54 Science-Backed Ways to Inhibit Biofilms Naturally (With References)

I’ve been getting more and more people with outstanding infections.

Helping people who have chronic infections can be tricky because they are most likely to react to supplements, which is why such people often require a ‘slower’ approach (one that lessens reactions).

Identifying infections can also be really tricky.  Is it bacterial, fungal, parasitic or viral?

Biofilms make the equation more complex, because even if someone took an anti-microbial that would kill their infection, biofilms can prevent this from happening.


What Are Biofilms

Biofilm formation occurs when free-floating microorganisms attach themselves to a surface and create a colony (R).

They secrete materials (extracellular polymers) that provide a structural matrix that adheres to surfaces (R).

About 80% of human infections affecting the gut, mouth, sex organs, lungs, heart, teeth, eyes, ear, and skin are caused by biofilm-associated microorganisms (R).

Antibiotics can actually induce biofilm formation (R).

Biofilms may be a reason why some people suddenly do worse for no apparent reason – because after biofilms grow, they disperse.

Biofilms also might be a reason why people herx from herbal supplements.

For example, if you take a supplement that breaks up biofilms, some of the bacterial products can be released, which can cause an immune reaction.

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Why Are Biofilms Bad?

Currently, there is a large sum of money and research aimed at the use of and protection against biofilms (R).

Because biofilms protect the bacteria, infections are often more resistant to traditional antimicrobial treatments, making them a serious health risk (R).

Biofilm bacteria generally tolerate antibiotic treatment (R).

This is because antibiotics can’t pass through the biofilm enough (R).

Biofilms are known to be involved in many chronic infections such as in a chronic wound, lung, ear, heart and nose infections (R).

Most people (59%) with chronic sinus infections were found to have a bacterial biofilm, whereas none of the controls (people who didn’t have a sinus infection) had bacterial biofilm (R).

The most common biofilm that you might be familiar with is the plaque in your teeth (R).

Most, if not all, antibiotics and antiseptics fail to eradicate mature biofilms, and today, the poor efficiency of available antibiotics is a major challenge for the successful treatment of chronic infections (R).

At present, the most efficient treatment for biofilm infection is to mechanically remove the infected area or body part.  This is sometimes possible if the focus is a catheter, an implant, or an infected organ that is eligible for transplantation (R).

So far, the two main strategies for preventing or suppressing bacterial biofilm infections are (1) early aggressive antibiotic treatment before the biofilm is formed or (2) chronic suppressive antibiotic treatment when the biofilm is established if it cannot be removed physically (R).

There are more than one million cases of catheter-associated urinary tract infections reported each year, many of which can be attributed to biofilm-associated bacteria (R).

Catheters have a surface that is conducive for biofilms to form, which is why infections are so common.

In the body, when biofilms form, they form a protective layer by which bacteria evade the immune system and antimicrobials.

Bacteria become tolerant to antibiotics and most other antimicrobial agents (R).

So if you have a fungal or bacterial infection that’s coated with a biofilm, normal antibiotics and antifungals won’t kill the infection.

If you have a bacterial infection that persists despite antibiotic therapy and you have a high level of proinflammatory cytokines, then you either have a biofilm or a nonbacterial infection (R).

How to Inhibit Biofilms: Natural Biofilm Disruptors

When bacteria form biofilms, they don’t lump together by chance.

In order to form biofilms, bacteria need to communicate with each other (R).

One way to disrupt biofilm formation is to interrupt bacterial communication, also known as quorum sensing (QS) (R).

Quorum Sensing Inhibitors interrupt bacterial communication signals, which prevent them from aggregating (R).


  1. Linoleic acid (omega-6) (R, R2, R3),
  2. Oleic Acid/Olive Oil  (RR2),
  3. Honey (R)….Better if you have an infection: Raw Honey+Royal Jelly+Propolis+Bee Pollen (IHERB)
  4. Propolis (candida biofilm) (R),
  5. Apple Cider Vinegar (IHERB) (R) -physiologically tolerable concentrations of acetic acid can completely eradicate bacteria in mature biofilms vitro.
  6. Caprylic acid (G+,-, fungal) (R),
  7. Stevia (R),
  8. Xylitol (R),
  9. Garlic (R, R2),
  10. Manuka (R),
  11. Ginger (R) (G+,-),
  12. Cranberry (R)

Non-Herbal Biofilm Disruptors

  1. Ozone (R, R2)
  2. Chitosan (R, R2, R3),
  3. NAC (IHERB) (R),
  4. Lactoferrin (R, R2),
  5. EDTA (R)….EDTA likely exerts antimicrobial activity by chelating magnesium and calcium – minerals necessary for growth and membrane stability and may also display anti-biofilm activity by reducing biofilm material (EPS) production and/or enhancing the detachment of bacterial cells from the biofilm.  Magnesium, calcium, iron, zinc, and manganese appear to stabilize the biofilm matrix of a variety of organisms by enhancing structural integrity through electrostatic interactions that serve to cross-link the matrix (R).
  6. Zinc (R)
  7. Iron (R)
  8. Manganese (R).
  9. High alkalinity (magnesium)? (R)
  10. Monolaurin (IHERB) (R) (G+),
  11. Colloidal Silver (IHERB) (R),
  12. Zeolite (Acidithiobacillus thiooxidans) (R)
  13. L Reuteri (R).
  14. Citrate? (R) – Calcium Citrate, Magnesium Citrate
  15. Norspermidine (found in chlorella) (R),


  1. Trypsin (R) – found in pancreas glands, Wobenzyme
  2. Serratiopeptidase (R),
  3. Nattokinase (R),

Herbal Biofilm Disruptors

  1. Andrographis (R),
  2. Curcumin (R, R2)
  3. Berberine (R, R2)
  4. Cinnamon/Cinnamaldehyde (R, R2) and Cinnamon essential oil (R),
  5. Black cumin oil/Thymoquinone (R),
  6. Boswellia (R),
  7. Vanilla
  8. Ginkgo
  9. Oregano Oil (carvacrol+thymol) (R),
  10. Quercetin (R),
  11. Apigenin (R),
  12. Naringenin (R),
  13. St John’s Wort (R),
  14. Kaempferol (R),
  15. Rosmarinic acid (higher concentrations) (R),
  16. Baicalein (R, R2),
  17. Neem (R, R2)
  18. Gentian violet (R),
  19. Mangosteen (streptococcus) (R)
  20. Alfalfa (R)
  21. Eugenol (R, R2, R3) – found in Tulsi, clove essential oil and cinnamon essential oil,


  1. Farnesol (R),
  2. D-Amino Acids (R),
  3. Reserpine (R),
  4. Rifampicin (R)


  1. Great article but missed one of THE BEST herbal biofilm disrupters with high broad spectrum antibiotic activity. Oil of Melaleuca alternifolia or Tea Tree Oil. Way past due that this should be near the top of any list. Powerful dispersing agent. Highly active germicide. Well tolerated by skin.

  2. Camille

    Thanks so much for this excellent article! Extremely helpful info! 🙂
    Would L-Cysteine work in the same way as NAC?

  3. Maria

    I think it is worth mentioning that people with any type of biomedical implants are predisposed to Biofilm infection. Biofilm quickly forms are foreign objects in the body and the $2 Trillion Life Sciences Industry is well aware of this problem. The real reason for antibiotic resistant bacteria, and the consequent deaths are biomedical implants placed inside the human body. Crimes against humanity aren’t a problem if the public isn’t informed, right?

    ..clinical and laboratory profile of symptomatic women with silicone breast implants.

    Among 176 breast implant patients examined by doctors at the Hospital for Joint Diseases, Orthopedic Institute in New York City, the most frequently reported symptoms were chronic fatigue (77%), cognitive dysfunction (65%), severe joint pain (56%), dry mouth (53%), dry eyes (50%), hair loss (40%), and difficulty in swallowing (35%).

    Pathogens in Medical Implants


    Biofilms linked to human implants play a large part in antibiotic resistant bacteria (chronic infections)

  4. matt

    i’am on a 108 day grape juice fast it also removes biofilms in the intestines. 7 days in im feeling alot better and you dont want to know about the nightmares that have come out of me.

    • Will I Am

      LOL, What part of ‘Grape’ Juice is beyond your understanding lol…
      No one, on this planet is going to go on a grapefruit seed extract diet for 108 days lol
      Not that it would not have its benefits but….
      Matt is Feasting on “Grape Juice.”

  5. Read Walter Last The Ultimate Cleanse. That’s all you need. I’m on borax and DMSO, colloidal silver, H202, olive leaf extract, slow build up so herx reaction not overwhelming. Turps my next stop. Prosthesis badly implanted and prob infected from jaw infection from crap dentistry. The source of most evils esp if u have root fillings. I have had chronic fatigue for years and am starting to feel normal. It is almost a miracle. W Last a hero in my opinion. Oh and I’m researching Rife/Clark zappers (a minefield and can be expensive…I’m erring on the side of Eastern Europe and Russia science. Patience with this as it takes time; several frequencies oscillate to disrupt a particular pathogen. I’m doing staph and strep to start. If anyone has purchased one , do post on results or not

  6. Alba

    Has anyone yet tried botanical combinations such as Byron White? I’m considering trying; would appreciate some feed-back.

  7. what is non bacterial infection exactly? you mean its one
    of the other 3 groups?
    bacterial, fungal, parasitic or viral, what are the differences
    and how that effect the strategies to be employed?
    will it be addressed in future posts.?

    when i was little i wasnt breast fed and i had a lot of sicknesses as a baby and child and asthma as well.
    i also have allergy issues and stress issues.
    also i seems to have low processing speed.
    lately i had psoriasis. i wonder if all of it connected to infection/s or i just force one cause on it all?

    i wonder..

    just how many of those bastards i have/had? and how much can be caused by it out of everything that happened?

    • Not being breast fed means you did not get the natural immunity of your mother in breast milk so you need to develop your own in other ways. yes the skin problem are a sign of reduced immunity defense. Using as many of the items in his list will help build your immunity. Be consistent and patient- it will happen.

    • matt

      try a very good colostrum. i believe goat colostrum is best for humans do your own research. but i will tell you it does work i have auto immune problem and i took colostrum. and my auto immune raged out of control because it improved my immune system so much. took me a bit to recover from it.

  8. Hmmm, so it looks like essentials oils blends like e.g. “OraWellness HealThy Mouth Blend” can really help with infections in mouth.

    Organic and wildcrafted essentials oils of:
    ~ cinnamon
    ~ peppermint
    ~ spearmint
    ~ clove
    ~ myrrh
    ~ manuka
    in a base of Organic almond oil

    Did you maybe found anything about other essential oils included in this recipe (peppermint, spearmint, myrrh, almond oil because of Linoleic acid and Oleic Acid?)?
    Could they also help with biofilms?

    Maybe I could make something similar myself because I did not found anything similar in Europe.

  9. LQ

    Also lumbrokinase and Cistus incanus. My dental health has improved since I started swishing with Cistus incanus tea. Far less plaque. Also good results from combining monolaurin and olive leaf extract, which caused die-off reaction from some undetermined infection. Also Eva Sapi has found that stevia helps biofilms related to Lyme.

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