According to preliminary research, this substance found in fruits and veggies may help with a range of chronic conditions. Still, none of its potential uses are backed up by clinical evidence. Read on to learn more about potential benefits and side effects of luteolin.
What Is Luteolin?
Luteolin is a flavonoid present in many fruits, vegetables, and medicinal herbs. Flavonoids protect plants from microbes and other environmental threats and provide us with a range of health benefits.
Did you know? Both “flavonoid” and “luteolin” have the yellow color in their names (Latin: lūteus, flavus). Luteolin is bright yellow in its crystalline form, but don’t confuse it with yellow plant pigment, lutein.
- Anti-inflammatory and antioxidant property
- Currently under investigation for many possible benefits
- Active in the nervous system of animals
- Plentiful in many healthy foods like parsley, celery, and onions
- No clinical evidence for any of its potential benefits
- May disrupt progesterone function
- May worsen colon inflammation
- Potentially beneficial doses are hard to achieve with foods
- Citrus fruits (lemon, orange, grapefruit)
- Spices (thyme, peppermint, rosemary, oregano)
- Vegetables (broccoli, cabbage, carrots, peppers)
Potential Benefits of Luteolin
Animal & Cell Research (Lacking Evidence)
No clinical evidence supports the use of luteolin for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.
Remember to speak with a doctor before taking luteolin supplements. They should never be used as a replacement for medical treatment.
1) May Protect the Brain and Nerves
- Reducing glutamate levels
- Combating brain inflammation and oxidative stress
- Supporting neuron growth in the hippocampus
- Preventing protein mutations
Studies on rats with Alzheimer’s Disease have confirmed the anti-inflammatory and brain-protecting effects of luteolin. It prevented Alzheimer’s in animals by enhancing their cognition, memory, and coordination [10, 11, 12].
- Boost glutathione and reduce oxidative brain damage
- Increase the beneficial proteins—BDNF and CREB
- Reverse cognitive impairment
- Prevent seizures and decrease their severity
- Parkinson’s disease
- Brain trauma
- Multiple sclerosis
2) Antimicrobial Properties
Luteolin prevented LPS-induced eye infection in rats by inhibiting inflammatory molecules (TNF-alpha, nitric oxide, and prostaglandin-E2). It was as effective as a corticosteroid drug, prednisolone .
In mice, luteolin inhibited the spreading of Epstein-Barr virus, preventing nose and throat cancer triggered by this virus. It also blocked the hepatitis B virus, which may cause severe liver damage [34, 35, 36].
In a cell study, luteolin showed potent activity against Japanese encephalitis virus (JEV), the leading cause of viral brain inflammation .
3) Heart Health
Cardiovascular diseases still top the list of death causes, claiming ¼ of lives in the US .
- Strengthen heart cells and enhance contractions
- Stabilize heart enzymes
- Prevent tissue damage and cell death
- Protect the cells against oxidative stress during a heart attack
4) Diabetes Complications
- Diabetic encephalopathy (brain damage)
- Diabetic neuropathy (nerve damage)
- Diabetic cystopathy (bladder dysfunction)
In test tubes, the antioxidant effects of luteolin prevented diabetic osteopathy, or bone degradation .
5) Inflammation and Allergies
It can also stabilize mast cells, which release histamine and trigger allergic reactions. Due to its anti-inflammatory properties, luteolin is being researched as a potential complementary treatment for multiple sclerosis .
6) Skin Protection
Ever heard advice to “eat your sunscreen”? Here’s how it works: when you consume them, antioxidants such as luteolin may protect your skin from the inside and prevent UV-induced damage. Still, the same might not go for taking supplements .
7) Effects on Testosterone
In one animal study, researchers have combined luteolin with an aromatase inhibitor drug to reduce its side effects in cancer treatment .
By blocking aromatase, luteolin might also work as a testosterone booster. Still, clinical trials haven’t investigated any of these effects, so they stay in the domain of theory until more research shows up .
The findings discussed below stem from animal and cell-based research only. They should guide further research, but you shouldn’t interpret them as supportive of the actual anticancer effects in humans. Luteolin supplements can not prevent or treat any kind of cancer.
In studies on mice and other lab animals, luteolin prevented the growth of:
- Prostate cancer 
- Breast cancer [61, 62, 63]
- Lung cancer 
- Stomach cancer [65, 66, 67]
- Colon cancer 
- Ovarian cancer 
- Liver cancer 
Cells studies have added pancreatic and brain cancer to the list of luteolin potential targets. According to this research, luteolin could even combat drug-resistant cancer cells and boost the effects of chemotherapy without significant side effects [71, 72, 61, 69, 73, 1].
Limitations and Caveats
Despite the promising results of various animal and cell-based studies, you shouldn’t interpret them as supportive of any health benefit until more research is done.
Luteolin Side Effects & Precautions
Keep in mind that the safety profile of luteolin is relatively unknown, given the lack of well-designed clinical studies. The list of side effects below is not a definite one, and you should consult your doctor about other potential side effects, based on your health condition and possible drug or supplement interactions.
Treatment with luteolin and other flavonoids temporarily increased irritability in 50% of children with autism spectrum disorders .
Luteolin blocks the effects of progesterone, which might be detrimental in cases of uterine and cervical cancer. The evidence around its effect on estrogen is contradicting and requires further investigation [78, 79].
Pregnant women and children should avoid luteolin supplements, unless under strict medical supervision.
Luteolin Dosage & Supplement Forms
Luteolin supplements are not well researched, and they have not been approved by the FDA for medical use. In general, regulatory bodies don’t guarantee that supplements are safe or effective. Speak with your doctor before supplementing.
Luteolin is available in different supplement forms including:
- Chewable tablets
Most products contain a mixture of luteolin and rutin, which is a flavonoid derived from quercetin. According to product labels, doses range from 100-300 mg per serving.
One supplement (NeuroProtek) contains a unique combination: luteolin + quercetin + rutin (100/70/30 mg per serving).
In addition to individual supplements and flavonoid combinations, luteolin is added to different herbal supplements for immunity and antioxidant support.
Luteolin is a flavonoid with intriguing anti-inflammatory and antioxidant properties. Food sources of luteolin include citrus fruits, leafy greens, cruciferous vegetables, and spices.
In animal and cell-based studies, luteolin was able to protect the brain and nerves, combat diabetes complications, boost cardiovascular health, and more. However, clinical trials haven’t confirmed the safety and efficacy of luteolin, and it’s still in the investigational phase.
Luteolin may worsen cervical cancer and some forms of colon inflammation. Pregnant women and children should avoid it, and everyone should consult with their doctor before supplementing.