B. bifidum is a great probiotic shown to alleviate stress in students. B. bifidum also ameliorates various gastrointestinal disorders and combats infections. It is a great probiotic to supplement with in addition to eating a healthy diet. We recommend the lectin avoidance diet and have created a cookbook to make eating one of the healthiest diets very easy.
What is Bifidobacterium bifidum?
Bifidobacteria account for more than 80% of microorganisms within the intestine and Bifidobacterium bifidum is the second most prominent species found in breast-fed infants . During adulthood, the levels of Bifidobacteria decrease considerably but remain relatively stable (2-14%), decreasing again in old age .
B. bifidum is an important bacterium that inhibits human gut microbiota. This probiotic has significant health benefits, such as reducing irritable bowel syndrome, diarrhea and pathogen infections .
Health Benefits of B. bifidum
1) Combats Stress
In academically stressed undergraduate students, B. bifidum increased the proportion of healthy days per participant and decreased the percentage of participants reporting cold/flu during the intervention period .
Similarly, B. bifidum reduced self-reported stress and stress associated diarrhea/GI discomfort in undergraduate students .
2) Has Antioxidant Properties
B. bifidum exhibits antioxidant activities .
3) Beneficial for the GI Tract
B. Bifidum Improves GI Disorders
Fermented milk containing B. bifidum improves symptoms in patients with functional gastrointestinal disorders (FGID). Abdominal pain, diarrhea, and constipation significantly improved, as did acid-related dyspepsia. Psychological symptoms such as anger and hostility also improved .
Ingestion of B. bifidum significantly decreased the prevalence of gastric and lower abdominal symptoms in adults taking no medication .
B. bifidum alleviates acute gastric injury by enhancing the production of gastric mucin in rats .
B. Bifidum Beneficially Modifies Gut Microbiota
Intake of B. bifidum decreased Prevotellaceae and Prevotella and increased Ruminococcaceae and Rikenellaceae in healthy volunteers .
Intake of B. bifidum improved the microbiota of the intestinal tract of mice by increasing the number of probiotics (Lactobacilli) and by reducing unwanted bacterial populations (Enterobacter, Escherichia coli) [5, 10, 11, 12].
B. Bifidum May be Beneficial in Inflammatory Bowel Disease (IBD)
B. bifidum decreases symptoms of inflammatory bowel disease (IBD) in mice, such as thickened intestinal wall and inflammatory cell infiltration, and decreased inflammatory cytokine production .
B. Bifidum Alleviates Irritable Bowel Syndrome (IBS)
B. bifidum significantly improved the pain/discomfort, distension/bloating, urgency and digestive disorder in patients with IBS .
4) Combats H. Pylori
In a human study, B. bifidum improved rates of upper gastrointestinal symptomatic subjects and total symptoms in patients with H. pylori infection .
B. bifidum relieves damage to gastric tissues caused by H. pylori and also decreases H. pylori pathogenicity in mice .
5) May Lower Cholesterol
B. bifidum decreases total cholesterol, triglycerides, low-density lipoproteins, and very low-density lipoproteins and increases high-density lipoproteins in diabetic rats .
B. bifidum lowers cholesterol in laboratory experiments .
6) May be Beneficial in Diabetes
B. bifidum ameliorates oxidative stress, and returns the antioxidant indexes in the pancreas of diabetic rats to normal, with a reduction in lipid peroxidation and elevation in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase .
B. bifidum can stabilize blood sugar, lower cholesterol levels in serum, and improve metabolic activity in mice .
7) May Boost Immunity and Combat Infections
B. bifidum delays immunosenescence in mice by enhancing the anti-oxidation activity in thymus and spleen and improving immune function .
Galactooligosaccharides (GOSs), produced by B. bifidum reduce Salmonella enterica Typhimurium colonization and its associated pathology .
8) May be Beneficial in Allergies
Oral administration of B. bifidum significantly inhibits antigen-induced allergic nasal reactions such as sneezing and nasal obstruction in guinea pigs .
Similarly, prolonged oral administration of B. bifidum suppresses Japanese cedar pollen-induced allergic nasal symptoms in guinea pigs .
9) Good for the Skin
B. bifidum has a positive effect on the prevention and treatment of eczema in infants .
B. bifidum decreases the amount of intracellular melanin and exhibits antioxidant properties in mice, and may be beneficial as a skin-whitening ingredient in various skin hyperpigmentation disorders .
10) May be Beneficial In Lupus
Intestinal dysbiosis, characterized by a reduced Firmicutes/Bacteroidetes ratio, has been reported in systemic lupus erythematosus (SLE) patients . B. bifidum supplementation prevents CD4+ lymphocyte over-activation, and may potentially help in restoring the Treg/Th17/Th1 imbalance present in SLE .
11) May Combat Cancer
Extracts of B. bifidum inhibit the growth of colorectal cancer cells in the laboratory .
- Increases IgA, IgM, and IgG , and decreases IgE .
- Inhibits the Th1 response and reduces pro-inflammatory cytokines IL-1β, IL-6, keratinocyte-derived chemokine (KC) and the COX-2, MPO  and MCP-1  in colitis.
- Can also increase the expression of TLR-2, COX-2, and PGE2 .
- Suppresses IL-8 and NF-κB signaling pathways in H. pylori infection .
- In aging, B. bifidum stimulates the immune system, significantly increases cytokine IL-2 and IFN-γ levels but decreases proinflammatory cytokines IL-6 and TNF-α concentration .
- In allergies, B. bifidum IL-4 and IL-5 , can both decrease and increases IFN-γ [30, 29], and increases IL-10 production .
- Increases CD25(high), Foxp3(+) cells .
- Can increase the cytotoxic activity of peripheral CD8+ cells .
- Some strains show significant capability for Th17 generation .
B. bifidum is considered safe but should be avoided in immunocompromised individuals, people with organ failure, and dysfunctional gut barrier, where probiotics may lead to infection.
B. bifidum cell-surface biopolymers (BPs) can interact selectively with human serum thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies (anti-TPO and anti-Tg, respectively). There is a possibility that Bifidobacteria play a role in the pathogenesis of autoimmune thyroid diseases (ATD) in those with a genetic predisposition to ATD .
Buy Bifidobacterium bifidum
These probiotics contain B. bifidum:
- Bifidobacterium bifidum Supplements (Amazon or iHerb)
- Raw Probiotics (Amazon or iHerb)
- Probiotic-10 (Amazon or iHerb)
- Probiotic Flora (Amazon or iHerb)
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