Evidence Based

Top 11 Health Benefits of B. bifidum Probiotic + Safety

Written by Biljana Novkovic, PhD | Last updated:
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology) | Written by Biljana Novkovic, PhD | Last updated:

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B. bifidum

B. bifidum is a great probiotic shown to alleviate stress in students. B. bifidum also ameliorates various gastrointestinal disorders and combats infections. It is a great probiotic to supplement with in addition to eating a healthy diet. We recommend the lectin avoidance diet and have created a cookbook to make eating one of the healthiest diets very easy.

What is Bifidobacterium bifidum?

Bifidobacteria account for more than 80% of microorganisms within the intestine and Bifidobacterium bifidum is the second most prominent species found in breast-fed infants [1]. During adulthood, the levels of Bifidobacteria decrease considerably but remain relatively stable (2-14%), decreasing again in old age [2].

Various diseases such as obesity, diabetes, and allergies have been associated with lower numbers of Bifidobacteria at various stages of life [2].



B. bifidum is an important bacterium that inhibits human gut microbiota. This probiotic has significant health benefits, such as reducing irritable bowel syndrome, diarrhea and pathogen infections [1].

Health Benefits of B. bifidum

1) Combats Stress

In academically stressed undergraduate students, B. bifidum increased the proportion of healthy days per participant and decreased the percentage of participants reporting cold/flu during the intervention period [3].

Similarly, B. bifidum reduced self-reported stress and stress associated diarrhea/GI discomfort in undergraduate students [4].

2) Has Antioxidant Properties

B. bifidum exhibits antioxidant activities [5].

3) Beneficial for the GI Tract

B. Bifidum Improves GI Disorders

Fermented milk containing B. bifidum improves symptoms in patients with functional gastrointestinal disorders (FGID). Abdominal pain, diarrhea, and constipation significantly improved, as did acid-related dyspepsia. Psychological symptoms such as anger and hostility also improved [6].

Ingestion of B. bifidum significantly decreased the prevalence of gastric and lower abdominal symptoms in adults taking no medication [7].

B. bifidum alleviates acute gastric injury by enhancing the production of gastric mucin in rats [8].

B. Bifidum Beneficially Modifies Gut Microbiota

Intake of B. bifidum decreased Prevotellaceae and Prevotella and increased Ruminococcaceae and Rikenellaceae in healthy volunteers [9].

Intake of B. bifidum improved the microbiota of the intestinal tract of mice by increasing the number of probiotics (Lactobacilli) and by reducing unwanted bacterial populations (Enterobacter, Escherichia coli) [5, 10, 11, 12].

B. Bifidum May be Beneficial in Inflammatory Bowel Disease (IBD)

B. bifidum decreases symptoms of inflammatory bowel disease (IBD) in mice, such as thickened intestinal wall and inflammatory cell infiltration, and decreased inflammatory cytokine production [13].

B. bifidum shows anti-inflammatory effects in mice with colitis [14, 15] and protects against necrotizing enterocolitis in rats [16, 17].

B. Bifidum Alleviates Irritable Bowel Syndrome (IBS)

B. bifidum effectively alleviates IBS and improves symptoms in IBS patients simultaneously with an improvement of the quality of life [18].

B. bifidum significantly improved the pain/discomfort, distension/bloating, urgency and digestive disorder in patients with IBS [18].

4) Combats H. Pylori

In a human study, B. bifidum improved rates of upper gastrointestinal symptomatic subjects and total symptoms in patients with H. pylori infection [19].

B. bifidum relieves damage to gastric tissues caused by H. pylori and also decreases H. pylori pathogenicity in mice [20].

5) May Lower Cholesterol

B. bifidum decreases total cholesterol, triglycerides, low-density lipoproteins, and very low-density lipoproteins and increases high-density lipoproteins in diabetic rats [21].

B. bifidum lowers cholesterol in laboratory experiments [22].

6) May be Beneficial in Diabetes

B. bifidum decreased fasting blood glucose, HbA1c, total cholesterol, triglycerides, LDL and VLDL and increased HDL, and insulin in diabetic rats [21].

B. bifidum ameliorates oxidative stress, and returns the antioxidant indexes in the pancreas of diabetic rats to normal, with a reduction in lipid peroxidation and elevation in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase [21].

B. bifidum can stabilize blood sugar, lower cholesterol levels in serum, and improve metabolic activity in mice [10].

7) May Boost Immunity and Combat Infections

B. bifidum delays immunosenescence in mice by enhancing the anti-oxidation activity in thymus and spleen and improving immune function [23].

B. bifidum delays the onset of murine rotavirus (MRV) infection associated diarrhea [24, 25].

Galactooligosaccharides (GOSs), produced by B. bifidum reduce Salmonella enterica Typhimurium colonization and its associated pathology [26].

8) May be Beneficial in Allergies

Oral administration of B. bifidum significantly inhibits antigen-induced allergic nasal reactions such as sneezing and nasal obstruction in guinea pigs [27].

Similarly, prolonged oral administration of B. bifidum suppresses Japanese cedar pollen-induced allergic nasal symptoms in guinea pigs [28].

B. bifidum significantly decreases airway hyperresponsiveness in allergic mice, decreases lung inflammation and lowers the Th2 response [29, 30].

9) Good for the Skin

B. bifidum has a positive effect on the prevention and treatment of eczema in infants [31].

B. bifidum decreases the amount of intracellular melanin and exhibits antioxidant properties in mice, and may be beneficial as a skin-whitening ingredient in various skin hyperpigmentation disorders [32].

10) May be Beneficial In Lupus

Intestinal dysbiosis, characterized by a reduced Firmicutes/Bacteroidetes ratio, has been reported in systemic lupus erythematosus (SLE) patients [33]. B. bifidum supplementation prevents CD4+ lymphocyte over-activation, and may potentially help in restoring the Treg/Th17/Th1 imbalance present in SLE [33].

11) May Combat Cancer

Extracts of B. bifidum inhibit the growth of colorectal cancer cells in the laboratory [34].


  • Increases IgA, IgM, and IgG [35], and decreases IgE [30].
  • Inhibits the Th1 response and reduces pro-inflammatory cytokines IL-1β, IL-6, keratinocyte-derived chemokine (KC) and the COX-2, MPO [14] and MCP-1 [13] in colitis.
  • Can also increase the expression of TLR-2, COX-2, and PGE2 [36].
  • Suppresses IL-8 and NF-κB signaling pathways in H. pylori infection [37].
  • In aging, B. bifidum stimulates the immune system, significantly increases cytokine IL-2 and IFN-γ levels but decreases proinflammatory cytokines IL-6 and TNF-α concentration [23].
  • In allergies, B. bifidum IL-4 and IL-5 [30], can both decrease and increases IFN-γ [30, 29], and increases IL-10 production [29].
  • Increases CD25(high), Foxp3(+) cells [29].
  • Can increase the cytotoxic activity of peripheral CD8+ cells [38].
  • Some strains show significant capability for Th17 generation [39].


B. bifidum is considered safe but should be avoided in immunocompromised individuals, people with organ failure, and dysfunctional gut barrier, where probiotics may lead to infection.

B. bifidum cell-surface biopolymers (BPs) can interact selectively with human serum thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies (anti-TPO and anti-Tg, respectively). There is a possibility that Bifidobacteria play a role in the pathogenesis of autoimmune thyroid diseases (ATD) in those with a genetic predisposition to ATD [40].

Buy Bifidobacterium bifidum

These probiotics contain B. bifidum:

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About the Author

Biljana Novkovic

Biljana received her PhD from Hokkaido University.
Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. She is passionate about releasing the most accurate science & health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. She believes that SelfHacked has the best science that is also layperson-friendly on the web.

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