I have solved my autoimmunity and chronic inflammation issues that held me down for most of my life, all across my site you can find the research I have compiled that has helped me become the best version of myself.
What is VIP?
VIP stimulates the heart to contract, causes vasodilation and lowers blood pressure, increases glycogen breakdown and relaxes the smooth muscle of trachea, stomach and gall bladder .
VIP increases motility, induces muscle relaxation of the GI tract (lower esophageal sphincter, stomach, gallbladder), stimulates secretion of water into pancreatic juice (such as bicarbonate) and bile, stimulates pepsinogen, and causes inhibition of stomach acid secretion (by gastrin) and inhibits absorption of water from the intestines .
VIP, Hormones, And Neurotransmitters
VIP: The Good
VIP decreases most inflammatory cytokines.
In some instances, VIP can boost the immune system. In inflammatory sites, VIP may cooperate with proinflammatory mediators, such as TNF, to induce Dendritic Cell maturation . VIP increased CCL5, which helps recruit T cells .
Protects Against Autoimmune Disease
VIP may help autoimmune/inflammatory diseases, including rheumatoid arthritis, ulcerative colitis, multiple sclerosis, Parkinson’s disease, Crohn’s disease, septic shock, uveoretinitis, and experimental models of brain inflammation .
In patients with asthma, there is a loss of VIP from the lung nerve fibers, which results in a closing of the airways (lessens bronchodilation) .
VIP has shown potent anti-inflammatory effects in mouse models of arthritis .
Patients with early arthritis who are unable to increase VIP do worse, despite receiving more intense treatment .
VIP has antimicrobial, antibacterial and antifungal properties .
VIP injected in the hippocampus exerted an anti-anxiety effect in rats .
Female mice deficient in VIP produce about half the offspring of their normal sister mice even when mated to the same males .
VIP-deficient females have a disrupted estrous cycle .
Increases Sexual Function
VIP helps induce penile erections .
VIP increases vaginal lubrication in normal women, doubling the total volume of lubrication produced .
Improves Circadian Rhythms
VIP is also involved in synchronizing the timing of SCN function with the environmental light-dark cycle .
VIP-deficient mice have less strong (i.e lower amplitude) circadian rhythms as well as our of sync clocks with the SCN and other tissue .
In the adrenals, circadian rhythms (Per1) were lost in VIP-deficient mice, while in the liver, the most dramatic impact was on the phase or timing of the rhythm .
VIP: The Bad
Most of my clients are thin and suffering from autoimmunity or its precursors.
In the research, there is a trade-off between autoimmunity and cancer.
You know: those people who don’t seem to have any chronic inflammatory issues while constantly eating unhealthy food until they’re 50 – except being overweight, of course – until one day they suddenly get cancer.
VIP is an important candidate for being the main biological difference between such people.
May Contribute to Migraines, Eczema
Blood levels of VIP are elevated in patients with Eczema, which may indicate that it can cause the disease .
May Contribute to Obesity
While VIP has some mixed effects, but on the whole, it’s thought to contribute to obesity.
VIP may explain in part why people who gain weight more easily often have lower chronic inflammation.
- VIP decreases basal metabolic rates .
- VIP stimulates insulin secretion .
- VIP decreases physical activity .
Can Contribute to Cancer
VIP combats inflammation and autoimmunity and can cause weight gain, but it also increases cancer risk.
VIP functions as a growth factor, and it has proangiogenic functions in breast and prostate cancer .
VIP increases VEGF and induces other biological mechanisms that induce tumor growth (EGFR and HER2 activation) and increase the production of cancer genes (c-fos, c-jun, and c-myc) oncogenes. There also is mounting evidence that VIP is involved in the pathogenesis of prostate cancer .
VIP stimulates prostate-specific antigen (PSA) secretion in prostate cancer .
How to Increase VIP
Besides glycine and prolonged fasts, there is insufficient information as to if and how much these methods can increase blood VIP.
If these natural methods don’t work enough, you can also try to get a script from your doc for an intranasal VIP.
Bone broth has glycine, but I prefer the supplemental form. Bone broth and chicken soup make me sleepy.
Nicotine does indeed increase gut flow pretty powerfully.
3) Vagus Nerve Stimulation
Stimulating the vagus nerve causes it to release VIP .
Long-term L-Arginine supplementation increases VIP in the rat small intestine .
6) Lemon and Limonene
Lemon and limonene increase VIP in gut tissue .
- Circadian rhythm entrainment?
- Leptin  – Leptin acts synergistically with TGF-beta to increase VIP.
- TGF beta1 
- 5-HT3R  – activates VIP neurons
- Secretin 
- cAMP/CREB 
- Baicalein  – increases VIP in certain cells infected by human cytomegalovirus . Whether it increases VIP in people is unknown.
- Ginger? Some people use ginger, but I haven’t seen any studies on ginger and VIP.
Exercise and VIP
VIP is elevated in the blood after aerobic exercise . However, anti-VIP antibodies are also increased, which results in suppression of VIP – and on the whole, it seems like exercise decreases VIP over the long term .
VIP is often low in mold illness/CIRS, which can contribute to a chronic inflammatory state.
I would recommend checking your VIP if you have chronic inflammatory or autoimmune issues. This article will explain the importance of VIP and natural ways to increase it.
Want More Targeted Ways to Combat Inflammation?
If you’re interested in natural and more targeted ways of lowering your inflammation, we at SelfHacked recommend checking out this inflammation wellness report. It gives genetic-based diet, lifestyle and supplement tips that can help reduce inflammation levels. The recommendations are personalized based on your genes.
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