e5b3e251875a9850f2b649a362578e2b

Top 23 Science Based Health Benefits of Lithium (orotate, aspartate, carbonate, chloride)

Chemistry Cat: Cats are composed of iron, lithium and neon: FeLiNe

Contents

Is Lithium The Drug Different Than The “Natural” Forms?

There’s a lot of misinformation about lithium.  A lot of mainstream sources (WebMD, for instance) seem to suggest that lithium prescribed as a treatment for depression or bipolar disorder (as carbonate or chloride salts and in higher doses) work differently than over the counter lithium orotate.

All the research I’ve seen talk about the ion lithium, which would make the type of lithium salt, not that relevant except for how bioavailable it is and how capable it is in crossing the brain barrier.

Some people say that the over the counter version – lithium orotate – passes the brain barrier much more efficiently than the other versions.

Even assuming the possibility of some differences in dosage, studies about one form of lithium can very likely be generalized to others.

My Experience

The usual dosage taken is 5 mg, but I decided to take 15 mg to see what would happen. I can say that there’s definitely a subtle cognitive effect. It’s definitely got an anti-depressant and anti-anxiety effect and it seemed to lengthen the period of my circadian rhythm, as I started to feel tired later on.

On the negative side, it made more zoned out.  It also made me feel less attached to everything. The fact that I felt acute effects at 15mg suggests me that lithium orotate passes the brain barrier efficiently, perhaps even more so since a much higher dosage of lithium carbonate is standardly used.

Anyway, I’m glad I did the experiment so that I now know lithium orotate is definitely having an effect and I can use it in my coaching practice.

This suggests that at least some of the benefits of other lithium salts prescribed by doctors can be achieved through the orotate version commonly sold.

The Lithium That I Use

Lithium

  • Longevity9.0/10
  • Inflammation8.0/10
  • Mood9.7/10
  • Cognition9.5/10
  • Energy8.5/10

     Pros

  • Great for emotional balance, including anxiety and depression
  • Improves Cognitive performance.
  • Increases lifespan
  • Increases bone density
  • Improves mitochondria

        Cons

  • May increases IL-8 in the gut
  • May cause some fatigue
  • May inhibit thyroid function a bit

Lithium is an alkali metal, naturally present in trace amounts in minerals, water, soil, and in fruits, vegetables and other plants grown in lithium-rich soil (R).

Lithium plays a role in proper function of several enzymes, hormones, vitamins, growth factors, and immune and nervous system (R).

Aside from helping patients with mental health issues, lithium has a wide and ever-growing list of health benefits.

The Health Benefits of Lithium

1) Lithium is Neuroprotective

Chronic lithium treatment was found to robustly reduce glutamate-induced excitotoxicity mediated by N-methyl-D-asparatate (NMDA) receptors. This effect was at least partly due to lithium’s ability to inhibit the influx of calcium, which mediates NMDA receptor activity. (R)

Therefore, lithium can help mood disorders, Alzheimer’s, diabetes, cancer, and inflammatory and autoimmune diseases (R).

2) Lithium Inhibits Apoptosis

shutterstock_247872679

Lithium increases Heat Shock Proteins (HSPs), which promote folding of proteins, refolding of misfolded proteins, and disposal of abnormal proteins (R).

Among HSPs, HSP70 exerts a wide variety of neuroprotective effects against apoptosis. These effects are mediated by inhibition of GSK-3 (R). Lithium also inhibits GSK-3 (R).

Chronic lithium treatment also has been found to induce the production of Bcl-2, a protein in the frontal cortex that protects cells from apoptosis (R).

3) Lithium Increases Neurotrophic Factors BDNF, NGF, and GDNF

Long-term treatment of cultured neurons with lithium induces BDNF. (R)

BDNF is a major neurotrophin essential for cognitive development, synaptic plasticity, and neuronal survival with anti-depressants and anti-anxiety effects. (R)

This is likely a result of inhibition of GSK-3. (R)

Lithium also increases Nerve Growth Factor (NGF) and Glial-Derived Neurotrophic Factor (GDNF) in the hippocampus, frontal cortex, occipital cortex and striatum (R). NGF and GDNF help increase neuronal survival and plasticity (the ability to regenerate and form new connections) of dopaminergic, cholinergic, and serotonergic neurons in the central nervous system.

4) Lithium Helps Remodel The Brain and Heart (VEGF)

brain_133874900

Lithium treatment increases the production of VEGF, which promotes cell growth and remodeling of the blood vessels after stroke (R).

By increasing VEGF , lithium treatment can help people recover more quickly from a stroke or a heart attack (R).

The likely mechanism is by inhibiting GSK-3 (R).

5) Lithium Induces Autophagy

Autophagy or “cellular self-eating” is when the cells degrade and recycle cellular components to reuse the raw materials (R). It is considered anti-aging, cancer-preventing, and important for neuronal function and survival (R, R2).

Lithium can induce autophagy by depleting inositol independently of mTOR inhibition (which typically induces autophagy) (R).

Because lithium induces autophagy, it may be particularly helpful for neurodegenerative disorders – Alzheimer’s, Parkinson’s, ALS and Huntington’s because these disorders are, in part, characterized by the accumulation of misfolded disease-causing proteins (R).

6) Lithium Increases Neurogenesis and Improves Cognitive Function

Lithium was found to stimulate progenitor and stem cells in cultured brain hippocampal neurons (neurons from the memory center). In addition, lithium prevents the loss of proliferation induced by glutamate or cortisol (glucocorticoids). Long-term lithium treatment then promotes the conversion of these progenitor cells into neurons.  (R)

In addition, chronic lithium treatment not only enhances neurogenesis in the hippocampus (memory center) of normal mice but also restores neurogenesis in the brain in an animal model of Down’s syndrome (R).

It also increases neurogenesis in the subventricular zone, the only other place except for the hippocampus (memory center) that it’s been found to occur, causing a sustained increase in gray matter volume in patients (R).

Lithium increases N-acetyl aspartate (NAA) (R), which may be a marker of creativity and is correlated with IQ scores (R). One probable effect is more efficient communication between two sides of the brain, which enhances intellectual performance. (R)

Chronic lithium treatment increases long-term potentiation (LTP) in neurons of the hippocampus, which makes the nerve cells more efficient, and thus helps with learning and memory (R).

7) Lithium Can Calm and Stabilize Mood

In animals, lithium consistently decreases exploratory activity and aggression. (R)

Lithium is known to have a calming and mood stabilizing effect in people as well and is used to treat depression, bipolar disorder, and schizophrenia (R).

Lithium carbonate is the drug of choice for control of manic-depressive illness, reducing manic attacks (RR2R3).

Lithium was also shown to be effective for aggressive behavior in people with attention-deficit hyperactivity disorder (ADHD) (R).

The presence of higher than normal levels of naturally occurring lithium in drinking water supplies may reduce suicide rates (R). Part of the explanation could be because lithium increases serotonin synthesis and release (it also decreases norepinephrine) (R).

Lithium increases CCK in the brain and this is part of the mechanism by which lithium prevents mania in bipolar.

8) Lithium Combats Depression

Lithium is one of the best-studied strategies for treatment-resistant depression (R).

Lithium increases serotonin 5-HT1A postsynaptic sensitivity, which is in part responsible for its anti-depressant activity. (R)

Lithium also elevates BDNF (R, R2), which combats depression.

Lithium ameliorates depression in animals, in part, by increasing neural stem cells.

9) Lithium May Be a Potential Treatment for Huntington’s Disease

Lithium prevented nerve cells death in animal models of Huntington’s disease (RR2).

Lithium decreases excessive NMDA receptor function which could potentially counteract increased activation of NMDA receptors that occurs in the brain of patients with Huntington’s disease (R).

Further studies need to be conducted in patients with Huntington’s disease.

10) Lithium Decreases Insulin Resistance

Lithium enhances insulin-stimulated glucose transport and glycogen synthesis in insulin-resistant muscle in rats (R). These effects are dependent on p38 MAPK (R).

Lithium decreases insulin release (R).

Administration of lithium significantly increased glucose transport into muscle cells in response to insulin by 2.5 fold, and also increased insulin responsiveness (R).

11) Lithium Reduces Autoimmunity and Inflammation

Lithium has potent immune-boostering effects (RR2).

By inhibiting GSK-3,  lithium has been found to beneficial in animal models of autoimmune conditions. (R)

Lithium suppresses Th1 cells and interferon gamma (but not Th17 cells). (R)

Lithium has anti-inflammatory effects by decreasing the production of IL-1β and TNF-α, and increasing the production of IL-2, TGF, IL-1RA and IL-10 (R, R2).

However, studies indicate that under certain experimental conditions lithium also has pro-inflammatory effects by increasing production of IL-4, IL-6 and TNF-α (R).

Lithium increases the production of IgG and IgM antibodies (R).

Lithium decreases the production and activity of prostanglandins, thus preventing its negative effect on the immune system (R).

Lithium decreases the frequency and duration of recurrent labial and genital herpes infections, and reduced the occurrence of common colds (RR2)

12) Lithium Supports Bone Health

A study assessed bone mineral density at the hip and lumbar spine in 75 lithium-treated outpatients and 75 normal subjects matched for age, sex, and body mass index. The study found a lower bone turnover state in those receiving lithium. The mean bone density in lithium-treated patients was 4.5% higher at the spine, 5.3% higher at the femoral neck and 7.5% higher at the trochanter (R).

Lithium is associated with a decrease in the risk of bone fractures, and an increase in bone formation (RR2R3).

13) Lithium Can Helps Entrain Our Circadian Rhythm

Lithium is the drug of choice for treating patients suffering from bipolar disorder, which is characterized by the presence of mania and depression (R).

One mechanism by which lithium can help bipolar disorder is by lengthening the circadian rhythm. People with bipolar disorder tend to have a shorter circadian rhythm than the near 24h period (R).

Lithium helps entrain our circadian rhythm more quickly in response to light and darkness (R).

14) Lithium Improves Mitochondrial Function

Lithium treatment of worms increased lifespan and improved markers of health, including mitochondrial energy output (R).

Lithium may improve mitochondrial function by increasing the turnover of dysfunctional mitochondria (R).

Also, lithium inhibits mir-34a, which in turn inhibits NAMPT, the enzyme that makes NAD+ (R, R2). Therefore, lithium probably increases NAD+.

15) Low Dose Lithium Increases Longevity

Researchers have found a positive correlation between lifespan and drinking-water lithium levels.  There was a decreased risk for all causes of death in Japanese neighborhoods with higher lithium levels.

This is also the case in worms. Long-term low-dose exposure to lithium may exert anti-aging capabilities and unambiguously decreases mortality in evolutionary distinct species” (R). The improvements in health were accompanied by improved mitochondrial function. (R)

16) Lithium May Improve Symptoms of Tourette’s Syndrome

Tourette’s syndrome is a neurological disorder, characterized by involuntary muscle movements and uncontrollable vocal sounds (R).

In a small study involving 3 patients, lithium had a better outcome than haloperidol, a commonly-prescribed drug for Tourette’s. Patients who were taking lithium experienced a significant decrease in the number of tics and involuntary vocal sounds. Patients experienced no side effects, and were symptoms free months later (R).

17) Lithium May Help with Tardive Dyskinesia

Tardive dyskinesia is a neurological disorder characterized by involuntary sudden, jerky movements of the face and/or body caused by the long-term use of antipsychotic drugs (R).

Studies showed that lithium significantly reduced the severity of tardive dyskinesia (R, R2, R3).

Lithium decreased agitation and aggression, and improved involuntary movements (R, R2).

However, two large studies failed to report consistent effects of lithium on tardive dyskinesia (R, R2)

18) Lithium Helps with Obsessive-Compulsive Behaviors

Obsessive-compulsive disorder (OCD) is a mental disorder characterized by obsessive thoughts and behaviors (R).

Lithium supplementation is associated with a decrease in symptoms of OCD that are resistant to standard therapy (R).

Compulsive and pathological gamblers also had a good response to lithium supplementation, possibly by regulating dopamine imbalances in the brain (R).

19) Lithium May Relieve Headache

Lithium may reduce the severity of both chronic and episodic cluster headache (R).

Lithium carbonate given before sleep helped with “alarm clock headache” (a headache that affects the elderly waking them from sleep at the same time of the night) (R, R2, R3).

20) Lithium May Be Effective in Anorexia Nervosa

Patients suffering from anorexia nervosa for many years were treated successfully with lithium carbonate (R, R2).

One patient gained 12 kg and the other 9 kg within 6 weeks, and the weight gain was maintained for a year with lithium therapy (R).

However, further studies with lithium are needed to assess its usefulness in anorexia nervosa.

21) Lithium May Be Effective for Treating Alcoholism

Lithium orotate is useful in the treatment of alcoholism.

It was safe, and the side effects were minor such as muscle weakness, loss of appetite, or mild apathy (R).

Lithium carbonate promotes abstinence from alcohol, diminishes subjective symptoms of withdrawal, and delays the time to first drink (RR2).

Patients treated with lithium were much less likely to be rehospitalized for alcoholism rehabilitation during the 18-month follow-up (R).

22) Lithium May Reduce Seizures

The effect of lithium on seizure disorders is still controversial (R).

Some epileptic patients show a statistically significant decrease in seizures frequency as well as improved behavior when treated with lithium (R).

It may be useful in the control of treatment-resistant temporal lobe epilepsy (R).

However, a few epileptic patients experience an increased number of seizures while on lithium (R, R2, R3).

23) Lithium May Relieve Symptoms of Meniere’s Disease

Meniere’s disease is a disorder of the ear that causes severe dizziness, ringing in the ears, hearing loss, and a feeling of fullness in the ear (R).

70% of patients with Meniere’s disease experienced less frequent and severe attacks when on lithium treatment (R).

However, a study with patients given 6 months of lithium and 6 months of placebo showed no difference between the two treatments (R).

 Other

Genetic Factors that Affect Responses to Lithium

5-HTTLPR (SLC6A4) Serotonin Transporter

Subjects with 2 copies of the short form of this gene show a worse response to lithium than those with the long form (R).

Relevant snps: The presence of rs25531 (not in 23andme) may indicate the long form.

GSK3beta -50T/C

This SNP is a source of variability between responses to lithium in bipolar patients, although the results are mixed (R, R2, R3).

The C allele is associated with better response to antidepressants with lithium augmentation (R).

Potential Risks/Negatives

Lithium has numerous side effects and can be toxic at high doses.

The severity of symptoms is generally proportional to the degree of elevation of blood lithium levels (R).

Most Common Side Effects of Lithium

The most common side effects of lithium therapy include (R):

  • headache
  • lethargy and fatigue. This may be a result of a significant reduction in orexin-producing cells and through reducing thyroid function.
  • drowsiness
  • hand tremors
  • muscle weakness
  • nausea/vomiting
  • diarrhea

Symptoms of Moderate Lithium Toxicity

Moderate toxicity (serum lithium concentration =2.0 – 2.5 mmol/L) is characterized by  (R)

  • confusion
  • dysarthria
  • nystagmus
  • ataxia
  • muscle twitches
  • ECG changes (flat or inverted T waves)

Symptoms of Severe Lithium Toxicity

Symptoms of severe toxicity (serum lithium concentration> 2.5 mmol/L) include (R):

  • impaired consciousness
  • seizures
  • syncope
  • kidney insufficiency
  • coma and death

Lithium May Lower Thyroid Function

Lithium decreases production and release of thyroid hormones, thus hypothyroidism is very prevalent among patients on lithium therapy (RR2R3R4).

Studies reported that goiter (enlargement of the thyroid gland) occurred in 50-60% of patients treated with lithium (R, R2R3R4).

Hyperthyroidism occurs rarely, and it is characterized by transient and painless inflammation of the thyroid gland (thyroiditis) due to a possible toxic effect of lithium on the thyroid gland (RR2R3).

Lithium induces thyroid autoimmunity by increasing B cell activity and decreasing ratios of suppressor to cytotoxic T cells (R). As a result, 20% of lithium-treated patients have thyroid auto-antibodies.

Lithium may also be useful in combination with radioactive iodine in the treatment of thyroid cancer (R).

Other Negative Effects of Lithium

  • Lithium is a competitive inhibitor of magnesium, which is part of its mechanism of action (R).
  • Lithium may increase inflammation in the intestines- IL-8 (R) and Nf-kB (R).  If you have colitis or Crohn’s I would not take this. Colitis is caused in part by IL-8 and this increases IL-8 (R).

Special Precautions

  • Pregnancy and breast-feeding: lithium can be toxic to a developing baby and increase the risk of birth defects. It can enter breast milk and cause side effects in a nursing infant
  • Heart disease: lithium should be carefully used in patients with preexisting heart disease because it may cause irregular heart rhythms
  • Kidney disease: lithium removal from the body by the kidneys is decreased in patients with kidney disease, and the risk of lithium intoxication increases considerably in this setting
  • Thyroid disease: lithium may make thyroid problems worse

Lithium Deficiency

Lithium deficiency caused by low dietary intakes, or due to certain diseases (kidney disease especially in dialysis patients) is unlikely to happen in humans.

If deficiency occurs, symptoms are mild and manifest primarily as behavioral problems (R).

Lithium Drug Interactions

Both antidepressant drugs (such as Prozac®, Zoloft®, Elavil®, Anafranil®, Tofranil®) and lithium increase serotonin. Taking lithium with these medications could cause serious side effects such as heart problems, shivering, and anxiety (RR2).

In patients treated with both lithium and an antipsychotic (haloperidol, thioridazine, chlorpromazine, clozapine and risperidone), toxicity to the brain ranges from extrapyramidal symptoms (continuous muscle spasms or jerky movements) to neuroleptic malignant syndrome (RR2R3R4).

Taking lithium along with medications used to prevent seizures, anticonvulsants, (phenobarbital, valproic acid, carbamazepine) may increase the risk of toxic effects from these drugs (RR2).

Medications for high blood pressure (ACE inhibitors- Capoten®, Vasotec®, Prinivil®; calcium channel blockers- Adalat®, Calan®, Cardizem®, DynaCirc®) can increase lithium levels in the body thus increase its side effects (RR2R3R4).

Diuretics, water pills, (hydrochlorothiazide, chlorothiazide, furosemide) increase blood lithium concentrations by reducing lithium removal by the kidneys (RR2),

Non-Steroidal Anti-inflammatory Drugs (ibuprofen, naproxen, diclofenac) decrease lithium removal by the kidneys, and thus increase blood lithium concentrations (RR2R3).

Taking lithium along with muscle relaxants (pancuronium, succinylcholine) might prolong muscle relaxation (RR2).

Taking lithium along with dextromethorphan (Robitussin DM®), meperidine (Demerol®), or tramadol (Ultram®) may increase serotonin in the brain, and cause serious side effects including heart problems, shivering and anxiety (RR2).

Acetazolamide, theophylline, sodium bicarbonate can lower blood lithium concentrations by increasing lithium excretion in urine (R).

Dietary Sources of Lithium

Primary dietary sources of lithium are grains and vegetables, which may contribute from 66% to more than 90% of the total lithium intake (R).

Cacao, oats, seafood (shrimp, lobster, oysters and scallops), seaweed, beef liver, goji berries, various fruits and vegetables (depending on the soil in which they are grown) and egg yolks are significant sources of lithium (R).

Buying Lithium

I generally go for lithium orotate, but lithium aspartate is also fine.

Dosing

If you’re completely healthy, I recommend 1-2 mg a day in the long term. There is an association with low doses of lithium (1-2mg) and longevity (R).

However, I wouldn’t expect to feel anything at that dosage.  I’ve been taking 1mg for quite a few months, with no noticeable effect.  I’ve recently upped it to 5mg.

Positive Reviews From the Web

-These tablets have changed my life, I suffered from severe insomnia for 7 years, tried everything possibly imaginable to relieve my symptoms. This supplement has calmed my mind, and switched off my erratic moods. It has eliminated my emotional attachment to most things in life. I am now far more level headed and deal with situations much easier – life seems less stressful! I take two in the morning with vitamin b and fish oil and one in the afternoon with vitamin b Really recommend this tablet to anyone suffering from any of the above listed symptoms, anyone who has ever questioned their own sanity, dealt with depression, mood swings or those who emotionally attatch themselves to most situations – you will learn to observe life and not absorb it. Best thing i have ever done

-I have spent my whole life, trying to feel better and the deleterious effects of pharmacueticals are not worth the delivery they never produce. I have seriously never felt sustained happiness in my life. I have ADHD and I do not say or do impulsive behavior with this product.I take divided doses of 30 mgs total per day and I am calm. For those who do not suffer, it is unimaginable that one like me had to wait till I was 56 to live my life, calm cool and collected. I feel the smoothness of neurotransmission and sequential duties are no longer an issue. It is my long awaited miracle!! To say I feel JOY is an understatement!!!!!

-fantastic product from a reliable brand. the change in my mood (@5mg/day) was almost immediate and is very pronounced. it seemed to shut off the stress->depression cycle.

-I HAVE BEEN USING RX FOR DEPRESSION AND ANXIETY FOR YEARS…THIS IS BETTER THAN ANY OF THE RX’S I HAVE TAKEN IN THE PAST WITH NONE OF THE SIDE EFFECTS!! I LOVE IT!

-Noticed it calmed me down and regulated my breathing since I am a shallow/irregular breather especially if stressed. This effect was subtle but significant. Liked the product overall and love doctor’s best brand.

-Initially purchased for mother who has alzheimers. I’ve only had her on it for about a week so I have not noticed any difference, however I figured why not try it myself. I have noticed my depression is gone and thoughts of suicide have all but disappeared! I take about 10 mg per day and figure even if it doesn’t help her, I can now cope.

-I love this product… it has brought me back to my true self. The price and the reviews caught my attention. I’ve struggled with social anxiety and depressive/manic phases for decades and tried antidepressants/antianxiety medications to no avail and comitted to finding a natural regimen instead. I’ve been taking one tablet daily sometimes a second in times of extreme stress along with vitamin c, iron, time release multi, easily digestible protein shake, and a good Fish Oil/DHA+EPA each day. At first I was taking it before bed but started taking it the morning about a month ago. It induces a sense of calm, clarity and presence. I’m able to interact with ppl more spontaneously, sleep better, and think/judge more clearly. I suggest that if anyone wants to try this, research and use with accompanying nutritional supplements. It started working for me on day 1 and I hope others discover this incredible product. Shipping to Canada took a while but I was checking the mailbox obsessively each day for the delivery.

-My husband and I both take this. No noticeable effect, but after the first week I realised we hadn’t had any outbursts of temper, or any fits of depression. Six weeks later, and the one cranky episode followed a missed tablet. I was undiagnosed cyclothymic, and with Lithium I find the unstable, silly racing head and the dull unmotivated head don’t happen. Instead I feel balanced and stable. My husband had anger management problems which, amazingly, he doesn’t have any more. We both take one or two tablets a day. They have no effect on my sensitive stomach, but for the first week or so I had to carry a bottle of water around to deal with the extra thirst. This works so well I’m a little anxious in case it becomes unavailable.

-I don’t write to many reviews but I had to for this supplement. I have been on Paxil for 5 years and had just been informed that my insurance company was raising the price on my meds. It became to expensive for me so I went looking for something else I could replace it with. I read the reviews for this Lithium and decided to try it. FYI my main issue is anxiety. I weaned myself off of the antidepressant and started taking this in its place. Well, It works! Im not having the bad withdrawals that can come with getting off of Paxil and so far, I feel great! I will continue to take this.

-My response to lithium orotate was so overwhelmingly positive, I suspect some sort of conspiracy is afoot to keep it from public knowledge. Problems with Anxiety, Insomnia, Moodiness – completely solved with this nutrient. I can’t recommend it enough.

-Excellent product. I purchased this for my 17 year old daughter who has been trying to give up her addiction to Marjiuana and has suffered from rage attacks and severe irritability. Her mood has completely evened out and she no longer suffers with irritability. Which means we all no longer suffer from her irritability. I am so pleased to have found this product on iherb

Amazon’s Bestsellers

Bestseller No. 1
NCI Advanced Research Dr. Hans Nieper Lithium Orotate Tablets, 120 mg, 200 Count
  • Formulated by hans a nieper, MD of hannover, germany
  • Dietary Supplement
  • As an addition to the daily diet, take one tablet twice a day with meals or as directed by your health care professional
SaleBestseller No. 2
Weyland: Lithium Orotate - 5mg of Elemental Lithium per Vegetarian Capsule
  • Each bottle of Weyland: Lithium Orotate contains 60 vegetarian capsules.
  • Lithium Orotate is a trace mineral that may help support and balance mood.*
  • Lithium Orotate is a form of Lithium that is combined with orotic acid, which is thought to increase bioavailability relative to other forms.*
  • All Weyland products are manufactured in the USA at an FDA inspected cGMP and 3rd party rated facility
  • We guarantee your satisfaction, or we will refund 100% of your purchase, including shipping costs for up to one bottle of Weyland: Lithium Orotate per customer

Comments

  1. Melanie R Jones

    Lithium ruined my life. It did nothing for my depression but it immediately piled on 100 pounds, gave me diabetes and probably influenced the development of carcinoid syndrome. It’s not the wonder drug for everyone.

  2. jane

    What is the actual dose of the Lithium ions in mg in the lithium orotate 5mg dose?

    Does the reported 1.5 mg dose on the Trace Minerals label refer to the Lithium ions only? I would assume so, since the salt is dissolved in the solution, but the label does not so state.

    Thanks,
    Jane

  3. RK

    Where do you find lithium orotate 1mg? The lowest dose I can find is 5mg and that is with n acetyl-cysteine. I do not tolerate n acetyl-cysteine. Thanks.

  4. Emmie

    We live in Europe. My daughter takes 400mg lithium carbonate a day for BiPolar Disorder. She is doing well and works successfully in a creative job. She does have lithium induces skin problems and problems with her intestines ( not every day ) . Would extra magnesium and inositol be bad for her ? She takes now active B vitamins and magnesium ( and more ).
    Would it be a good idea for her to ask for lithium orotate and then in a lower dose ?
    ( I understand perfectly weel if you do not know the answers ).

    Next week we will try your SelfDecode.

    • Kelly

      Be cautious the bi carbonate version your daughter is taking is very different from orotate. Orotate crosses the blood brain barrier where as bicarbonate does not, hence the high dosage. With lithium Orotate a very small dose is all that is required to effect a positive outcome with little side effects.

  5. I just started it yesterday. I am amazed how calm I feel. I have autoimmune and stuggle with brainfog, ear ringing, poor memory, inflammation, insomnia, anxiety and depression. My ear ringing is less, I can think clearer and my inflammation is a lot less. Brain fog and fatigue is a lot better. I have chronic fatigue. I am hoping it will reverse some of my brain issues. I am 50 and am tired of feeling like I am 90.

      • Tina

        Dante….I did not post but want to comment and the only way I could figure was to hit reply….I noticed less aggression in 2 hours….No LIE….I was honestly FRANTIC FRANTIC FRANTIC on the day I started this and HONESTLY felt better in 2 hours. I thought this feeling was Pychosymatic but after reading all the others and the immediate and dramatic effects I would have to say YES it works VERY QUICKLY : )

  6. DC

    I have a rage disorder along with obsessive thoughts. 30 mg of this lithium orotate daily has dramatically changed my life. I feel that 40 mg is what my brain needs. Is this okay long term? Will I need to discontinue for my upcoming surgery? I really do not want to stop taking it. Thank you for your time.

  7. Oh help help! I’m looking for a comparison of liquid ionic lithium and lithium orotate. I’ll divide each 5mg capsule into 3 capsules every day for the rest of my life if I have to but it sure would be nice to switch to the liquid. I just want to be certain of dosage. Can’t say enough about it, except it’s too bad I had to suffer from anxiety, mood swings, difficulty focusing, side effects of prescription meds for over 50 years before I found lithium orotate.

    • Kelly

      Check your facts before you start spouting incorrect information please. This discussion is about Lithium Orotate Not Bi Carbinate !! Do your research

    • Cristobal

      Two of the big differences is that oratate is absorbed better and crosses the “blood-brain-barrier” more effectively, meaning much smaller doses can be used. The doses used in l.carbonate are close to toxic and need to be monitored. My ex-wife actually went toxic on a prescribed dose and suffered amnesia for a while (the real kind, not the fictional version). The above poster mentions pharmaceutical lithium is “300+ stronger”, but what I think he means is that many times the amount of lithium carbonate is needed to provide the same amount of lithium ions to the brain. Why haven’t medical practitioners switched? It cost at least tens of millions of dollars to do the effectiveness and safety tests. Pharmaceutical companies need to forecast high profit margins to do these tests and market the alternative forms of lithium. That money just isn’t there according to finance. In a way, lithium carbonate is a kind of scam by neglect. Think Big Pharma and medicine isn’t capable of that? Tell me where the new antibiotics that are so desperately needed? Why are so many dying of hospital infections. If you want better living through chemistry, you need to do your own research.

  8. loane

    I used one capsule of lithium orotate 5mg from Swanson… my blood glucose from 88mg/dl went to 136mg/dl. Is this normal?

  9. Simi

    Some research shows Lithium orotate to be beneficial for Inflammatory bowel disease but this article says not to take in Crohn’s??

  10. Devildog

    Hi Joseph,

    In my Lithium Orotate studies, I just came across your site. I am on the tail end of 61 and have been burdened by Adult ADD for decades. All of my life actually looking back. Conventional drugs had more negative effects than positive, so I couldn’t continue with them. And so called natural remedies failed to work miserably. Then a few weeks ago I stumbled across information about lithium orotate on the internet and I have been reading everything I can get my eyeballs since.

    Today is my second day of taking 20mg of it. I determined that 20 mg once a day is more than safe since this form of lithium has not proven to be toxic at much higher dosages. I believe it is a high enough dose to have an affect, if it is going to have an affect on me and I am withholding judgment for at least 30 days…unless I get a positive/negative result too obvious to ignore earlier. Too early to report any affects yet, but I am highly encouraged by all of the research (although no large scale trials have been performed that I have read of) and testimonials from users across the web about how it has finally solved their or their children’s various issues that meds and other remedies had failed to perform or presented too many negative side effects to be able to enjoy any positive benefits received.

    I am looking for relief from issues around lack of focus and the inability to stay on task for any length of worthwhile time. As well as with maintaining motivation to finish projects. The suggested long term benefits regarding increased general brain health will be appreciated also, but immediately, help with lack of focus and my brain from switching channels too often to allow for completing tasks in a timely manner or at all.

    Great site you have here. I will sign up for updates. Thanks.

  11. Samantha

    Hi! Are there any other drugs, supplements, or herbs that should not be mixed with Lithium Orotate? I’d like to know before I start taking it.

  12. Kevin

    Question: Do you think that chronically administered, small (+-6mg) doses of lithium orotate would, over time, increase the amount of grey matter in the brain? I believe the studies point to a therapeutic level of lithium used for 4 weeks or so… Thanks!

  13. JoAnn

    “This confirms that the benefits of other lithium salts prescribed by doctors can be achieved through the orotate version commonly sold.”
    Suggest “that some of the benefits”

  14. Lithium Orotate

    Thanks for getting the word about lithium orotate out there. Your site is very helpful and the community thanks you for it. Keep up the great work man

  15. And don’t forget it’s impact on thyroid physiology. Lithium is not an antipsychotic. It is used as a mood stabilizer particularly effective for suicidal ideation and behaviors in bipolar depression and mania both of which can occur without psychotic symptoms per se, psychotic symptoms being defined as symptoms/ signs indicating lack of insight/ judgment/decision making logic out of conjunction with consensual reality (that is for a philosophical/ linguistic discussion). Lithium also works through the inositol system: http://www.bipolar-lives.com/inositol-and-bipolar.html and http://en.wikipedia.org/wiki/Inositol_monophosphatase. Due to the narrow therapeutic vs toxic window for lithium dosing it’s probably to the well being of all beings to state a very strong caveat that dosing for recreational experimentation is highly likely to cause irreversible cerebelar damage and we know how much we hate that when it happens. Thanks for this treasure trove work in progress.

  16. Britt

    I’m thinking that some bipolar is caused by a mild form of thyroid instability, switching back and fourth between hypo and hyper and the reason MDs put patients on such high doses that almost cause toxicity and almost always cause tremors is they need to see a stabilization affect sooner rather than later–instead of letting it build up over months and letting the patient’s body get used to it. But that’s an anecdotal guess.

    But really how much of Medical Science is just guesses anyway, a ton of persciption meds I see say “Medicationon is thought to work by XYZ.” emphasis on the “is thought.”

  17. Lithium @ 2.5mg increases symptoms and increases anxiety, should I be tested for Crohns, again? Or is there anything else you can advise for me to do?

  18. Hi, Can you give reference to where you found Lithium Orotate increasing IL-8 and can make intestinal issues such as Chron’s worse? I only find studies that show it helps reduce intestinal inflammation?

  19. K

    Joe you say about not taking smart drugs as you are better off taking natural stuff instead so how is this any different as it is a drug after all, Why cant you just eat veg and fruit would that not do the job, Is it because of this freaking modern world? Can it ever just be simple? You are a smart man.

  20. Rae

    Taking lithium orotate for 2 months. First month a miracle!! Nothing bothered me and Now I feel irritable anxiety and pissed off mode all the time. Any suggestions???

  21. chris

    I have two questions. One is I’ve been taking orotate because I read one review saying it was the best then I recently saw one saying orotate can lead to cancer. What are your thoughts on this? My second question is what time of the day do you take it? I’ve been doing the morning but I read on another forum someone said they take it at night and it helps them go to sleep. If that’s the case is taking it in the AM making me tired during the day?

  22. Ooo I’ll try this out. I had a question though, I know that the prescription lithium requires blood tests to make sure it doesnt get to toxic levels. I assume with this OTC lithium the dose is too low to warrant blood tests or is it due to something else?

    • Selfhacked

      Hi CC,
      you are correct in that it’s the lower dosage that makes it less toxic. Supposedly it gets absorbed better so you need to take less.

    • With Lithium Orotate the delivery mechanism is straight into the blood and brain allowing for much lower dose which is no. Toxic levels. Lithium carbonate on the other hand requires massive amounts to a hive the same effect which can be very toxic. Bottom line stick with over the counter Orotate

Leave a Reply