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Does the Weight Loss Pill Lipozene Work and Is It Safe?

Written by Ana Aleksic, MSc (Pharmacy) | Last updated:
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology) | Written by Ana Aleksic, MSc (Pharmacy) | Last updated:

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Lipozene has been attracting attention due to claims that it can curb appetite and boost weight loss without any major lifestyle changes such as diet or exercise. It also can supposedly help control diabetes. But does Lipozene actually work?

What is Lipozene?

Lipozene is marketed as a supplement that helps reduce body weight and fat. Its main active ingredient is glucomannan, which is a complex carbohydrate isolated from parts of the konjac plant (Amorphophallus konjac). Glucomannan supposedly increases feelings of fullness and can fight obesity and diabetes. These properties of glucomannan are what popularized Lipozene as a supplement [1, 2, 3, 4].

Components

The main ingredient of Lipozene is glucomannan, a soluble, fermentable, and highly viscous dietary fiber that can absorb 50x its weight in water. Both soluble and insoluble fiber can’t be digested by humans [1, 5, 6, 7].

Mechanism of Action

Because glucomannan can’t be digested, it can make you feel full despite taking in fewer calories. It can also promote fullness by forming a thick gel and take up space in the stomach as well as delaying the time it takes for food to pass through the stomach and intestines [6, 8].

Does Lipozene Work?

Currently, there are no scientific studies on Lipozene. The manufacturers state that their weight loss claim is based on sales data published in 2013-2018 and that they use Amorphophallus konjac and glucomannan research. Therefore, we will review the main claims of Lipozene (weight loss, diabetes, and safety) based on the available Amorphophallus konjac/glucomannan data.

Natural Sources

There are many natural sources of the main ingredient of Lipozene, such as konjac flour, konjac gum, or konjac glucomannan, which are available as capsules, drink mixes, granules, and tablets.

Potential Uses of Lipozene

1) Weight Loss

A few studies showed that glucomannan can help to decrease weight by promoting satiety by delayed gastric emptying and intestine transit time.

A review of seven clinical trials with an average of 39 participants concluded glucomannan may possess properties that promote weight loss when paired with either a normal or low-calorie diet but more study is needed. It also reduced the rate of food absorption in the small intestine leading to smaller post-meal blood-sugar and insulin spikes [9].

In two trials with 103 overweight or obese people, 3 g/day glucomannan reduced body weight and total and LDL cholesterol levels [10, 11].

Another trial of 50 obese people determined glucomannan added to a low-calorie diet was more effective than diet alone [12].

Similarly, obese people lost excess weight and reduced triglycerides and cholesterol levels by taking 2-3 capsules, 2x/day of glucomannan with a balanced diet (53 people) [13].

While a diet supplemented with 3 g/day glucomannan reduced body mass, body fat, total cholesterol, and LDL cholesterol, adding exercise improved body composition and HDL levels, and the HDL/triglycerides ratio [14].

2) Improving Diabetes Symptoms

In a study with 22 diabetics, 3.6 g/day glucomannan decreased fasting but not post-meal blood sugar levels [15].

1 g glucomannan treatment prior to a sugar test reduced blood sugar spikes but didn’t affect insulin levels of 20 diabetics in a trial [16].

A clinical trial of 40 women with PCOS showed that glucomannan reduced glucose and insulin levels, especially when combined with inositol [17].

Another study of 34 women demonstrated that 3g/day glucomannan decreased blood glucose levels in both diabetic and non-diabetic groups [18].

In another trial of type 2 diabetics, glucomannan also controlled ghrelin levels (the hunger hormone) [19].

However, a study of 11 type 2 diabetes patients showed that glucomannan supplementation with a traditional diet and drug regiment did not affect blood sugar or insulin levels or body weight [20].

Limitations and Caveats

While there are studies on the effect of the main ingredient, glucomannan, on weight loss and diabetes, no studies have tested Lipozene. Thus, there is no direct evidence that Lipozene has any efficacy or is safe to use.

The studies performed with glucomannan were mostly conducted with humans but some were based on experiments with animal models or cell lines. More data are needed to establish exactly if and how glucomannan works.

Because the main ingredient comes from a natural product, several factors can affect the final quality of the supplement. Cultivation and harvesting, post-harvest handling, and manufacturing practices will all affect the quality and consequently the therapeutic value of the final herbal products [1].

Side Effects & Safety

Glucomannan has low toxicity levels with no evidence of psychotropic activity (meaning it doesn’t affect mental states) and appears to be well tolerated. However, in one case report, glucomannan supplements may have caused severe hepatitis, indicating a potential for the presence of impurities [21, 22, 23].

The glucomannan tablets may swell up in the throat and become a choking hazard, if not taken with enough water [24].

Lipozene may indirectly affect low blood pressure by dramatically decrease blood glucose which might affect diabetics and patients with low blood pressure [25].

Pregnant or Breastfeeding?

Intake of Lipozene should be monitored in pregnant or breastfeeding women since pregnancy and breastfeeding are calorically demanding processes [26].

Drug Interactions

In general, Lipozene may interact with any medication taken orally, as the fiber can delay absorption of medications in the intestine.

Since glucomannan has been shown to lower blood sugar, discuss with your doctor if you’re taking the following medications/supplements that affect blood sugar [20, 15]:

Glucomannan reduces the absorption of sulfonylurea medications and may reduce the bioavailability of other oral medications that are taken at the same time. Therefore, oral medications should be taken 1 hour before or 4 hours after ingesting Lipozene [27].

Dosage

Lipozene

The manufacturers of Lipozene recommend a dosage of 2 capsules, 30 minutes before meals, with at least 8 oz (~250 mL) water, up to 3x/day.

Glucomannan

The optimal daily dosage of glucomannan for weight loss is 1 g, 3x/day, 1 hour before meals. Higher doses, ranging from 3.6 – 13 g/day, were recommended for managing diseases such as type 2 diabetes, insulin-resistance syndrome, and high cholesterol [9].

Lipozene Reviews

Users positive experiences include:

  • Effective at controlling blood sugar levels
  • Weight loss true effects
  • Hunger control
  • Improvement of constipation symptoms
  • Lowering cholesterol
  • Improved insulin resistance in polycystic ovarian syndrome

However, some also report:

  • Dizziness
  • Nausea
  • Bloating
  • Gas

One user complained about the cost of taking the supplement on a daily basis.

Buy Lipozene/Glucomannan

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About the Author

Ana Aleksic

MSc (Pharmacy)
Ana received her MS in Pharmacy from the University of Belgrade.
Ana has many years of experience in clinical research and health advising. She loves communicating science and empowering people to achieve their optimal health. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. She is a strong advocate of integrating scientific knowledge and holistic medicine.

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