Top 6 Proven Health Benefits of Hesperidin

Hesperidin found in orange peels has a wide range of benefits those including treating chronic venous insufficiency, hemorrhoids and also regulating estrogen metabolism. Listed below are the other noted health benefits of this glycoside.



Hesperidin is a flavanone glycoside (glycosylated phytopigments- plant nutrients) found  in citrus fruits, such as orange peels (R).

It is a sugar-bound form of Hesperetin, which is a flavonoid. Hesperidin must progress to the colon before it is “released.” Hesperidin promotes blood flow and weakly influences blood pressure.

It also may protect against the early stages of Streptozotocin-Induced Diabetes Mellitus (R).

Health Benefits Of Hesperidin

1) Hesperidin’s Mechanism With Diosmin


High blood pressure in the veins can cause fluid leakage, which can be returned to circulation by the lymphatic system.

During Chronic Venous Insufficiency, the lymphatic system becomes overwhelmed and this leads to edema. Following this, a White Blood Cell Inflammatory response causes further deterioration to the veins.

Hesperidin inhibits the inflammatory response and increases fluid leakage from the veins (R).

2) Hesperidin As A Treatment For Chronic Venous Insufficiency


Symptoms of Chronic Venous Insufficiency include swelling in the lower legs and varicose veins, which occurs when the veins stop working properly and cause increased blood pressure. This can lead to excessive fluid leakage and ulcers.

When taken along with Diosmin, it can be used to treat Chronic Venous Insufficiency and accelerate leg ulcer healing (R).

3) Hesperidin As A Treatment For Hemorrhoids

Hesperidin, also taken with Diosmin, can be used as a treatment for symptomatic Hemorrhoids. It may also prevent Hemorrhoids from returning (R).

4) Hesperidin May Protect Against Early Streptozotocin- Induced Diabetes Mellitus


Dietary Hesperidin had hypoglycemic and hypolipidemic effects in rats induced by STZ Type 1 Diabetes. It has been proven to increase blood flow.

It may decrease blood glucose levels and oxidative stress, and increase serum insulin concentration. The process of this occurs through altering key enzymes (G6Pase and GK) involved in glucose metabolism.

Hesperidin might inhibit oxidative damage of the pancreatic islet that produces glucagon and insulin, thus increasing insulin and decreasing glucose as a consequence.

Hesperidin normalized HDL-cholesterol levels. It also enhanced the expression of the gene encoding the LDL receptor.

Hesperidin may increase adiponectin, which can reduce lipid accumulation (R).

It can be used for blood vessel conditions, including hemorrhoids, varicose veins, and poor circulation.

Hesperidin may also work as an antidepressant in rats, most likely due to its ability to reduce hyperglycemia, behave as an antioxidant, its anti-inflammatory abilities, enhancement of neurogenesis, and control of monoamines (R).

5) Hesperidin To Treat Symptoms Arising From Estrogen Deficiency

Hesperidin may be able to treat symptoms arising from estrogen deficiency, including lowering cholesterol levels and preventing Osteoporosis (R).


A study using rats found that Hesperidin prevented bone loss in all three areas of the femur, so Hesperidin is effective on both cortical and trabecular bones.

This glycoside decreased trabecular bone resorption by decreasing the number of osteoclasts (bone cells that perform bone resorption).

Calcium levels were higher in rats that were given Hesperidin in comparison to rats that were given the placebo. The molecular mechanisms are unclear.

It regulates liver cholesterol synthesis by inhibiting HMG-CoA activity, inducing bone formation, and inhibiting bone resorption. This has been proven both in vivo and in-vitro (R).

6) Hesperidin As An Antioxidant

Hesperidin’s antioxidant abilities indicate that it may be useful in preventing cancer and as an anti-inflammatory agent (R).


There is not enough evidence currently to ensure that Hesperidin should be used as a treatment for Diabetes mellitus.

It should not be taken by patients who are taking anticoagulants, blood pressure drugs, and calcium channel drugs.

Side-effects include abdominal pain, diarrhea, contact dermatitis,and nausea (R).

While some studies show that it is useful in lowering cholesterol and triglyceride levels, other studies believe that it is not (R).

Where to Buy Hesperidin

HMC Hesperidin (AMZN).

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