In early 2015, doctor and investor Joon Yun launched the Palo Alto Longevity Prize, a one million dollar award for any scientist who could “hack the code of life” and find a way to keep humans from aging. Since then, there has been a surge of new research into longevity enhancement in an attempt to win this prize. This article will explore some of the longevity research that has gone into various supplements.
The following supplements have only been studied in animals or cells. None of these supplements have been studied in clinical trials. The safety and effectiveness of these supplements in humans are unclear.
It’s also important to let your doctor know of all the supplements you are currently taking, in case of potential interactions. These supplements should not be used to replace medical treatment.
A study in rats suggests that C60 dissolved in olive oil may improve longevity. In the study, rats that received oral administration of C60 lived nearly twice as long. The researchers theorize that this life-extending effect may be due to a reduction in oxidative stress .
According to some researchers, the potential life-extending effects of curcumin may be due to its ability to decrease the expression of age-related genes (including mTOR). There’s also evidence that curcumin has antioxidant effects [4, 5].
According to some researchers, oxaloacetate may be associated with longevity because it can potentially reduce the build-up of methylglyoxal, which is linked to protein toxicity and cellular dysfunction .
Rhodiola rosea is an adaptogenic herb that is purported to help improve stress resilience.
Research suggests that R. rosea may increase longevity according to several animal models, including flies, worms, and yeast. This effect was seen in both sexes and was independent of dietary restriction .
A study performed in yeast cells found that carnitine may be associated with lifespan. According to researchers, supplementation with carnitine may improve mitochondrial health, which may play a role in aging [12, 13].
In one fly study, flies fed NAC lived 26.6% longer compared to flies that were not treated with NAC .
Another study found that supplementation with NAC increased the lifespan of worms by up to 30.5% .
The association between NAC and longevity may also involve NAC’s effect on the expression of specific mRNA genes .
Increases in the longevity of fruit flies, mice and rats have been observed when melatonin was given supplementally or added to their food .
Research in both mice and rats also suggests that melatonin may act as an antioxidant that can potentially inhibit free radical damage .
According to cell studies, melatonin may affect the expression of genes that govern the cell cycle, cell/organism defense, protein expression and transport, and mitochondrial function. It might also activate the same sirtuin pathways as caloric restriction (SIRT1) .
According to some researchers, lactic acid may increase lifespan by removing hydroxyl radicals .
In a fruit fly study, gluconic acid increased the lifespan of flies by 12-22% depending on what stage of life supplementation began .
Like lactic acid, gluconic acid may increase lifespan by removing hydroxyl radicals .
However, malate did not extend the lifespan of worms that were also calorie restricted.
According to a study in worms, acetic acid may help increase the lifespan of worms by increasing DAF-16. This extension of lifespan was 30-40% greater when acetic acid was combined with Reishi extract .
Activated charcoal is able to absorb substances from the digestive tract and is sometimes used to help eliminate toxic substances from the stomach.
A study in male rats suggests that activated charcoal may help increase longevity. According to researchers, activated charcoal may delay age-related structural changes by absorbing toxic compounds .
Lutein is an abundant carotenoid in fruits and vegetables.
In a study looking at fruit flies, lutein prolonged the average lifespan of flies by 63% .
According to a fly study, supplementation with black tea extract rich in theaflavins may extend the lifespan of flies by approximately 10%. The study also suggests that this extract may increase resistance to the negative effects of a high-fat diet .
Research in flies suggests that D-chiro-inositol may slow the aging process and enhance longevity .
Feeding a form of butyrate to flies increased their maximum lifespan by 30-50%, according to one fly study .