents Should Steer Clear of Nicotine
Nicotine ingestion shows impairment in the prefrontal cortex in adolescent users 
Cigarette smoking and/or nicotine ingestion could impair the development of the prefrontal cortex region of the brain in users under the age of 25 .
Nicotine use during adolescence actually increases the risk of cognitive impairment later in life .
Adolescent nicotine use has also been associated with a later risk of developing mental and behavioral problems such as depression, agoraphobia, panic disorder, and antisocial personality disorder .
4) Increases Risk of H.Pylori
Notes of Use of Nicotine
Dosing of Nicotine
Nicotine is a supplement whose dosage is typically self-determined by the individual to reach their desired effect. Self-dosage typically ranges from 0.2-8.0 mg. A middle range is considered to be between 1-4 mg.
Cigarettes contain roughly 10-20 mg of nicotine with the smoker taking in 1-2 mg of vaporized nicotine per cigarette. Most gums and chews contain 2 mg per piece. It is recommended to limit intake to 24 pieces in a day. I personally use 1 piece of gum on most days.
Only 10-20% of the nicotine present in a pinch of Swedish snus is absorbed via the mucous membrane and reaches the systemic circulation.
This means that only 1-2 mg of nicotine in snus is absorbed into the blood from a one gram pinch of snus containing 10 mg of nicotine .
Chewing tobacco varies widely depending upon the brand and type, containing free nicotine in amounts anywhere from 0.5 to 6 mg per dose .
Nicotine patches come in a selection of higher doses ranging from 5-21 mg, where the nicotine is released over a longer period of time.
Symptoms of Overdose
Nicotine poisoning delivers a biphasic effect – it first acts as a stimulant in the body but rapidly turns into a depressant. Vomiting is the most common symptom of nicotine poisoning and can begin as quickly as 15 minutes after ingestion .
Nicotine may also cause seizures and involuntary muscle twitching, as well as abnormal heart rhythms, a slow heart rate and fluctuating blood pressure .
In high concentrations, nicotine can cause heart failure, muscle paralysis and a buildup of fluid in the lungs’ air passages .
Nicotine is lethal if ingested in high enough doses.
An oral dose of 50 to 60 mg of nicotine is enough to kill a 160 lb person .
Nicotine overdose can cause death in as little as an hour .
Nicotine overdose causes the same response in the body as toxic exposure to organophosphate insecticides and nerve agents such as DDT or Sarin gas .
Nicotine behaves the same way in the brain as acetylcholine. In excessive amounts, it will overload synapses and disrupt nerve impulses. Over-stimulation of neurons can cause the destruction of brain tissues .
Buying Nicotine Gum
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