Grapefruit seed extract is full of nutrients and is a great source of antioxidants. It also contains vitamins and minerals that help keep you healthy. Read more below to find about the health benefits that grapefruit seed extract can provide.

What is Grapefruit Seed Extract?

Grapefruit seed extract is a liquid extract derived from the seeds, pulp, and white membranes of grapefruit. The extract is made by grinding the grapefruit and juiceless pulp and mixing it with glycerin (R). It is sold as a food supplement as well as being used in cosmetics due to its antimicrobial properties (R).

The estimated percentage of the U.S RDA claimable for ascorbic acid was 70% for grapefruit juice products (R).

GSE contains flavanones naringin and hesperidin [R4].

Grapefruit Seed Extract Snapshot


  • Contains Antioxidants
  • Protects the Heart
  • Increases death of cancer cells
  • Helps weight loss
  • Stops fungal infections


  • Interacts badly with other drugs
  • Contains synthetics.

The Benefits of Grapefruit Seed Extract

1) Grapefruit Seed Extract as an Antimicrobial

Grapefruit Seed Extract has strong antimicrobial activity against both gram-positive and negative bacteria [R2].

Grapefruit Seed Extract which immediately reduced pathogen levels in a beef model of E Coli [R3].

An alcohol extract of grapefruit seed exhibited the strongest antimicrobial effect against Salmonella enteritidis and exhibited various antimicrobial effects against other strains [R4].

Grapefruit Seed Extract has antimicrobial properties against gram-positive and gram-negative bacteria by disrupting the membranes of bacteria [R5].

2) Grapefruit Seed Extract and Gastric Lesions

Stomach ulcers that were pretreated with the extract were reduced by 50% as well as improvement of stomach blood flow and increased mucosal generation of PGE2 and antioxidant activity [R6].

Grapefruit Seed Extract was capable of reducing stress and alcohol-induced ulcers [R7, R8].

3) Grapefruit Seed Extract as an Antifungal

It was determined that Grapefruit Seed Extract has a potent antifungal activity against the Candida Albicans [R10]. Grapefruit Seed Extract was stronger than cranberry juice against candida [R9].

Yeast cells can have induced programmed cell death due to grapefruit seed extract. Grapefruit Seed Extract has strong antifungal properties and destroys the mitochondrial ribosomal protein which leads to the death of the yeast cells [R11].

4) Grapefruit Seed Extract as a Diabetes Treatment

Diabetic rats were used to determine the effect of Grapefruit Seed Extract and its lowering effect on glucose and lipids. Rats that were treated with the extract exhibited significant decreases in total cholesterol, total triglycerides, and low-density lipids, which was similar effects to the popular drug metformin [R14].

Rats were studied to determine Grapefruit Seed Extract’s effect on lowering blood glucose levels and lipids as well as decreasing cardiovascular disease risk factors. Rats that had received the extract had a reduced risk for cardiovascular disease. The extract may also be able to manage type-2 diabetes [R15].

5) Grapefruit Seed Extract and Pancreatic Damage

Rats with acute hemorrhagic pancreatitis induced by 30 min partial pancreatic ischemia (blood restriction) were treated with Grapefruit Seed Extract. When treated with the extract, pancreatitis decreased. Grapefruit Seed Extract reduced the pancreatitis-induced lipid peroxidation [R12].

6) Grapefruit Seed Extract as Mouthwash

Grapefruit seed extract can be used as mouthwash due to its antimicrobial properties. It is a good natural supplement to be used because it also exhibits direct action on host cells due to its antioxidant, immunoregulatory, analgesic, buffering, and healing properties [R13].

Negative Effects of Grapefruit Extract

1) Grapefruit Extract Negatively Affects Drug Interactions

Grapefruit juice inhibits cytochrome P450 isozymes involved in drug metabolism. This can lead to a possible overdose and dose-dependent adverse effects. This can lead to serious dose-dependent adverse effects (R).

Other grapefruit products besides the juice are also occasionally implicated, including grapefruit seed extract (R).

However, the inhibition of CYP enzymes seems insignificant. The main chemical that inhibits CYP enzymes is furanocoumarin. According to one analysis, grapeseed extract contains 1/1000 of the level in the juice (R). If this is true, then furanocoumarin would have insignificant effects on CYP enzymes.

2) Grapefruit Seed Extract Can Contain Synthetics

The extract has synthetic disinfectants such as benzethonium or benzalkonium chloride. A study showed that 7 out of 9 specimens had these synthetic disinfectants (R).

The grapefruit seed extract sold in the stores is different than the natural seed extract (R).


  • If taken in liquid form, about 10 drops in a cup of water, taken 3 times a day
  • If in tablet form, 100-200mg taken 1-3 times a day.

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The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.