GLP-1 is a hormone that is capable of causing weight loss and some good cognitive effects.
Introduction to GLP-1
Glucagon-Like Peptide-1 (GLP-1) is both a neuropeptide and an incretin.
A neuropeptide is an agent that has effect on nervous system. An incretin is a hormone that reduces glucose levels in blood.
1) GLP-1 Benefits Type 2 Diabetic Patients and Balance Blood Glucose
GLP-1 is found to delay the speed of digesting food, or stomach emptying. In this way, GLP-1 reduces the speed of glucose intake, making it easy for body to maintain blood sugar level right after a meal until the next meal. (R)
Fat muscle cells also increase glucose uptake when GLP-1 is increased. (R)
Patents with type 2 diabetes produce low level of GLP-1 and increasing the level of GLP-1 can be a good way to treat type 2 diabetic patients. (R)
A 6 weeks long administration of GLP-1 to type 2 diabetic patients resulted in weight loss, reduction in appetite, slowed stomach emptying, high sensitivity to insulin, and improved beta cells function with no other major side effects. (R)
However, GLP-1 has a very short half-life of about 1.5 minutes, and is rapidly suppressed by an enzyme called dipeptidyl peptidase-4 (DPP-4). (R)
2) GLP-1 Decreases Appetite
GLP-1 influences nervous system to decrease the appetite.
In particular, a study using chocolate milk has shown that GLP-1 reduces the excitement of eating food, anticipatory food reward, which may result in decrease in appetite and motivation toward food. (R)
3) GLP-1 May Help Brain Function
One immediate advantage of GLP-1 is the ability to reduce glucose level in the blood.
In animal models, GLP-1 has anti-depressant effects (R).
Other Effects of GLP-1
Negatives of GLP-1 Activation
GLP-1 can increase the stress response (R).
A study has shown that GLP-1 and GLP-1R may be responsible for stress responses such as increased blood pressure and increased heart rate. This function of GLP-1 may be connected to maintaining the balance of energy usage. (R)
How to Increase GLP-1
Sugar (both glucose and fructose) increases GLP-1 as a satiety signal.
The following are my preferred GLP-1 increasers:
I get the most benefits from the first 5 from this list.
- Resistant starch/prebiotics (R, R2) – Hi-maize Resistant Starch
- Butyrate (R)
- Modified Citrus Pectin
- Bile/TGR5 Agonists (R) – also Oleanolic acid/olive leaf, Betulinic acid/chaga.
- Olive oil/Oleic acid/MUFAs (R, R2).
- Cinnamon (R),
- Raw honey -Contains Fructose/Fructans (R, R2)+Glucose (R) – instead of other carbs
- Palatinose (R) – instead of other carbs
- Berry and Citrus
- Chlorogenic acid -very potent (R)
- Olive leaf extract (R)
- Grape Seed Extract (R)
- Berberine (R)
- Resveratrol (R)
Other natural GLP-1 increasers:
- Ginseng (R),
- Alpha-linolenic acid/Flax/Chia (R)
- Inulin/FOS (R),
- Guar Gum (R),
- Whey (R),
- Soy (R),
- Glutamine (R),
- Bitter melon (R),
- Quercetin (R),
- Sucralose/Splenda (R),
- Pea protein,
GLP-1 Activators (Drugs):
DPP-4 Inhibitors (Drugs):
Another way to increase the effectiveness of GLP-1 is by reducing the function of DPP-4.
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
HOW WOULD YOU RATE THIS ARTICLE?