S-Adenosyl-L-Methionine affects cellular function. It can help treat dementia and neurological disorders, liver diseases, and depression. Read more below to learn about its health benefits.



S-Adenosyl-L-methionine also referred to as SAM, AdoMet or SAMe, is of great importance in living organisms (R).

SAMe occurs naturally in the human body and is synthesized from methionine (R).

Any changes in the availability of S-Adenosyl-L-methionine in the body affects cellular function. Abnormalities in its metabolism often result in liver diseases and neurological disorders (R).

Therefore SAMe has been used orally to treat liver diseases, fibromyalgia, affective disorders such as depression and neurological disorders, dementia and Alzheimer’s disease (R).

The SAMe That I Recommend

Health Benefits of SAMe

1) S-Adenosyl-L-Methionine Improves Depression


Major depression is a common mental health disorder and for some patients, the standard method of treatment is often inadequate (R).

Sometimes the use of a supplementary medicine, such as high-dose s-adenosyl-l-methionine, along with antidepressant medication has proven to be beneficial (R).

SAMe produces therapeutic effects similar to common antidepressants and is relatively toxic free (R).

It has a faster onset than some conventional antidepressants and is tolerated in high dose (R, R).

2) SAMe Helps Treat Liver Disorders

SAMe helps restore liver function in the presence of chronic liver diseases such as alcoholic and non-alcoholic cirrhosis as well as cholestasis (R).

SAM also prevents or reverses hepatotoxicity due to drugs like paracetamol and steroids (R).

SAMe reduced liver dysfunction in humans who had alcoholic cirrhosis over a two year period (R).

3) SAMe Improves Brain Function


Cerebrospinal fluid (CSF) SAMe levels are significantly lower in severely depressed patients and in patients with Alzheimer’s or dementia. Treatment with SAM increased CSF SAMe and improved moods and brain function (R).

SAMe is linked to the folate cycle and vitamin B12 metabolism which provides methyl groups required for SAMe mediated methylation reactions (R). Mice raised on a diet deficient in vitamins B6 and B12 increased Alzheimer’s like features (R).

SAMe inhibits the increase of progression of these Alzheimer’s like features and also improves spatial memory (R).

4) S-Adenosyl-L-Methionine Treats Osteoarthritis

Osteoarthritis is associated with pain, stiffness and reduced range of motion in the body. SAMe alleviates the discomfort associated with osteoarthritis (R).

When tested on humans for knee osteoarthritis, it has a slower onset than other medication and there was no real difference in pain tolerability (R).

5) SAMe Reduces Symptoms Associated with Sjögren’s Syndrome and Fibromyalgia


Fibromyalgia or fibrositis is a painful, nonarticular, non-inflammatory condition predominantly involving muscles (R, R).

It can occur alone or in conjunction with other connective tissue disorders such as Sjögren’s Syndrome. This syndrome is an autoimmune inflammatory disease that mainly affects mouth and eye glands (R).

In female patients with both conditions, SAMe usage drastically reduced the number of tender points and painful areas (R).

Patients with these conditions tend to have moderately severe depression. However, treatment with antidepressants worsen the oral and eye symptoms associated with Sjögren’s Syndrome. SAMe is an effective treatment as it improves mood without exacerbating these symptoms (R).


  • S-Adenosyl-L-Methionine acts as a methyl donor in transmethylation reactions.Methylation reactions are critical in numerous cellular processes ranging from gene expression to membrane fluidity (R).
  • The liver is responsible for the regulation of SAMe as it is the major site of its synthesis and degradation (R).
  • SAMe is important in three biochemical pathways: transmethylation, transsulfuration, and aminopropylation.
  • When SAMe molecules release methyl groups this results in the activation of the transsulfuration pathway which leads to the formation of glutathione (R).
  • Glutathione is a cellular antioxidant responsible for detoxification of compounds in the body such as lead and paracetamol. These reactions show why SAMe is effective in treating liver diseases (R).
  • SAMe is responsible for numerous transmethylation reaction such as those involving the synthesis of neurotransmitters (R).
  • Antidepressants inhibit the reuptake of neurotransmitters, for example, serotonin. However, SAMe ‘s role as a methylating agent enhances synthesis of neurotransmitters associated with moods such as serotonin, norepinephrine, and monoamines (R).

Side Effects

  • Stomach Problems (R)
  • Anxiety (R)


For treatment of liver disorders such as cholestasis, scientists recommend 800 mg parenterally or 1600 mg orally of SAMe (R, R).

For depressive illnesses, scientists recommend 200 to 400 mg per day for 15 to 20 days. (R).


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  • Nancy Smith

    I am unable to tolerate SAM E. I am sure it is due to one of my genes or variances. But it seems I would need it.Isn’t there a b vitamin with a small amount of SAM E

  • Daniel Crawford

    Sam-e gives me gum recession. Which is a real shame as I find it very uplifting.

  • John Macgregor

    FYI, I doubt if most people would experience sfx with SAMe, but I & a few others do, & they are most unpleasant & take a couple of weeks to abate.

  • Emilie

    In the reference for the negative effect Anxiety, there came another article ( about knee pain ).
    kind regards from Europe, France

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