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Luteolin is an important phytochemical found in many foods. Its health benefits range from possibly preventing cancer from protecting the brain. Read more below to find out how you can improve your health with the help of luteolin.
What is Luteolin?
Luteolin is a flavonoid found in many types of plants including fruits, vegetables, and medicinal herbs. It is known for its many health benefits. [R]
Flavonoids are common nutrients that are antioxidants and antimicrobial agents. [R]
- Luteolin is a good anti-inflammatory
- Luteolin fights against cancer cells
- Prevents cardiovascular diseases
- Enhances brain activity and memory
- May disrupts progesterone’s hormonal functions
- May increase effects of colon inflammation
- Although Luteolin is absorbed in humans (R), the body metabolizes luteolin and the bioavailability is not great (R).
- The therapeutic dosage may require an amount that is hard to get in vegetables.
Health Benefits of Luteolin
Although Luteolin is absorbed in humans (R).
1) Luteolin Fights Cancer
It inhibits the growth of new blood vessels in tumors, the metabolism of carcinogens, as well as stopping the progression of the cell cycle in cancer cells. Luteolin also induces cell death in cancer cells. [R]
Luteolin inhibited the incidence rate of tumors and decreased the size of tumors significantly. [R]
Long-term treatment did not show any apparent toxicity in rats at a dose of 30mg/kg, implying that luteolin is relatively safe as an anticancer agent. [R]
2) Luteolin Decreases Inflammation
Experiments with animals show that luteolin suppresses bacteria-induced inflammation. [R]
Luteolin suppressed pro-inflammatory marker expression and cytokine expression in LPS-activated microglia. [R]
In an experiment on rats with toxin-induced uveitis, luteolin had great success in anti-inflammatory treatment, comparable to that of prednisolone. [R]
Luteolin can also inhibit colitis (inflammation in the colon). [R]
3) Luteolin is an Antioxidant
Luteolin significantly induces genes related to antioxidant defense. [R]
4) Luteolin is a Natural Sun Protectant
5) Luteolin Improves Heart Function
Luteolin substantially increased cell life while reducing evidence of oxidative stress-induced damage in the cells. [R]
6) Luteolin Protects the Brain From Neurological Impairments
Tests on flies expressing a neurological impairment that resembles amyloidosis showed that luteolin rescued the impairment. [R]
Luteolin can go through the blood-brain-barrier (BBB), which shows anti-amnesic effects against the toxicity of amyloid in mice. [R]
Luteolin also protects against high-fat diet-induced cognitive defects in obesity of mice. [R]
Luteolin was found to have potent antiviral activity against Japanese encephalitis virus (JEV). [R]
Luteolin reduced the number of Epstein-Barr virus reactivating cells and reduced the production of the virus. It does this by repressing the activities of the promoters of the immediate-early genes Zta and Rta. [R]
In mice with hepatitis B virus (HBV), Luteolin reduced HBV DNA replication, suggesting that it may be used for anti-HBV therapy. [R]
8) Luteolin Prevents Cataracts
In rats, luteolin enhanced the antioxidant potential and lowered the oxidative damage to the lens’ of rats in selenite-induced cataracts. It also improved the membrane integrity of the lens. [R]
9) Luteolin May Be Therapeutic for Multiple Sclerosis
Multiple Sclerosis is a disease that affects the immune system – nerve damage causes pain and fatigue. Luteolin has anti-oxidant and anti-inflammatory effects which can reduce the effects of multiple sclerosis [R].
10) Luteolin Inhibits Mast Cells
Luteolin inhibits mast cells and mast cell-dependent T cell activation, factors which contribute to multiple sclerosis [R].
In this way, it can also help with histamine intolerance.
11) Luteolin Has Anti-Depressant Effects
The endoplasmic reticulum in a cell can undergo stress, which can cause cell death. In the brain, neuronal cells undergo cell death and this can cause symptoms of depression.
Luteolin significantly suppresses cell death by relieving endoplasmic reticulum stress. [R]
Negatives/Cons of Luteolin
1) Luteolin Disrupts Endocrine Activity
2) Luteolin Can Aggravate Colon Inflammation
While luteolin can help stop spontaneous colitis, it can also increase the effects of dextran sodium sulfate (DSS)-induced colitis. It blocks protective molecules in intestinal cells which prevent inflammation in the colons due to DSS. [R]
Food Sources of Luteolin
Luteolin is found commonly in a bunch of plants, specifically vegetables.
Food sources include: carrots, artichoke, peppers, celery, olive oil, peppermint, thyme, rosemary, oregano, etc. [R]
Buy Luteolin Supplements
Luteolin is not absorbed very well, so I like to take it with something that has a range of flavonoids:
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