S-Adenosyl-L-methionine (SAM-e) affects cellular function. It helps to treat dementia and neurological disorders, liver diseases, and depression. Read more below to learn more about the health benefits of SAM-e.
- The SAM-e That I Recommend
- Health Benefits of SAM-e
- Side Effects
S-Adenosyl-L-methionine, also referred to as SAM, AdoMet, or SAM-e, is of great importance in living organisms (R).
SAM-e occurs naturally in the human body and is synthesized from methionine (R).
Any changes in the availability of S-Adenosyl-L-methionine in the body affects cellular function. Abnormalities in energy production often result in liver diseases and neurological disorders (R).
Therefore, SAM-e has been used orally to treat liver diseases, fibromyalgia, mood disorders such as depression and neurological disorders, dementia, and Alzheimer’s disease (R).
The SAM-e That I Recommend
Health Benefits of SAM-e
1) S-Adenosyl-L-Methionine Improves Depression
Major depression is a common mental health disorder and for some patients, the standard method of treatment is often inadequate (R).
Sometimes the use of a supplementary medicine, such as high-dose S-Adenosyl-L-methionine, along with antidepressant medication has proven to be beneficial (R).
SAM-e produces therapeutic effects similar to common antidepressants and is relatively toxic free (R).
2) SAM-e Helps Treat Liver Disorders
SAM-e helps restore liver function in the presence of chronic liver diseases such as alcoholic and non-alcoholic cirrhosis as well as cholestasis (R).
SAM-e also prevents or reverses liver toxicity due to drugs like Tylenol and steroids (R).
SAM-e reduced liver dysfunction in humans who had alcoholic cirrhosis over a two-year period (R).
3) SAM-e Improves Brain Function
Cerebrospinal fluid (CSF) SAM-e levels are significantly lower in severely depressed patients and in patients with Alzheimer’s or dementia. Treatment with SAM-e increased CSF SAM-e and improved moods and brain function (R).
SAM-e inhibits the increase of progression of these Alzheimer’s-like features and also improves spatial memory (R).
4) S-Adenosyl-L-Methionine Treats Osteoarthritis
Osteoarthritis is associated with pain, stiffness and reduced range of motion in the body. SAM-e alleviates the discomfort associated with osteoarthritis (R).
When tested on humans for knee osteoarthritis, it has a slower onset than other medication and there was no real difference in pain tolerability (R).
5) SAM-e Reduces Symptoms Associated with Sjögren’s Syndrome and Fibromyalgia
Fibromyalgia or fibrositis is a painful, nonarticular, non-inflammatory condition predominantly involving muscles (R).
It occurs alone or in conjunction with other connective tissue disorders such as Sjögren’s Syndrome. This syndrome is an autoimmune inflammatory disease that mainly affects mouth and eye glands (R).
In female patients with both conditions, SAM-e usage drastically reduced the number of tender points and painful areas (R).
Patients with these conditions tend to have moderately severe depression. However, treatment with antidepressants worsen the oral and eye symptoms associated with Sjögren’s Syndrome. SAM-e is an effective treatment as it improves mood without exacerbating these symptoms (R).
- S-Adenosyl-L-methionine acts as a methyl donor in transmethylation reactions. Methylation reactions are critical in numerous cellular processes ranging from gene production to membrane fluidity (R)
- The liver is responsible for the control of SAM-e, as it is the major site of its synthesis and degradation (R)
- SAM-e is important in three biochemical pathways: transmethylation, transsulfuration, and aminopropylation
- When SAM-e molecules release methyl groups, this results in the activation of the transsulfuration pathway which leads to the formation of glutathione (R)
- Glutathione is a cellular antioxidant responsible for detoxification of compounds in the body such as lead and Tylenol. These reactions show why SAM-e is effective in treating liver diseases (R)
- SAM-e is responsible for numerous transmethylation reactions, such as those involving the synthesis of neurotransmitters (R)
- Antidepressants inhibit the reuptake of neurotransmitters, for example, serotonin. However, the role of SAM-e as a methylating agent enhances synthesis of neurotransmitters associated with moods such as serotonin, norepinephrine, and monoamines (R)
For depressive illnesses, scientists recommend 200 to 400 mg per day for 15 to 20 days. (R).
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