L. gasseri  is a probiotic that recently gained in popularity, due to its weight-reducing, obesity and metabolic syndrome-combating properties. This amazing probiotic boosts your immunity, helps with allergies, and has many other beneficial properties. To enhance your health even more we recommend trying out our Lectin Avoidance Diet Cookbook as well. It makes avoiding inflammation causing lectins easier than ever.

What is Lactobacillus gasseri?

Lactobacillus gasseri  is a lactic acid bacteria that elicits various health benefits through its antimicrobial activity, bacteriocin production, and immunomodulation of the innate and adaptive systems (R).

Health Benefits of L. gasseri

1) L. gasseri  Lowers Cholesterol

A synbiotic product containing L. gasseri  and inulin reduced total blood cholesterol, low-density lipoprotein (LDL)-cholesterol and triglycerides in hypercholesterolemic men and women (R).

L. gasseri  significantly reduced the blood and liver cholesterol in rats (R,R,R).

2) L. gasseri  Helps You Lose Weight

L. gasseri  significantly decreased BMI, abdominal visceral fat, waist and hip circumferences, and body fat mass in healthy Japanese adults. However, constant consumption of this probiotic may be required to maintain this effect (R).

Despite there being no change in behavior or diet, administration of L. gasseri  modestly reduced weight and waist and hip circumference in obese and overweight adults (R).

L. gasseri  significantly decreased body weight and visceral and subcutaneous fat areas in adults with obese tendencies (R).

L. gasseri  reduces body weight and fat tissue mass in mice (R) and rats (R).

L. gasseri  prevents weight gain in obese mice (R).

3) L. gasseri  Combats Obesity

L. gasseri  prevents abdominal fat accumulation (R), and decreases body weight in adults with obese tendencies (R).

L. gasseri  suppresses lipase-mediated fat hydrolysis in humans (R) and mice (R).

L. gasseri  prevents the enlargement of fat cells and an increase in abdominal fat volume in rats, mice, and humans (R,R,R).

L. gasseri  inhibits dietary fat absorption in rats (R).

L. gasseri  ameliorates systemic and fat tissue inflammation in obese mice (R), by inhibiting macrophage invasion (R).

Heat-killed L. gasseri  stimulates respiratory immune responses of obese host animals to enhance their natural defense against respiratory infection (R).

However, L. gasseri  was shown to significantly reduce leptin concentrations in rats (R,R,R).

4) L. gasseri  May Lower Glucose and Improve Glucose Tolerance

L. gasseri  increases energy expenditure and reduces blood glucose, improves glucose tolerance and attenuates inflammation in rats (R).

It also reduces insulin levels in rats (R).

5) L. gasseri  May be Beneficial in Diabetes

L, gasseri  decreases blood glucose and improves glucose sensitivity in type 2 diabetic mice (R).

6) L. gasseri  May Improve Metabolic Syndrome

L. gasseri  decreases food and energy intakes, and improves body weight, insulin resistance and cholesterol levels in rats with metabolic syndrome (MS) (R).

7) L. gasseri  Boosts Immunity

Heat-killed L. gasseri  enhances immunity in the elderly. This probiotic increases the number of CD8(+) T cells and reduces CD28 expression loss in CD8(+) T cells (R).

Heat-killed L. gasseri  increases natural killer cell (NK cell) activities and enhances cell-mediated immunity in aged host animals, thereby altering age-related immunosenescence (R).

Live and heat-killed L. gasseri  protect mice against the influenza virus and ameliorate infection symptoms by stimulating local and systemic immune responses (R,R).

L. gasseri exhibits anti-herpes virus (HSV-2) activity (R).

8) L. gasseri  May Reduce Inflammation

L. gasseri prevents high-fat-diet-induced inflammation, and lowers the ratio of inflammatory-type macrophages to anti-inflammatory ones in fat tissue of mice (R).

L. gasseri  ameliorates systemic and fat tissue inflammation in obese mice (R,R).

9) L. gasseri  is Beneficial for the GI Tract

L. gasseri  beneficially modifies the microbiota by increasing Bifidobacteria and decreasing Clostridium in human subjects (R).

Heat-killed L. gasseri  accelerates the resolution of symptoms and reduces mortality of enteropathogenic E. coli -infected mice (R).

L. gasseri  May Ameliorate Diarrhea

L. gasseri  increases IgA levels in breast milk and reduces the incidence of diarrhea in mouse pups with rotavirus infection (R).

L. gasseri  May Heal Ulcers

Yogurt containing L. gasseri  significantly inhibits the formation of gastric ulcers in rats in a dose-dependent manner (R,R,R).

10) L. gasseri  Combats H. pylori

L. gasseri  suppressed H. pylori and reduced gastric mucosal inflammation in infected patients (R).

A 4-week treatment with L. gasseri -containing yogurt improves the efficacy of triple therapy in patients with H. pylori  infection (R).

L. gasseri  yogurt suppresses dyspeptic symptoms in H. pylori -infected patients (R).

L. gasseri  significantly prevents both H. pylori  and H. suis infections in mice (R,R).

11) L. gasseri  Combats Candida

L. gasseri  yogurt prevents proliferative and inflammatory changes in the stomach caused by C. albicans in mucosal candidiasis in rats (R).

12) L. gasseri  Prevents Allergies

Heat-killed L. gasseri  improved nasal symptoms and pollen-specific IgE levels in subjects with Japanese cedar pollinosis (R).

L. gasseri  enhancing the Th1 immune responses in subjects with perennial allergic rhinitis (R).

L. gasseri  enhances oral tolerance in allergies in mice by increasing the ratio of effector regulatory T cells (R).

Heat-killed L. gasseri  suppresses eosinophilia in cedar pollen antigen-challenged mice, by modulating the Th1/Th2 balance (R).

13) L. gasseri  May Alleviate Asthma

L. gasseri  attenuates allergen-induced airway inflammation and IL-17 pro-inflammatory immune response in mice with allergic asthma (R).

14) L. gasseri  Combats Fatigue

L. gasseri  ingestion prevents reduced natural killer (NK) cell activity due to strenuous exercise and elevates mood from a depressed state in university-student athletes (R).

L. gasseri  and αLA alleviate minor resting fatigue in university-student athletes after strenuous exercise (R).

15) L. gasseri  is Beneficial in Endometriosis

L. gasseri  improves menstrual pain and dysmenorrhea in patients with endometriosis (R).

L. gasseri  inhibits the growth of endometrial tissue in the abdominal cavity in mice and rats (R).

16) L. gasseri  Degrades Oxalate

L. gasseri  degrades oxalate in laboratory experiments and may be beneficial in managing oxalate kidney stone disease (R).


  • L. gasseri  increases IgA in infections (R), increases the IgG2a/IgG1 ratio (R), and decreases IgE in allergies (R).
  • L. gasseri  increases TLR2 (R) and BAFF (R).
  • L. gasseri  increases TGF-β (R), and TNF-α (R,R,R,R) (a study where TNF-α is decreased: R).
  • L. gasseri  increases IL-1β (R) and IL-2 (R,R) in infections, but decreases the rate of proliferation and IL-2 production by CD4+ T in allergy (R).
  • L. gasseri  mostly increases IL-6 (R,R,R) (a study where it is decreased: R).
  • L. gasseri  decreases IL-8 (R) and IL-17A (R).
  • L. gasseri  increases IL-10 (R,R,R,R), IL-12 (R,R,R,R), IL-15 and IL-21 (R).
  • L. gasseri  increases IFN-γ (R), and IFNAR (R).
  • L. gasseri  increases perforin 1 (R).
  • L. gasseri  increases intracellular glutathione (R), and GLUT4 (R).
  • L. gasseri  decreases CCL2, CCR2, Lep, Nos2 (R), sICAM-1 (R), ACC1, FAS and SREBP1 (R,R).
  • L. gasseri  increases high-molecular weight adiponectin (R).
  • L. gasseri  increases ACO, CPT1, PPARα, PPARδ (R).
  • L. gasseri  increases Mx1 and Oas1a genes, critical for the viral clearance (R).
  • L. gasseri  decreases CSF2 (R).
  • L. gasseri  decreases serum amyloid P component (R).
  • L. gasseri  increases PGE2 (R).
  • L. gasseri  increases Th1 cells in allergies (R).
  • L. gasseri  increases CD8(+) T cells, maintains CD8(+)CD28(+) T cells and lymphocyte transformation (R).
  • L. gasseri  inhibits the proliferation of CD4+ T cells and associated inflammatory responses (R).


Probiotics are generally considered safe. However, the use of probiotics should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms.

About the Author

Biljana Novkovic - PHD (ECOLOGICAL GENETICS) - Writer at Selfhacked

Dr. Biljana Novkovic, PhD


Biljana received her PhD from Hokkaido University.

Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. She is passionate about releasing the most accurate science & health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. She believes that SelfHacked has the best science that is also layperson-friendly on the web.

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