Hesperidin, found in orange peels, has a wide range of benefits. They include protecting the heart and brain, reducing diabetes symptoms, and preventing cancer. Listed below are the other noted health benefits of this glycoside.
- Health Benefits Of Hesperidin
- 1) Hesperidin Works as an Antioxidant
- 2) Hesperidin Helps Prevent Cancer
- 3) Hesperidin is Anti-Inflammatory
- 4) Hesperidin Protects the Heart
- 5) Hesperidin Prevents Obesity
- 6) Hesperidin May Protect Against Diabetes
- 7) Hesperidin Protects the Brain
- 8) Hesperidin Works as an Antidepressant
- 9) Hesperidin Reduces Stress and Anxiety
- 10) Hesperidin Relieves Pain
- 11) Hesperidin Helps Treat Allergies
- 12) Hesperidin Can Treat Hemorrhoids
- 13) Hesperidin Enhances Skin Health
- 14) Hesperidin Promotes Bone Health
- 15) Hesperidin May Have Sleep-Enhancing Properties
- 16) Hesperidin May Increase Blood Flow
- 17) Hesperidin Helps Treat Chronic Venous Insufficiency
- Sources of Hesperidin
- Warnings and Side Effects
- Buy Hesperidin
Citrus fruits, mainly oranges, and tangerines contain hesperidin (R).
After consumption, hesperidin must progress to the colon before it can be readily absorbed into the body and circulate through the blood (R).
Another form of this flavonoid is hesperitin. Many studies use hesperitin instead of hesperidin. This is because drug administration is more efficient than consuming very high amounts of hesperidin.
Health Benefits Of Hesperidin
1) Hesperidin Works as an Antioxidant
Oxidants, such as hydrogen peroxide, and other chemicals can cause oxidative stress. Oxidative damage can cause disorders such as cancer and heart disease. Antioxidants can help protect against oxidative stress (R).
Both hesperidin and hesperitin can function as antioxidants. They both have radical scavenging activity. This means that they stop free radicals from damaging cells (R).
Hesperidin neutralizes reactive oxygen species. This protects DNA, proteins, and tissues from radiation, inflammation, and toxins. It also protects against oncogenes. Oncogenes are genes that can cause cells to transform into tumor cells (R).
2) Hesperidin Helps Prevent Cancer
The antioxidant activities of hesperidin can help prevent cancer. It neutralizes reactive oxygen species to protect against oncogenes. Oncogenes are genes that can cause cells to transform into tumor cells (R).
Radiation can also be toxic. It can directly damage DNA. It may also produce free radicals to alter proteins, which can cause cancer. Hesperidin significantly reduces oxidative stress induced by radiation. In rats, hesperidin injection protected them from gamma-radiation (R).
In rats, satsuma mandarin juice enhanced with hesperidin significantly reduced the incidence of colon cancer in rats (R).
In male rats suffering from colon cancer, hesperidin administration stopped cell formation. It also increased cancer cell death in the colon (R).
3) Hesperidin is Anti-Inflammatory
It also reduced inflammatory cytokine production in rats (R).
4) Hesperidin Protects the Heart
Many factors can affect heart health. Oxidative stress, high fat, high blood pressure, and high cholesterol can all contribute to an unhealthy heart. Hesperidin administration can help with all these symptoms and protect the heart.
Daily oral hesperidin administration at 100mg/kg to old rats for 90 days benefitted heart tissue. Hesperidin protected against oxidative stress and increased the antioxidant levels. It also lowered inflammation (R).
Hesperidin may increase adiponectin, a protein hormone that helps control glucose and fat metabolism. Increasing adiponectin can help reduce fat accumulation. This can help improve blood vessel conditions and improve circulation in the heart (R).
However, hesperidin does not show the same effects in humans. In men and women with high cholesterol levels, hesperidin and naringin (another citrus flavonoid) administration did not lower cholesterol levels (R).
5) Hesperidin Prevents Obesity
Glucosyl hesperidin (G-hesperidin) is a water-soluble form of hesperidin. A combination of G-hesperidin and caffeine reduces body fat in humans. It significantly reduced abdominal fat, body weight, and BMI in people with a moderately high BMI. This combination can help treat or prevent obesity (R).
6) Hesperidin May Protect Against Diabetes
Daily oral administration of hesperidin for twelve weeks mildly decreased blood glucose levels in streptozotocin-induced diabetic rats. It also stopped PKC-β and VEGF activity. This protected the rats from vision impairment (R).
7) Hesperidin Protects the Brain
D-galactose is a sugar that causes oxidative stress in the brain. It disrupts mitochondrial function and causes nerve cells to die. In rats, pretreatment with hesperidin and curcumin protected the brain. It reduced cognitive problems by preventing nerve cell death (R).
In mice models of Alzheimer’s disease, hesperidin administration reduced symptoms of the disease. 100 mg/kg per day of hesperidin reduced learning and memory problems. It also improved locomotor activity (R).
Finally, hesperidin may be able to protect the brain during strokes. 50 mg/kg of hesperidin daily for 15 days helped with brain function in male rats. It reduced inflammation. It also lowered the number of free radicals in the brain (R).
8) Hesperidin Works as an Antidepressant
In the rat model of stress-induced depression, hesperidin may be able to reduce depression symptoms. Three weeks of oral administration improved the rats’ behaviors. This may due to the regulation of the HPA axis, which is a stress response system (R).
The opioid system is also a contributing factor for major depression. Hesperidin possessed anti-depressant-like properties and positively interacts with the opioid system. It works with opioid receptors to reduce depression symptoms in mice (R).
9) Hesperidin Reduces Stress and Anxiety
Stress can cause health problems. It can increase oxidative damage in the body. It also activates the HPA axis and causes changes in the body’s homeostasis (balance). Chronic stress can cause anxiety and mood disorders (R).
10) Hesperidin Relieves Pain
11) Hesperidin Helps Treat Allergies
Immunoglobulin E (IgE) can provoke allergic reactions by release histamine and cause inflammation. In humans, administration of both hesperidin and hesperitin can suppress IgE’s effects. It inhibits histamine release and stops Th2 cytokine secretion (R).
12) Hesperidin Can Treat Hemorrhoids
Hemorrhoid patients reported less pain, swelling, and bleeding after 12 days of treatment. They also used fewer painkillers after the flavonoid administration (R).
13) Hesperidin Enhances Skin Health
Topical hesperidin treatment in mice helped with skin health. It kept the skin barrier at a balance. It also stimulated skin cell production (R).
Additionally, hesperidin can protect the skin from radiation. A compound called hesperidin methyl chalcone helped stop oxidative damage in mouse skin cells. It reduced free radicals in a mouse model of UV radiation. It also reduced inflammatory cytokine production (R).
Topical hesperetin may also be an effective skin whitening agent (R).
14) Hesperidin Promotes Bone Health
Hesperidin administration enhances osteoblast formation. Osteoblasts are cells that help with bone formation (R).
Hesperitin-7-glucuronide is the main circulating form of hesperidin. Its administration in rats helped increase bone cell formation (R).
In female mice, hesperidin supplementation prevented bone loss in all three areas of the femur. Osteoclasts are bone cells that break down bone tissue to release minerals. Hesperidin decreased the number of osteoclasts in the bones (R).
In addition to preventing bone loss, hesperidin did not have any negative effects on the uterus. However, the dose of hesperidin used in the study was much higher than the usual daily intake. It is unlikely for someone to consume that high of an amount in a normal diet (R).
Androgen deficiency can also cause bone loss. Male mice fed a diet with hesperidin had less bone loss compared to mice fed a normal diet (R).
15) Hesperidin May Have Sleep-Enhancing Properties
However, its sedative properties are only significant if it is injected into the body at a high level. Oral intake of hesperidin might not have the same effects (R).
16) Hesperidin May Increase Blood Flow
Oral administration of both hesperidin and hesperitin may increase blood flow. Daily intake of 500mg of hesperidin daily for three weeks in metabolic syndrome patients increased blood flow. This is due to the widening of their blood vessels (R).
Additionally, 150mg of a water soluble form of hesperidin can improve blood flow in women (R).
17) Hesperidin Helps Treat Chronic Venous Insufficiency
Sources of Hesperidin
- Citrus fruit hybrids
- Sundried tangerine peels
2) Various Herbs and Plants
- Boehmeria nivea (R)
- Dangshen (Codonpsis pilosula) (R)
- Japanese catnip (Schizonepeta tenuifolia) (R)
- Valeriana wallichii (R)
- Honeybush (Cyclopia subternata ) (R)
- Byrsonima crassifolia (R)
- Peppermint (Mentha × Piperita) (R)
Warnings and Side Effects
Hesperidin can slow blood clotting and increase blood flow. It may make bleeding disorders worse (R).
Many studies use very high amounts of hesperidin to get the health benefits. It would be nearly impossible to consume the required amount of hesperidin-containing food to get the same benefits as supplementation.
- 50 mg/kg hesperidin administration led to higher total protein and albumin levels in mice after irradiation (R).
- Hesperidin inhibited NF-kB activity and TNF-α, IL-1β, IL-6, and IL-10 production (R).
- Hesperitin has estrogenic effects in cell culture. Its neuroprotective effects may also depend on estrogenic signaling (R).
- Also, hesperitin can inhibit various intestinal bacteria (R).
- Hesperidin works with other orange phenols (myricetin, chlorogenic acid, and naringenin) (R).