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12 Proven Health Benefits of Galantamine Backed by Science (#2 is my favorite)

More than 90 clinical trials have assessed Galantamine‘s impact on Alzheimer’s disease, autism, arthritis, diabetes, and obesity, among others. In this article we explore the science around Galantamine and how it can improve your health.

Introduction to Galantamine

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Galantamine is a nitrogen containing compound that can be obtained synthetically or from the bulbs and flowers of the Caucasian snowdrop (Galanthus caucasicus), Voronov’s snowdrop (Galanthus caucasicus), Galanthus woronowii, Daffodil (Narcissus) and red spider lily (Lycoris radiata ) (RR2R3).

Galantamine has been used for decades in Eastern Europe and Russia for the treatment of muscular weakness (myopathy) and for sensory and motor dysfunction associated with disorders of the central nervous system (R).

Galantamine is commercially available as Nivalin, Razadyne, Razadyne ER, Reminyl, and Lycoremine, and is often used in the treatment of mild to moderate Alzheimer’s disease and various other memory impairments (R).

My Experience With Galantamine

I really love the wakeful promoting, anti-inflammatory, and cognitive enhancing effect that this has.

I do really well with alpha-7 nicotinic agonists.

Amazon has a bunch of supplements for galantamine.

Galantamine Snapshot

Galantamine Snapshot

 Galantamine Supplement
  • Longevity7.0/10
  • Inflammation9.5/10
  • Mood9.0/10
  • Cognition10.0/10
  • Energy7.5/10

Pros

  • Potently boosts cognitive function
  • Relieves symptoms of Alzheimer’s disease
  • Increases insulin senstitivity & normalizes blood sugar
  • May improve symptoms in autistic children
  • Reduces arthritic pain
  • Effective in the treatment of obesity and metabolic syndrome
  • Has potent anti-inflammatory and antioxidant properties

Cons

  • Can cause muscle cramps and weakness
  • Can cause skin problems
  • Can cause urinary incontinence

Health Benefits of Galantamine

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1) Galantamine Improves Cognitive Function

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Mild cognitive impairment (MCI) is a condition that involves a gradual loss of cognitive function over time. MCI sufferers often complain of memory failure. One study gave Galantamine (4 mg twice per day) to sufferers of MCI for 7 days. Patients showed an increase in performance on memory tasks (episodic face-encoding and working memory tasks) (R).

Another similar study demonstrated that patients with MCI had improved episodic memory and reduced reaction times (R).

Cholinergic malfunction may cause memory impairment seen in MCI subjects, which is likely why Galantamine (an acetylcholinesterase inhibitor and modulator of nicotinic acetylcholine receptors) was so effective at improving brain function (R).

Galantamine promotes brain growth possibly via activation of the M1 muscarinic and α7 nicotinic acetylcholine receptors (R).

In mice, Galantamine (at 0.3-3mg/kg) increases brain IGF-2 levels, which may explain its ability to increase growth of new brain (R).

Galantamine is an effective treatment for common forms of dementia such as vascular dementia and Alzheimer’s disease. Many patients benefit from Galantamine therapy that is initiated early, soon after diagnosis, and continued for at least 1 year (R).

Galantamine combines increases the concentration and action of acetylcholine in the brain, thereby relieving some of the symptoms of Alzheimer’s disease (RR1R2).

A key sign of Alzeheimer’s disease is a decrease in hippocampal episodic memory function, due to the build up of  β-amyloid plaques which cause a break down of cholinergic signalling. Galantamine is a useful treatment for Alzheimer’s as it increases hippocampal (an area of the brain that is linked to learning and memory) function via improving cholinergic neurotransmitter function  (R, R1).

Galantamine helps limit the cognitive decline associated with Alzheimer’s disease. This effect was shown to persist for at least 36 months of Galantamine treatment, suggesting that there is is long term potential for Galantamine’s use (R).

In fact, long-term Galantamine treatment may delay an individual’s placement in a nursing home (R).

Long-term treatment with Galantamine increased the connections between neurons in the brains of Alzheimer’s patients (R).  These neuronal connections help stabilize cognitive performance (R).

Galantamine reduced the amount of beta-amyloid plaques in the brains of mice with Alzheimer’s disease, and also decreased the activity of astrocytes, a type of cell in the nervous system that forms “scars” in areas where neurons have been damaged (R).

Galantamine may have antidepressant effects (R) and improve sleep quality in dementia patients (R).

Galantamine has been found to be just as effective as Donepezil, a cognition enhancing medication commonly used to treat Alzheimer’s disease (R).

Galantamine is far more cost-effective than conventional Alzheimer’s treatment with the usual cholinesterase inhibitors (R).

It should be noted that much of the research regarding Galantamine and degenerative brain disorders has been done on rodents. One study showed that primates (our closer relatives) show the same cognitive benefits, but milder ones (R).

2) Galantamine Reduces Inflammation

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Galantamine decreases brain inflammation (R).
Galantamine exerts anti-inflammatory effects by modifying NF-κB, TNF-α, visfatin & adiponectin (R).
Galantamine activates the cholinergic anti-inflammatory pathway; one of the fundamental anti-inflammatory pathways in human biology, which protects the body from prolonged exposure to systemic inflammation. This pathway is activated by through α7 nicotinic acetylcholine receptors (α7 nAChR) (RR1R2).
Activating the cholinergic anti-inflammatory pathway in such a way as Galantamine does can reduce pro-inflammatory cytokine production by an impressive 50–75% (R).
Galantamines suppresses systemic inflammation by decreasing the breakdown of acetylcholine through acetylcholinesterase inhibition (R).

3) Galantamine Is an Antioxidant

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Oxidative stress can cause a lot of health issues in the human body, such as Alzheimer’s, Parkinson’s, Huntingtons, Down’s syndrome, cancer and diabetes (R).

Galantamine is an antioxidant that can protect the cells from oxidative stress (R).

Galantamine protects the brain from neuronal damage from reactive oxygen species (ROS). (It activates NRF2 and protects mitochondria) (R).

4) Galantamine May Protect Against Toxins

In rats, Galantamine protected against the effects of toxic poisoning (with diisopropylfluorophosphate) (R).

Galantamine was shown to protect rats from endotoxins in the blood (by lowing levels of pro-inflammatory cytokines and MPO activity) (R).

5) Galantamine May Treat Diabetes

Galantamine provides anti-diabetic action by improving insulin signaling pathways (p-insulin, p-Akt, GLUT4 & GLUT2 receptors) (R, R1, R2).

Galantamine delayed high blood sugar, reduced immune cell activity in the pancreas, and decreased the production of anti-insulin antibodies in mice with type-1 diabetes (R).

6) Galantamine May Treat Obesity

When Galantamine is administered  to mice with high fat diet-induced obesity, it significantly lowers inflammation, body weight, insulin resistance and cholesterol levels (R, R1).

7) Galantamine Induces Lucid Dreaming

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A lucid dream is a dream in which an individual is aware that they are dreaming and often has some control over their dreams.

Galantamine may enhance lucidity in dreams by altering the cholinergic system and increasing levels of acetylcholine in the brain (R).

I would not take Galantamine too often before bed as, while it can increase lucid dreaming, it can also impair sleep quality by increasing time spent in REM sleep stage (R).

8) Galantamine Can Alleviate Symptoms of Autism

Galantamine given to autistic children, alongside Risperidone (an antipsychotic medication),  improved symptoms of autism, such as irritability, lethargy, and social withdrawal (R).

Stimulation of the central nervous system’s (CNS) serotonergic subsystem (neurotransmitter system that regulates mood and cognitive functions) with Galantamine may enhance expressive language and communication in autistic adults (R).

More clinical trials are needed to study Galantamine therapy in autistic patients (R).

9) Galantamine May Help Treat Schizophrenia

Galantamine may counteract the damaging effects of kynurenic acid, of which increased levels have been associated with cognitive problems characteristic of schizophrenia (R).

Galantamine improves the AMPA-mediated signaling pathway which could protect the brain and improve memory in schizophrenics (R).

10) Galantamine Relieves Arthritis

Galantamine suppresses arthritic inflammation in rats with low testosterone. The appearance of dopamine in the spleen during Galantamine treatment may serve as a marker of its protective action under androgen-deficient conditions (most people over 40 are probably androgen-deficient) (R).

11) Galantamine May Help You Quit Smoking 

Alcoholics who took Galantamine on a daily basis smoked on fewer days and had less total cigarettes compared to patients who took a placebo. Even without taking other initiatives or intentions to reduce smoking, smoking behavior was reduced (R).

12) Galantamine Protects Against Brain Trauma

Electroconvulsive therapy (ECT) is an effective treatment for psychotic patients who have not responded to drugs, but it causes cognitive impairment (R). One study found that Galantamine supplementation protected against a loss in learning abilities if given during and after a treatment with ECT (R).

Rats injected with Galantamine prior to having an artificially induced stroke (low oxygen levels in brain for 2 hours) were found to have less brain damage than rats that were not given Galantamine. Galantamine treated rats had lower levels of inflammatory IL-1B and microglial accumulation (R).

In patients with post-traumatic palsy, Galantamine accelerated the resolution of post-traumatic eye problems (R).

Other

Galantamine and activation of nicotinic receptors leads to the release of endogenous cannabinoids such as anandamide (R).

Adverse Effects of Galantamine

Common side effects of Galantamine include muscle cramps and weakness, cardio-respiratory events, skin problems, and urinary incontinence. Taking high doses of Galantamine without building up slowly may also cause nightmares and anxiety (R).

In addition to these effects, Galantamine’s interaction with other drugs may cause health problems. It is advised to limit usage of Galantamine when taking certain other medications that are metabolized via the same liver pathway (hepatic cytochrome system) (R).

Thankfully, most of the above side effects are rare and can probably be avoided with sensible dosing.

Buying Galantamine

A good starting dosage is 4mg, while 8mg is closer to what I take.

Here are some good options for Galantamine supplements:

Amazon’s Bestsellers

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Galantamine
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Galantamine - Lucid Dreaming & Nootropic Supplement - 4 Mg - 60 Tablets
  • IMPROVE MEMORY AND RECALL - Increases overall levels of acetylcholine in the brain
  • INCREASE DREAM INTENSITY - Galantamine increases the vividness and intensity of dreams
  • INDUCE LUCID DREAMS - Galantamine supplementation is commonly used to improve the liklihood of lucid dreaming.
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