Gynostemma is sometimes called ‘the herb of immortality.’ While it’s an exaggeration to claim that this supplement could make you immortal, it could make you feel that way by boosting the immune system, increasing energy, and reducing stress. Learn more about these benefits below.
What Is Gynostemma?
Gynostemma (also called jiaogulan) has a long history of use in herbal medicine, where it is nicknamed the “immortality herb.” It is also called “poor man’s ginseng” due to providing similar benefits and costing less when compared to Panax (Asian) ginseng .
Additionally, gynostemma produces another type of potentially beneficial compounds called gypenosides that may also benefit the immune system, promote high energy levels, and provide cellular protection .
Benefits of Gynostemma
Insufficient Evidence for:
The following purported benefits are only supported by limited, low-quality clinical studies and some animal research. There is insufficient evidence to support the use of gynostemma for any of the below-listed uses. You may take gynostemma if your doctor considers that it may be helpful in your case. Remember that gynostemma should never be used as a replacement for approved medical therapies.
In a clinical trial on 72 healthy people, gynostemma leaf extract lowered anxiety from chronic psychological stress .
2) Weight Loss
In a clinical trial on 80 obese people, supplementation with gynostemma extract for 12 weeks reduced body weight and fat mass .
Drinking gynostemma tea for 12 weeks reduced blood sugar levels before meals and insulin resistance in a clinical trial on 24 people with type 2 diabetes .
A complex carbohydrate isolated from gynostemma had similar effects in diabetic mice .
Supplementing gynostemma may improve insulin sensitivity by activating the energy sensor AMPK, as seen in cell-based studies .
4) Liver Health
Gynostemma extract may support healthy liver function in a variety of diseases.
In a clinical trial on 56 people with non-alcoholic fatty liver disease, gynostemma extract (as an add-on to conventional therapy) reduced liver cell death (liver damage markers AST and ALP), body mass index, and insulin resistance .
It also prevented the growth of cancer cells, possibly slowing disease progression .
5) Cardiovascular Health
Compounds in gynostemma extract may help to maintain healthy blood flow and prevent excess arterial narrowing. Because they don’t widen arteries that are already open, gynostemma is less likely to cause unpleasant side effects like flushing and nasal congestion when compared with other drugs and supplements .
Gynostemma extract improved energy levels in cells and may aid recovery from exercise .
Gynostemma extract also helps prevent electrolyte imbalances, which can strain the cardiovascular system .
Animal and Cell Research (Lack of Evidence)
No clinical evidence supports the use of gynostemma for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed should not be interpreted as supportive of any health benefit.
Gynostemma treatment lowered multiple inflammatory molecules associated with allergies in animal studies:
- Gynostemma stabilizes mast cells and reduces histamine production 
- Gynostemma reduces airway inflammation caused by Th2 cytokines [37, 3, 38]
- Gynostemma reduces the activation of inflammatory astrocytes 
Preliminary evidence suggests that gynostemma extract protects brain cells from damage.
Moreover, gynostemma is being studied in rats as part of a potential treatment for recovery from stroke .
Laboratory animals under excessive stress learn new skills more slowly. Treating stressed animals with gynostemma reduced these negative changes in learning rates .
Gynostemma extract protected cells from damage in an animal model of Parkinson’s disease .
Higher doses of the extract provided greater protection, which shows promise for a close relationship between supplementation and protection .
Antioxidant and Immunomodulatory
Gynostemma extract increased the levels of both beneficial immune cells and antioxidant enzymes in animal models of immune suppression .
Also, gynostemma extract neutralized free radicals in cell studies .
Gynostemma is also an activator of AMPK, which also protects cells by boosting available energy. These effects may contribute to the cellular protection observed in the studies .
Below, we will discuss some preliminary research on the anticancer activity of gynostemma. It’s still in the animal and cell stage and further clinical studies have yet to determine if its compounds are useful in cancer therapies.
Do not under any circumstances attempt to replace conventional cancer therapies with gynostemma, its components, or any other dietary interventions. If you want to use them as supportive measures, talk to your doctor to avoid any unexpected interactions.
Gynostemma extract reduced the spread of colon cancer in an animal model .
Compounds extracted from gynostemma prevented lung cancer from spreading in human cell studies .
Chronic elevation of the Th2 system is a risk factor for developing breast cancer, colorectal cancer, and pancreatic cancer. Gynostemma may reduce this risk because it reduces excess Th2 inflammation [33, 34, 35].
Information on Using Gynostemma
Because gynostemma is not approved by the FDA for any conditions, there is no official dose. Users and supplement manufacturers have established unofficial doses based on trial and error. Talk to your doctor before supplementing with gynostemma and never use it to replace what your doctor recommends or prescribes.
Gynostemma leaves can be prepared and consumed as a tea. Gynostemma tea has been used in smaller studies as well as in traditional medicine.
A standardized extract delivers a higher concentration of the beneficial compounds, but there are no well-controlled studies to recommend an optimal dosage.
Gynostemma Side Effects and Caution
Keep in mind that the safety profile of gynostemma is relatively unknown given the lack of well-designed clinical studies. Therefore, the list of side effects and drug interactions is not a definite one. You should consult your doctor about other potential side effects based on your health condition and possible drug or supplement interactions.
Gynostemma can increase blood flow, which can increase the side effects of other drugs or supplements that slow blood clotting.
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