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16 Lactobacillus gasseri (L. gasseri) Probiotic Benefits

Written by Biljana Novkovic, PhD | Last updated:

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Lactobacillus gasseri

L. gasseri is a probiotic that recently gained in popularity, due to its weight-reducing, obesity and metabolic syndrome-combating properties. This amazing probiotic boosts your immunity, helps with allergies, and has many other beneficial properties.

What is Lactobacillus gasseri?

Lactobacillus gasseri is a lactic acid bacteria that elicits various health benefits through its antimicrobial activity, bacteriocin production, and immunomodulation of the innate and adaptive systems [1].

Health Benefits of L. gasseri

1) Lowers Cholesterol

A synbiotic product containing L. gasseri and inulin reduced total blood cholesterol, low-density lipoprotein (LDL)-cholesterol and triglycerides in hypercholesterolemic men and women [2].

L. gasseri significantly reduced the blood and liver cholesterol in rats [3, 4, 5].

2) Helps You Lose Weight

L. gasseri significantly decreased BMI, abdominal visceral fat, waist and hip circumferences, and body fat mass in healthy Japanese adults. However, constant consumption of this probiotic may be required to maintain this effect [6].

Despite there being no change in behavior or diet, administration of L. gasseri modestly reduced weight and waist and hip circumference in obese and overweight adults [7].

L. gasseri significantly decreased body weight and visceral and subcutaneous fat areas in adults with obese tendencies [8].

L. gasseri reduces body weight and fat tissue mass in mice [9] and rats [10].

L. gasseri prevents weight gain in obese mice [11].

3) Combats Obesity

L. gasseri prevents abdominal fat accumulation [12] and decreases body weight in adults with obese tendencies [8].

L. gasseri suppresses lipase-mediated fat hydrolysis in humans [12] and mice [13].

L. gasseri prevents the enlargement of fat cells and an increase in abdominal fat volume in rats, mice, and humans [14, 15, 3].

L. gasseri inhibits dietary fat absorption in rats [16].

L. gasseri ameliorates systemic and fat tissue inflammation in obese mice [14], by inhibiting macrophage invasion [11].

Heat-killed L. gasseri stimulates respiratory immune responses of obese host animals to enhance their natural defense against respiratory infection [17].

However, L. gasseri was shown to significantly reduce leptin concentrations in rats [15, 3, 18].

4) May Lower Glucose and Improve Glucose Tolerance

L. gasseri increases energy expenditure and reduces blood glucose, improves glucose tolerance and attenuates inflammation in rats [19].

It also reduces insulin levels in rats [18].

5) May be Beneficial in Diabetes

L, gasseri decreases blood glucose and improves glucose sensitivity in type 2 diabetic mice [20].

6) May Improve Metabolic Syndrome

L. gasseri decreases food and energy intakes and improves body weight, insulin resistance, and cholesterol levels in rats with metabolic syndrome (MS) [21].

7) Boosts Immunity

Heat-killed L. gasseri enhances immunity in the elderly. This probiotic increases the number of CD8(+) T cells and reduces CD28 expression loss in CD8(+) T cells [22].

Heat-killed L. gasseri increases natural killer cell (NK cell) activities and enhances cell-mediated immunity in aged host animals, thereby altering age-related immunosenescence [23].

Live and heat-killed L. gasseri protect mice against the influenza virus and ameliorate infection symptoms by stimulating local and systemic immune responses [24, 25].

L. gasseri exhibits anti-herpes virus (HSV-2) activity [26].

8) May Reduce Inflammation

L. gasseri prevents high-fat-diet-induced inflammation and lowers the ratio of inflammatory-type macrophages to anti-inflammatory ones in fat tissue of mice [14].

L. gasseri ameliorates systemic and fat tissue inflammation in obese mice [14, 11].

9) Beneficial for the GI Tract

L. gasseri beneficially modifies the microbiota by increasing Bifidobacteria and decreasing Clostridium in human subjects [27].

Heat-killed L. gasseri accelerates the resolution of symptoms and reduces mortality of enteropathogenic E. coli -infected mice [28].

L. gasseri May Ameliorate Diarrhea

L. gasseri increases IgA levels in breast milk and reduces the incidence of diarrhea in mouse pups with rotavirus infection [29].

L. gasseri May Heal Ulcers

Yogurt containing L. gasseri significantly inhibits the formation of gastric ulcers in rats in a dose-dependent manner [30, 31, 32].

10) Combats H. pylori

L. gasseri suppressed H. pylori and reduced gastric mucosal inflammation in infected patients [33].

A 4-week treatment with L. gasseri -containing yogurt improves the efficacy of triple therapy in patients with H. pylori infection [34].

L. gasseri yogurt suppresses dyspeptic symptoms in H. pylori-infected patients [35].

L. gasseri significantly prevents both H. pylori and H. suis infections in mice [36, 37].

11) Combats Candida

L. gasseri yogurt prevents proliferative and inflammatory changes in the stomach caused by C. albicans in mucosal candidiasis in rats [38].

12) Prevents Allergies

Heat-killed L. gasseri improved nasal symptoms and pollen-specific IgE levels in subjects with Japanese cedar pollinosis [39].

L. gasseri enhancing the Th1 immune responses in subjects with perennial allergic rhinitis [40].

L. gasseri enhances oral tolerance in allergies in mice by increasing the ratio of effector regulatory T cells [41].

Heat-killed L. gasseri suppresses eosinophilia in cedar pollen antigen-challenged mice, by modulating the Th1/Th2 balance [42].

13) May Alleviate Asthma

L. gasseri attenuates allergen-induced airway inflammation and IL-17 pro-inflammatory immune response in mice with allergic asthma [43].

14) Combats Fatigue

L. gasseri ingestion prevents reduced natural killer (NK) cell activity due to strenuous exercise and elevates mood from a depressed state in university-student athletes [44].

L. gasseri and αLA alleviate minor resting fatigue in university-student athletes after strenuous exercise [44].

15) Beneficial in Endometriosis

L. gasseri improves menstrual pain and dysmenorrhea in patients with endometriosis [45].

L. gasseri inhibits the growth of endometrial tissue in the abdominal cavity in mice and rats [46].

16) Degrades Oxalate

L. gasseri degrades oxalate in laboratory experiments and may be beneficial in managing oxalate kidney stone disease [47].

Technical

  • Increases IgA in infections [48], increases the IgG2a/IgG1 ratio [42], and decreases IgE in allergies [40].
  • Increases TLR2 [48] and BAFF [48].
  • Increases TGF-β [48], and TNF-α [49, 25, 28, 21] [a study where TNF-α is decreased: 43].
  • Increases IL-1β [28] and IL-2 [25, 23] in infections, but decreases the rate of proliferation and IL-2 production by CD4+ T in allergy [41].
  • Mostly increases IL-6 [48, 28, 21] [a study where it is decreased: 43].
  • Decreases IL-8 [37] and IL-17A [43].
  • Increases IL-10 [48, 49, 41, 28], IL-12 [49, 25, 28, 42], IL-15 and IL-21 [25].
  • Increases IFN-γ [25], and IFNAR [23].
  • Increases perforin 1 [25].
  • Increases intracellular glutathione [49], and GLUT4 [18].
  • Decreases CCL2, CCR2, Lep, Nos2 [11], sICAM-1 [14], ACC1, FAS and SREBP1 [9, 18].
  • Increases high-molecular-weight adiponectin [8].
  • Increases ACO, CPT1, PPARα, PPARδ [18].
  • Increases Mx1 and Oas1a genes, critical for the viral clearance [24].
  • Decreases CSF2 [42].
  • Decreases serum amyloid P component [19].
  • Increases PGE2 [32].
  • Increases Th1 cells in allergies [40].
  • Increases CD8(+) T cells, maintains CD8(+)CD28(+) T cells and lymphocyte transformation [22].
  • Inhibits the proliferation of CD4+ T cells and associated inflammatory responses [50].

Safety

Probiotics are generally considered safe. However, the use of probiotics should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms.

To enhance your health even more, we recommend trying out our Lectin Avoidance Diet Cookbook as well. It makes avoiding inflammation causing lectins easier than ever.

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About the Author

Biljana Novkovic

PhD
Biljana received her PhD from Hokkaido University.
Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. She is passionate about releasing the most accurate science & health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. She believes that SelfHacked has the best science that is also layperson-friendly on the web.

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