Evidence Based

11 Moon Drop Grapes Benefits + Side Effects, Nutrition

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Moon drop grapes are a specially bred seedless variety of common grapes that have an interesting shape and sweet flavor. Because of how these grapes are grown, they are only available for a short period. But how different are they from regular grapes? Are they worth the hype?

What Are Moon Drop Grapes?

Moon drop grapes are a seedless variety of common grapes (Vitis vinifera) that are a cross between C22-121 and Beita Mouni varietals and supposedly have a distinct flavor and texture. Moon drop grapes grow over a short season and are available between August 20 and November 15, via a company called Grapery [1, 2].

What Do They Taste Like?

Moon drop grapes taste like normal grapes but are sweeter and much crunchier [1].


Like all grapes, moon drop grapes have several nutritious components. Though moon drop grapes have not been specifically studied, they contain the same compounds as common grapes, as they are the same species [3]:

Mechanisms of Action

Moon drop grapes contain fiber, which has several effects in the gut. Viscous fiber can expand in the stomach and slow down the digestion process. It can also work to bulk up fecal matter and help relieve constipation [4].

Health Benefits of Moon Drop Grapes

1) Alleviates Constipation

All grapes contain fiber, which can prevent constipation and increase the movement of material in the digestive system [4].

In a RCT with 34 people, 4 tbsp/day of a natural laxative containing raisins was more effective than prescription laxatives at producing a normal frequency and consistency of bowel movements [5].

2) May Help Strengthen Bones

Moon drop grapes have many nutrients that may be helpful for bone health, such as copper and manganese, which help in bone formation and strength. These nutrients prevent the development of conditions such as osteoporosis [6].

In a DB-RCT with 66 people, 1,000 mg of resveratrol increased bone mineral density in the spine but not hip. It also increased bone alkaline phosphatase levels, a marker of bone formation [7].

3) May Enhance Immune Function

In a study with 10 people, 5g of resveratrol increased tumor necrosis factor-α levels [8].

4) Can Lower Cholesterol Levels

300 mg of resveratrol, a compound found in moon drop grapes, decreased LDL cholesterol levels in a DB-RCT with 60 people [9].

5) Diabetes and Metabolic Syndrome

In a DB-RCT of 24 people with metabolic syndrome, 500 mg trans-resveratrol decreased weight, fat mass, BMI, waist circumference, and total insulin secretion [10].

Treatment with 250 mg/day of resveratrol improved hemoglobin A1c, total cholesterol, and systolic blood pressure but not HDL or LDL cholesterol in a RCT of 62 people [11].

However, a DB-RCT of 66 men found that resveratrol did not have any beneficial effects on metabolic syndrome. Surprisingly, 1,000 mg resveratrol actually increased total and LDL cholesterol and fructosamine levels (a marker for diabetes). Inflammatory status, sugar levels, blood pressure, and liver fat content were not improved with resveratrol treatment [12].

A DB-RCT of 192 type 2 diabetes patients also found that did not change any of the parameters measured, notably fasting glucose, insulin, hemoglobin A1c, weight, waist circumference, or blood pressure [13].

6) May Help With Non-Alcoholic Fatty Liver Disease

In a DB-RCT with 60 people, 300 mg of resveratrol improved various aspects of non-alcoholic fatty liver disease, decreasing aspartate aminotransferase, glucose, and LDL cholesterol levels [9].

7) May Be Beneficial For Heart Disease Patients

Like other grapes, moon drop grape skins contain beneficial compounds. One of these compounds, resveratrol (a polyphenol), is thought to reduce the risk of cardiovascular disease [14, 15, 16].

In a DB-RCT of 26 people with high blood pressure, red grape juice was able to reduce blood pressure for some people [17].

In studies with animal models, resveratrol had a beneficial effect on high blood pressure, clogged arteries, stroke, heart disease, irregular heartbeat, and heart failure. These effects may be due to its antioxidant and anti-inflammatory properties. However much more studies are needed to confirm this theory [14, 15, 16].

8) May Be Beneficial For Alzheimer’s Disease

Resveratrol and other phytochemicals found in grapes are thought to have a protective effect against Alzheimer’s disease [18, 19].

Grape powder containing various phytochemicals like resveratrol prevented metabolic decline in brain regions associated with the development of Alzheimer’s disease in a DB-RCT with 10 people [20].

Although 500 – 1,000 mg/day of resveratrol seemed to have some effects on the brain, it did not alter markers of Alzheimer’s disease and also increased brain volume loss in a DB-RCT of 119 people. This loss in brain volume was not associated with any cognitive or functional declines [21].

Animal and Cellular Studies

The following studies were only conducted on animal models or cell lines.

9) May Potentially Treat Cancer

According to a review study, resveratrol has potential as a cancer treatment. Consumption of grapes and grape products has also been linked to reduced cancer risk. However, resveratrol can both increase and decrease the effects of chemotherapy [22, 23, 24, 23].

10) May Potentially Prevent Age-Related Eye Diseases

Several age-related eye conditions, such as cataracts, diabetic retinopathy (vision loss), glaucoma, and macular degeneration, are thought to be related to oxidative stress and inflammation [25].

Two review studies determined that resveratrol may potentially help age-related eye diseases due to its antioxidant and anti-inflammation effects. However, human trials need to be conducted [25, 26].

11) May Potentially Treat Asthma

In two animal studies, grape extracts were beneficial for asthma due to allergies. This effect may be due to its anti-inflammatory properties [27, 28].

Side Effects

Consumption of grapes in normal amounts has very few side effects and is generally very safe. Some commonly experienced side effects include [29, 21]:

  • Abdominal cramping
  • Bloating
  • Diarrhea
  • Flatulence
  • Gas
  • Nausea
  • Weight loss

Drugs Interactions

The following listed drug interactions are not exhaustive. Please speak to your doctor if you are taking medication.

Grape juice can inhibit cyclosporine, an immunosuppressant. Common brands of cyclosporine include Neoral, Sandimmune, Gengraf, Restasis, and Restasis MultiDose [30+, 31, 32].

Resveratrol inhibits enzymes (such as CYP3A, CYP3A4) that break down or deactivate many types of drugs and therefore can increase the potency of those drugs [30+, 33, 31, 34].

Grapes and Pets

Grapes and raisins can be toxic to pets, especially dogs [35].

Limitations and Caveats

While moon drop grapes should have similar effects and properties to grapes of the same species, Vitis vinifera, there have been no studies specifically conducted on this varietal. Therefore, the results from these studies can only be theoretically applied to moon drop grapes.

Some of the effects of moon drop grapes or of the polyphenol found in grape skin, resveratrol, have only been conducted in animal models or on cell lines.

Many of the studies directly contradicted other studies. For example, while many studies touted the antioxidant and anti-inflammatory effects of resveratrol, a DB-RCT of 20 people found that 500 mg of resveratrol had no antioxidant or anti-inflammatory effects [36, 37, 38].


There is no standard dosage for grape consumption.

In the studies examining the effects of resveratrol, dosages as high as 1,000 mg/day were used but the standard dosage appears to be 500 mg/day.

Forms of Supplementation

Moon drop grapes are available as fresh fruit in grocery stores.

Resveratrol, one of the main beneficial compounds in grapes, is available as a supplement in the form of capsules or powder.

Moon Drop Grape Reviews

Most consumers said moon drop grapes are very delicious, and that the fruit could be snapped into two.

Another consumer said the tube-like shape made them attractive.

Some people said they taste like regular grapes.

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