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Follicle Stimulating Hormone (FSH) is a hormone that is vital for reproduction and puberty. Read more below to learn about its functions.

Introduction

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Follicle Stimulating Hormone (FSH) is a gonadotropic hormone secreted by the pituitary gland. FSH is important for development during puberty as well as the function of the reproductive organs (R).

FSH Function In Men

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In men, FSH acts on the testes to stimulate sperm production (spermatogenesis). FSH stimulates testicular growth and aids the production of an androgen binding protein (R).

This androgen binding protein is crucial for the development of normal spermatogenesis and for maintaining maturing sperm cells (R).

The production of FSH is regulated by the circulating levels of testosterone and inhibin, both of which are produced in the testicles. If testosterone levels are high, FSH secretion decreases; if testosterone levels are low, FSH secretion increases (R).

Too Much FSH

Raised levels of FSH is a sign of malfunction in the testes. If the testes don’t produce enough testosterone, FSH production rises (R).

Too Little FSH

FSH is essential to normal sperm production. In the absence of FSH, puberty may not occur and infertility due to lack of sperm or low sperm quality may occur. Low FSH levels can cause delayed puberty and limited sperm production, but you can still be fertile (R).

FSH Function In Women

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In Women, FSH is essential to the pubertal development and the proper function of the ovaries. FSH regulates the secretion of estrogen (R).

When hormone levels fall towards the end of the menstrual cycle, the pituitary gland is stimulated to produce more FSH. This increase in FSH makes the ovary produce more oestradiol and inhibin (R).

This increase in these two hormones, in turn, is sensed by the pituitary gland and less FSH will be released. FSH secretion rises in the first half of menstruation and decreases after ovulation. At the very end of the menstrual cycle, FSH starts to rise and the cycle begins again (R).

Too Much FSH

Just like with men, too much FSH is a sign that something is wrong. If the ovary fails to produce enough estrogen, FSH production rises. However, FSH levels rise naturally in women around the menopausal period (R).

Too Little FSH

A dearth of FSH can lead to a lack of development at puberty and ovarian malfunction. In women, FSH deficiency leads to infertility just like in men (R).

FSH Testing

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An FSH test measures the amount of FSH in a blood sample. An FSH test is usually taken to determine why a couple can’t conceive a child (R).

A reading on FSH levels can reveal whether the ovaries or testes are functioning properly. An FSH test can be administered to check and evaluate for a low sperm count or egg supply (R).

This test can also be used to determine why a child is going through puberty early or late (or not at all). An FSH test can also help evaluate menstrual problems (R).

Follitropin Alfa

Follitropin alfa is a hormone identical to FSH. It is used as a fertility medicine to help develop eggs in the ovaries. It is also used as a fertility medicine to help men with low sperm counts produce more sperm (R).

Although it is generally safe, Follitropin alfa can cause headaches, nausea, and skin irritation (R).

Follitropin alfa is a hormone identical to FSH. It is used as a fertility medicine to help develop eggs in the ovaries. It is also used as a fertility medicine to help men with low sperm counts produce more sperm (R).

Although it is generally safe, Follitropin alfa can cause headaches, nausea, and skin irritation (R).

Technical

  • The amino acid sequence 48QKTCT52 of theβ -subunit appears to be essential for the formation of the FSH heterodimer (R).
  • Hormones with deglycosylated α-subunit are antagonists of the action of intact hormones. Oligosaccharides on the α-subunit are required for signal transduction, in particular, α52 , intracellular stability, and association with the β-subunit (R).
  • In the first, results from a meta-analysis of 12 randomized controlled trials (RCTs), with a total of 2937 participants have shown an overall live birth rate of 21.8% in the rFSH group compared to 24.9% in the uHMG group (R)

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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1 COMMENT

  • Alexandria Martinez

    My friends were talking about Follicle Stimulating Hormone at a brunch the other day. Everyone seemed to know a lot about the treatment and I was a little lost. I had no idea that FSH was essential to pubertal development. I will investigate further.

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