Myelin is an important part of the nervous system and is vital for optimal cognitive function. Read more below to learn how to increase myelin in your body.
- Myelin Increases Intelligence
- Lifestyle to Increase Myelin
- Nutrition to Increase Myelin
- Hormones to Increase Myeline
- Supplements to Increase Myelin
- Pathways to Increase Myelin
- What Reduces Myelination
It improves the conduction of action potentials, which are needed to send information down the axon to other neurons (R).
The myelin sheath increases the speed of impulses in neurons. It facilitates conduction in nerves while saving space and energy (R).
Demyelination happens when the nerves lose the myelin sheath that insulates them. This can cause many neurodegenerative diseases or nerve and brain damage. Defective myelin sheaths can also cause nerve disorders (R).
It’s thought that inflammatory cytokines reduce myelination (R).
Myelin Increases Intelligence
Since myelin transmits neuronal signals, Myelin plays a critical role in determining intelligence (R).
Good myelin allows signals to travel faster, which can make everything in the brain work better.
Children’s improved cognitive performance with maturation might result from myelination (R).
Lifestyle to Increase Myelin
Sleep increases the amount of oligodendrocyte precursor cells (OPCs) in the body, which in turn increase myelin formation. Sleep is associated with higher expression of gene coding for myelination. More studies are needed to determine whether or not sleep loss impairs myelin formation and maintenance (R).
Nutrition to Increase Myelin
This is possibly due, in part, to negative impacts on neurite outgrowth and myelination (R).
2) Vitamin D
3) Vitamin C
Vitamin C, also known as ascorbate, is important as a co-factor in several enzyme reactions. Ascorbate-dependent collagen synthesis helps with myelination. Ascorbate added to rat Schwann cells and neurons promoted myelin formation (R).
The increased remyelination arose from an increase in the numbers of proliferating oligodendrocytes and oligodendrocyte precursor cells (R).
Lecithin is a component of myelin (R).
7) Vitamin B12
Cholesterol is an essential constituent of myelin. The dry mass of myelin is about 70–85% lipids.
Iron plays a key role in normal cell functions. Normal iron levels are needed for myelin formation. Iron deficiency will lead to less myelination. Therefore, iron increases myelination in the body (R).
11) Vitamin K2
Myelin membranes are particularly enriched with glycolipids, including galactosylceramide (GalCer) and its sulfated form, sulfatide (R).
Concentrations of sulfatides increase during brain development, parallel to an increase in brain myelination (R).
Decreases in myelin sulfatides content and/or changes in their molecule structure have been implicated as important factors in the disruption of myelin structure, with a subsequent attenuation of myelin efficiency as an axonal insulator (R).
Decreases in the content of myelin sulfatides with age has been implicated as a significant risk factor for behavioral deficits observed in normal aging, and age-associated neurological disorders (R).
Vitamin K has been implicated in increasing sulfatides and there is a positive correlation between sulfatides and vitamin K, which is present almost exclusively in the form of Vitamin K2 or menaquinone-4 (MK-4) in the brain (R).
In all cases, improvement was delayed from 2 to 8 months following treatment׳s onset (R).
Two multi-centric double-blind placebo-controlled trials are currently underway (R).
13) Folate/Vitamin B9
14) Pantothenic Acid/Vitamin B5
Aging of the human brain is associated with biochemical alterations and structural deterioration that impair neurotransmission (R).
Supplemental Phosphatidylserine (300-800 mg/d) is absorbed efficiently in humans, crosses the blood-brain barrier, and safely slows, halts, or reverses biochemical alterations and structural deterioration in nerve cells (R).
It supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate. It also supports rapid reactions and reflexes (R).
Hormones to Increase Myeline
The nervous system can synthesize steroids that are known as neurosteroids. They regulate the synthesis of myelin proteins and also help with its repair.
The delivery of progesterone, however, represents a challenge because of its metabolism in digestive tract and liver (R).
Recently, the intranasal route of progesterone administration has received attention for easy and efficient targeting of the brain (R).
Progesterone in the brain is derived from glands or from local synthesis by neural cells. Stimulating the natural formation of progesterone is currently explored as an alternative strategy for neuroprotection, axonal regeneration, and myelin repair (R).
Insulin-like growth factor-1 (IGF-1) has been identified as a growth factor that promotes myelination by stimulating the early events of myelination in Schwan Cells. IGF-1 stimulates two key fatty acid synthesizing enzymes via the PI3K/Akt signaling pathway (R, R).
5) Thyroid Hormones
8) Erythropoietin (EPO)
Erythropoietin (EPO) induces the expression of myelin genes in oligodendrocytes. They promote neuron repair by inducing remyelination after myelin damage. However, this only happens in erythropoietic EPO receptor (EPOR)-expressing CG4 cells (R).
Supplements to Increase Myelin
1) Gotu Kola
4) SAMe and Methylation
6) Ozone Treatment
8) Lion’s Mane
9) Forskolin/Cyclic AMP
Exercise (increases BDNF in Schwann Cells),
Pathways to Increase Myelin
1) Acetylcholine and Acetylcholinesterase Inhibitors
Increasing cholinergic stimulation helps the myelination process (R).
2) Brain-Derived Neurotrophic Factor (BDNF)
The neurotrophin brain-derived neurotrophic factor (BDNF) helps regulate myelin formation in the nervous system. An increase of BFNF levels causes an increase in the rate of myelination. This causes an increase in myelin content and thickness (R).
3) Nerve Growth Factor (NGF)
4) CB1 Cannabinoid Receptor
5) GSK3b Inhibitors
GSK3β inhibition stimulates the regeneration of myelin-forming cells and remyelination following chemically induced demyelination (R).
6) N-acetylaspartate (NAA)
8-9) PPAR delta and PPAR gamma
These are proteins that can cause big effects on gene expression, and a variety of supplements increase/decrease their function.
10) Neuregulin 1
Neuregulin 1 is important for synaptic plasticity, inhibiting the amygdala (to shut down anxiety), myelination (Schwann cell maturation, survival, and motility), heart function (cardiac growth factor) and tumor suppression.
Epidermal Growth Factor Receptor (EGFR) and ErbB3 receptor tyrosine kinase:
Epidermal growth factor receptor plays and important role in myelination and remyelination. EGFR signaling increases myelin repair and myelination (R).
Gemifribrozil, a fat lowering drug, increases the expression of myelin genes in oligodendrocytes. This may help treat demyelination (R).
The small molecule inhibitor XAV939 helps regulate Axin2 levels. Axin2 is involved in the myelination process. XAV939 promoted developmental myelination and recovery (R).
What Reduces Myelination
It’s thought that inflammatory cytokines reduce myelination (R).
Multiple sclerosis is a disease that causes demyelination.
Many studies have shown these and other cytokines to be elevated at lesion sites and in the Cerebrospinal fluid of multiple sclerosis (MS) patients, with similar findings in animal models (R).
SIRT1 inactivation increases the production of oligodendrocytes (myelin producing cells). In mice, SIRT1 inactivation will lead to oligodendrocyte production, which then increases the formation of myelin and white matter abnormalities (R).